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Q6D8D9 (DXR_ERWCT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose 5-phosphate reductoisomerase
Short name=DXP reductoisomerase
EC=1.1.1.267
Alternative name(s):
1-deoxyxylulose-5-phosphate reductoisomerase
2-C-methyl-D-erythritol 4-phosphate synthase
Gene names
Name:dxr
Ordered Locus Names:ECA1035
OrganismErwinia carotovora subsp. atroseptica (strain SCRI 1043 / ATCC BAA-672) (Pectobacterium atrosepticum) [Complete proteome] [HAMAP]
Taxonomic identifier218491 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Pectobacterium ›

Protein attributes

Sequence length398 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP-Rule MF_00183

Catalytic activity

2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH. HAMAP-Rule MF_00183

Cofactor

Divalent cation By similarity. HAMAP-Rule MF_00183

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6. HAMAP-Rule MF_00183

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00183

Sequence similarities

Belongs to the DXR family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3983981-deoxy-D-xylulose 5-phosphate reductoisomerase HAMAP-Rule MF_00183
PRO_0000163650

Regions

Nucleotide binding7 – 3630NADP By similarity

Sites

Metal binding1501Divalent metal cation By similarity
Metal binding1521Divalent metal cation By similarity
Metal binding2311Divalent metal cation By similarity
Binding site1251Substrate By similarity
Binding site1521Substrate By similarity
Binding site1861Substrate By similarity
Binding site2091Substrate By similarity
Binding site2311Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6D8D9 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 5FCC3381BE9717FB

FASTA39842,761
        10         20         30         40         50         60 
MKQLTILGST GSIGVSSLAV IKANPDKFTV RALSAGYNVK LMLEQCLTFQ PTYASMADEA 

        70         80         90        100        110        120 
SATALRQQLA EYGCKTEVLA GVQAACELAA LDGVDQVMAA IVGAAGLLPT LAAIHAGKQV 

       130        140        150        160        170        180 
LLANKESLVT CGRLFMDAVE QSDAQLLPID SEHNAIFQSL PEQIQRQLGY ASLSKHGVER 

       190        200        210        220        230        240 
IILTGSGGPF RETPVSALAD MTPDQACAHP NWSMGRKISV DSATMMNKGL EYIEARWLFN 

       250        260        270        280        290        300 
ASAEQMEVII HPQSVIHSMV RYRDGSVLAQ LGSPDMRTPI AHAMAYPERV ASGAKALDFC 

       310        320        330        340        350        360 
QIGALTFLAP DYARYPCLQL AIDACNHGQS ATTTLNAANE IAVAAFLQSQ IRFTDIAAVN 

       370        380        390 
QHVIEQLTLP EPTSVDDVLF IDSWARQVAA QTLTHYVR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX950851 Genomic DNA. Translation: CAG73946.1.
RefSeqYP_049142.1. NC_004547.2.

3D structure databases

ProteinModelPortalQ6D8D9.
SMRQ6D8D9. Positions 1-389.
ModBaseSearch...

Protein-protein interaction databases

STRING218491.ECA1035.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAG73946; CAG73946; ECA1035.
GeneID2882098.
KEGGeca:ECA1035.
PATRIC20477286. VBIPecAtr54885_1043.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0743.
HOGENOMHOG000007221.
KOK00099.
OMAAHPNWVM.
ProtClustDBPRK05447.

Enzyme and pathway databases

BioCycPATR218491:GJNB-1066-MONOMER.
UniPathwayUPA00056; UER00092.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_00183. DXP_reductoisom.
InterProIPR003821. DXP_reductoisomerase.
IPR013644. DXP_reductoisomerase_C.
IPR013512. DXP_reductoisomerase_N.
IPR026877. DXPR_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR30525. PTHR30525. 1 hit.
PfamPF08436. DXP_redisom_C. 1 hit.
PF02670. DXP_reductoisom. 1 hit.
PF13288. DXPR_C. 1 hit.
[Graphical view]
PIRSFPIRSF006205. Dxp_reductismrs. 1 hit.
SUPFAMSSF69055. SSF69055. 1 hit.
TIGRFAMsTIGR00243. Dxr. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDXR_ERWCT
AccessionPrimary (citable) accession number: Q6D8D9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: August 16, 2004
Last modified: May 1, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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