Q6D882 (UXUA_ERWCT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannonate dehydratase
EC=4.2.1.8

Alternative name(s):
D-mannonate hydrolase

Gene names

Name:	uxuA
Ordered Locus Names:	ECA1093

Organism

Erwinia carotovora subsp. atroseptica (Pectobacterium atrosepticum) [Complete proteome] [HAMAP]

Taxonomic identifier

29471 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Pectobacterium

Protein attributes

Sequence length	398 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. HAMAP MF_00106
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00106
Sequence similarities	Belongs to the mannonate dehydratase family.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucuronate catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	mannonate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 398	398	Mannonate dehydratase HAMAP MF_00106		PRO_0000170674

Sequences

	Sequence		Length	Mass (Da)
	Q6D882 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: D914FB8FD6C25506	FASTA	398	44,976
	10 20 30 40 50 60 MEQTWRWYGP NDPVSLDDVR QAGATGVVTA LHHIPNGEIW SVEEIEKRKA ELKAKGLVWS 70 80 90 100 110 120 VVESVPVHEE IKTQTGNYQQ HIANYQQSLR NLAQCGIDTV CYNFMPVLDW TRTDLEYALP 130 140 150 160 170 180 DGSKALRFDH IAFAAFELHI LQRNGAEKDY TADEQAQAAD YYRMMSEDDI ARLTGNIIAG 190 200 210 220 230 240 LPGSEEGYTL EQFRGRLAEY DGIDHAKLRE HLAHFLREIV PVAEAAGLRL AIHPDDPPRS 250 260 270 280 290 300 ILGLPRVMST IDDMRWLKQT VDSLHNGFTF CTGSYGVRVD NDLVNMLETF ADRVHFTHLR 310 320 330 340 350 360 ATCREENPNS FHEGAHLQGD VDMVAIINAI LAEELRRQKA GDRRPIPMRP DHGHQMLDDL 370 380 390 KKKTNPGYSA IGRLKGLAEL RGVELALKCT RFTELQQG

References

[1]

"Genome sequence of the enterobacterial phytopathogen Erwinia carotovora subsp. atroseptica and characterization of virulence factors." Bell K.S., Sebaihia M., Pritchard L., Holden M.T.G., Hyman L.J., Holeva M.C., Thomson N.R., Bentley S.D., Churcher L.J.C., Mungall K., Atkin R., Bason N., Brooks K., Chillingworth T., Clark K., Doggett J., Fraser A., Hance Z. , Hauser H., Jagels K., Moule S., Norbertczak H., Ormond D., Price C., Quail M.A., Sanders M., Walker D., Whitehead S., Salmond G.P.C., Birch P.R.J., Parkhill J., Toth I.K. Proc. Natl. Acad. Sci. U.S.A. 101:11105-11110(2004) [PubMed: 15263089] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SCRI 1043 / ATCC BAA-672.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX950851 Genomic DNA. Translation: CAG74003.1.
RefSeq	YP_049199.1. NC_004547.2.
3D structure databases
ProteinModelPortal	Q6D882.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2882866.
GenomeReviews	Gene locus ECA1093 in contig BX950851_GR.
KEGG	eca:ECA1093.
NMPDR	fig|218491.3.peg.4345.
PATRIC	20477392. VBIPecAtr54885_1096.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG585927.
OMA	VHEEIKT.
ProtClustDB	PRK03906.
Enzyme and pathway databases
BioCyc	ECAR218491:ECA1093-MONOMER.
Family and domain databases
HAMAP	MF_00106. UxuA. [Tree]
InterPro	IPR004628. Man_deHydtase. IPR013022. Xyl_isomerase-like_TIM-brl. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
KO	K01686.
Pfam	PF03786. UxuA. 1 hit. [Graphical view]
PIRSF	PIRSF016049. Man_dehyd. 1 hit.
SUPFAM	SSF51658. Xyl_isomerase-like_TIM-brl. 1 hit.
TIGRFAMs	TIGR00695. UxuA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UXUA_ERWCT

Accession

Primary (citable) accession number: Q6D882

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	August 16, 2004
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program