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Protein

7-cyano-7-deazaguanine synthase

Gene

queC

Organism
Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ0).By similarity

Catalytic activityi

7-carboxy-7-carbaguanine + NH3 + ATP = 7-cyano-7-carbaguanine + ADP + phosphate + H2O.

Cofactori

Zn2+1 PublicationNote: Binds 1 zinc ion per subunit.1 Publication

Pathwayi: 7-cyano-7-deazaguanine biosynthesis

This protein is involved in the pathway 7-cyano-7-deazaguanine biosynthesis, which is part of Purine metabolism.
View all proteins of this organism that are known to be involved in the pathway 7-cyano-7-deazaguanine biosynthesis and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi188Zinc1 Publication1
Metal bindingi197Zinc1 Publication1
Metal bindingi200Zinc1 Publication1
Metal bindingi203Zinc1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 18ATPBy similarityAdd BLAST11

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Queuosine biosynthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00391.

Names & Taxonomyi

Protein namesi
Recommended name:
7-cyano-7-deazaguanine synthase (EC:6.3.4.20)
Alternative name(s):
7-cyano-7-carbaguanine synthase
PreQ(0) synthase
Queuosine biosynthesis protein QueC
Gene namesi
Name:queC
Ordered Locus Names:ECA1155
OrganismiPectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
Taxonomic identifieri218491 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesPectobacteriaceaePectobacterium
Proteomesi
  • UP000007966 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002468391 – 2317-cyano-7-deazaguanine synthaseAdd BLAST231

Proteomic databases

PRIDEiQ6D820.

Interactioni

Protein-protein interaction databases

STRINGi218491.ECA1155.

Structurei

Secondary structure

1231
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 7Combined sources5
Helixi12 – 24Combined sources13
Beta strandi26 – 38Combined sources13
Helixi40 – 53Combined sources14
Beta strandi56 – 62Combined sources7
Helixi65 – 68Combined sources4
Helixi71 – 76Combined sources6
Helixi99 – 114Combined sources16
Beta strandi117 – 120Combined sources4
Beta strandi127 – 129Combined sources3
Helixi132 – 134Combined sources3
Helixi136 – 150Combined sources15
Beta strandi155 – 157Combined sources3
Turni159 – 162Combined sources4
Helixi165 – 174Combined sources10
Helixi178 – 184Combined sources7
Turni194 – 197Combined sources4
Helixi201 – 215Combined sources15
Helixi217 – 228Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PG3X-ray2.40A1-231[»]
ProteinModelPortaliQ6D820.
SMRiQ6D820.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6D820.

Family & Domainsi

Sequence similaritiesi

Belongs to the QueC family.Curated

Phylogenomic databases

eggNOGiENOG4105FD2. Bacteria.
COG0603. LUCA.
HOGENOMiHOG000110563.
KOiK06920.
OMAiMAVSYAE.
OrthoDBiPOG091H0277.

Family and domain databases

CDDicd01995. ExsB. 1 hit.
Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_01633. QueC. 1 hit.
InterProiIPR018317. QueC.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR11587:SF3. PTHR11587:SF3. 1 hit.
PfamiPF06508. QueC. 1 hit.
[Graphical view]
PIRSFiPIRSF006293. ExsB. 1 hit.
TIGRFAMsiTIGR00364. TIGR00364. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6D820-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRAVVVFSG GQDSTTCLIQ ALQDYDDVHC ITFDYGQRHR AEIEVAQELS
60 70 80 90 100
QKLGAAAHKV LDVGLLNELA TSSLTRDSIP VPDYDANAQG IPNTFVPGRN
110 120 130 140 150
ILFLTLASIY AYQVGAEAVI TGVCETDFSG YPDCRDEFVK ALNQAIVLGI
160 170 180 190 200
ARDIRFETPL MWLNKAETWA LADYYQQLDT VRYHTLTCYN GIKGDGCGQC
210 220 230
AACHLRANGL AQYQKDAATV MASLKQKVGL R
Length:231
Mass (Da):25,363
Last modified:August 16, 2004 - v1
Checksum:iA6AEA71C503D42A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX950851 Genomic DNA. Translation: CAG74065.1.
RefSeqiWP_011092748.1. NC_004547.2.

Genome annotation databases

EnsemblBacteriaiCAG74065; CAG74065; ECA1155.
GeneIDi2885761.
KEGGieca:ECA1155.
PATRICi20477538. VBIPecAtr54885_1170.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX950851 Genomic DNA. Translation: CAG74065.1.
RefSeqiWP_011092748.1. NC_004547.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PG3X-ray2.40A1-231[»]
ProteinModelPortaliQ6D820.
SMRiQ6D820.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi218491.ECA1155.

Proteomic databases

PRIDEiQ6D820.

Protocols and materials databases

DNASUi2885761.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAG74065; CAG74065; ECA1155.
GeneIDi2885761.
KEGGieca:ECA1155.
PATRICi20477538. VBIPecAtr54885_1170.

Phylogenomic databases

eggNOGiENOG4105FD2. Bacteria.
COG0603. LUCA.
HOGENOMiHOG000110563.
KOiK06920.
OMAiMAVSYAE.
OrthoDBiPOG091H0277.

Enzyme and pathway databases

UniPathwayiUPA00391.

Miscellaneous databases

EvolutionaryTraceiQ6D820.

Family and domain databases

CDDicd01995. ExsB. 1 hit.
Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_01633. QueC. 1 hit.
InterProiIPR018317. QueC.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR11587:SF3. PTHR11587:SF3. 1 hit.
PfamiPF06508. QueC. 1 hit.
[Graphical view]
PIRSFiPIRSF006293. ExsB. 1 hit.
TIGRFAMsiTIGR00364. TIGR00364. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQUEC_PECAS
AccessioniPrimary (citable) accession number: Q6D820
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: August 16, 2004
Last modified: November 2, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.