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Q6D8D0

- LPXB_PECAS

UniProt

Q6D8D0 - LPXB_PECAS

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciPATR218491:GJNB-1075-MONOMER.
UniPathwayiUPA00359; UER00481.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:ECA1044
OrganismiPectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
Taxonomic identifieri218491 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePectobacterium
ProteomesiUP000007966: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 383383Lipid-A-disaccharide synthasePRO_0000255178Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi218491.ECA1044.

Structurei

3D structure databases

ProteinModelPortaliQ6D8D0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6D8D0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSRPLTIGL VAGETSGDIL GAGLIRALKE KVPGARFVGV AGPRMQAEGC
60 70 80 90 100
EAWYEMEELA VMGIVEVLGR LPRLLKIRRD LTQRFSELQP DVFVGIDAPD
110 120 130 140 150
FNITLEGNLK QHGINTIHYV SPSVWAWRQK RVFKIGKATN LVLAFLPFEK
160 170 180 190 200
AFYDRFNVPC RFIGHTMADA MPLHPDKMTA RATLGIAPDA HCLALLPGSR
210 220 230 240 250
GAEVEMLSAD FLNTAVLLRQ HFPDLEIVVP LVNSKRREQF ERIKSSVAPD
260 270 280 290 300
LRVHLLDGQA REAMIASDAA LLASGTAALE CMLAKCPMVV GYRMKPFTFW
310 320 330 340 350
LAQRLVKTPW VSLPNLLAGR ELVTELLQTD CTPDKLAAAL LPLFADTDKM
360 370 380
AELRTTFVDL HQQIRCNADE QAAQAVLELV TPR
Length:383
Mass (Da):42,359
Last modified:August 16, 2004 - v1
Checksum:i0F65CE47E3A465A6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX950851 Genomic DNA. Translation: CAG73955.1.
RefSeqiWP_011092642.1. NC_004547.2.
YP_049151.1. NC_004547.2.

Genome annotation databases

EnsemblBacteriaiCAG73955; CAG73955; ECA1044.
GeneIDi2882740.
KEGGieca:ECA1044.
PATRICi20477304. VBIPecAtr54885_1052.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX950851 Genomic DNA. Translation: CAG73955.1 .
RefSeqi WP_011092642.1. NC_004547.2.
YP_049151.1. NC_004547.2.

3D structure databases

ProteinModelPortali Q6D8D0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 218491.ECA1044.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG73955 ; CAG73955 ; ECA1044 .
GeneIDi 2882740.
KEGGi eca:ECA1044.
PATRICi 20477304. VBIPecAtr54885_1052.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci PATR218491:GJNB-1075-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SCRI 1043 / ATCC BAA-672.

Entry informationi

Entry nameiLPXB_PECAS
AccessioniPrimary (citable) accession number: Q6D8D0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: August 16, 2004
Last modified: October 1, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3