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Q6D8D0 (LPXB_PECAS) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lipid-A-disaccharide synthase

EC=2.4.1.182
Gene names
Name:lpxB
Ordered Locus Names:ECA1044
OrganismPectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica) [Complete proteome] [HAMAP]
Taxonomic identifier218491 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePectobacterium

Protein attributes

Sequence length383 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392

Catalytic activity

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392

Sequence similarities

Belongs to the LpxB family.

Ontologies

Keywords
   Biological processLipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processlipid A biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionlipid-A-disaccharide synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 383383Lipid-A-disaccharide synthase HAMAP-Rule MF_00392
PRO_0000255178

Sequences

Sequence LengthMass (Da)Tools
Q6D8D0 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 0F65CE47E3A465A6

FASTA38342,359
        10         20         30         40         50         60 
MSSRPLTIGL VAGETSGDIL GAGLIRALKE KVPGARFVGV AGPRMQAEGC EAWYEMEELA 

        70         80         90        100        110        120 
VMGIVEVLGR LPRLLKIRRD LTQRFSELQP DVFVGIDAPD FNITLEGNLK QHGINTIHYV 

       130        140        150        160        170        180 
SPSVWAWRQK RVFKIGKATN LVLAFLPFEK AFYDRFNVPC RFIGHTMADA MPLHPDKMTA 

       190        200        210        220        230        240 
RATLGIAPDA HCLALLPGSR GAEVEMLSAD FLNTAVLLRQ HFPDLEIVVP LVNSKRREQF 

       250        260        270        280        290        300 
ERIKSSVAPD LRVHLLDGQA REAMIASDAA LLASGTAALE CMLAKCPMVV GYRMKPFTFW 

       310        320        330        340        350        360 
LAQRLVKTPW VSLPNLLAGR ELVTELLQTD CTPDKLAAAL LPLFADTDKM AELRTTFVDL 

       370        380 
HQQIRCNADE QAAQAVLELV TPR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX950851 Genomic DNA. Translation: CAG73955.1.
RefSeqYP_049151.1. NC_004547.2.

3D structure databases

ProteinModelPortalQ6D8D0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING218491.ECA1044.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAG73955; CAG73955; ECA1044.
GeneID2882740.
KEGGeca:ECA1044.
PATRIC20477304. VBIPecAtr54885_1052.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0763.
HOGENOMHOG000018003.
KOK00748.
OMAVSPITYR.
OrthoDBEOG6FBWZR.

Enzyme and pathway databases

BioCycPATR218491:GJNB-1075-MONOMER.
UniPathwayUPA00359; UER00481.

Family and domain databases

HAMAPMF_00392. LpxB.
InterProIPR003835. Glyco_trans_19.
[Graphical view]
PfamPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00215. lpxB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLPXB_PECAS
AccessionPrimary (citable) accession number: Q6D8D0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: August 16, 2004
Last modified: May 14, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways