Q6D7C2 (6PGL_ERWCT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
6-phosphogluconolactonase
Short name=6-P-gluconolactonase
EC=3.1.1.31

Gene names

Name:	pgl
Ordered Locus Names:	ECA1403

Organism

Erwinia carotovora subsp. atroseptica (Pectobacterium atrosepticum) [Complete proteome] [HAMAP]

Taxonomic identifier

29471 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Pectobacterium

Protein attributes

Sequence length	332 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate By similarity. HAMAP MF_01605
Catalytic activity	6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate. HAMAP MF_01605
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3. HAMAP MF_01605
Sequence similarities	Belongs to the cycloisomerase 2 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pentose-phosphate shunt Inferred from electronic annotation. Source: InterPro
Molecular function	6-phosphogluconolactonase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 332	332	6-phosphogluconolactonase HAMAP MF_01605		PRO_0000171135

Sequences

	Sequence		Length	Mass (Da)
	Q6D7C2 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: F2EEB874B1D0CE65	FASTA	332	36,134
	10 20 30 40 50 60 MQQVVYVASP ESQQIHVWQL GAQGNLTLLQ TVEVPGQVQP MAIAPNKRHL YVGVRPDFRV 70 80 90 100 110 120 LSYRIDEQGK LTEAGVASLP GSPTHLSTDN DGRFLFSASY SGACVSVSPI DADGIVGEPI 130 140 150 160 170 180 QQLDGLEGCH STNIDPTNTV VWAPCLKEDR IRLYDLGSVG ELSIHRQAEM TTVSGAGPRH 190 200 210 220 230 240 MAFHPNQRFA YCVNELDSSV DVYQLDAASG DVQKVQTLDA MPAGFSDTRW AADIHITPNG 250 260 270 280 290 300 NFLYISDRTA SLLSVFQISE DGSTLTLTGH QPTETQPRGF NIDHTGEFLI SAGQKSQHIE 310 320 330 VYHIDQHTGD LQPLARYAVG QGPMWVAVLA LD

References

[1]

"Genome sequence of the enterobacterial phytopathogen Erwinia carotovora subsp. atroseptica and characterization of virulence factors." Bell K.S., Sebaihia M., Pritchard L., Holden M.T.G., Hyman L.J., Holeva M.C., Thomson N.R., Bentley S.D., Churcher L.J.C., Mungall K., Atkin R., Bason N., Brooks K., Chillingworth T., Clark K., Doggett J., Fraser A., Hance Z. , Hauser H., Jagels K., Moule S., Norbertczak H., Ormond D., Price C., Quail M.A., Sanders M., Walker D., Whitehead S., Salmond G.P.C., Birch P.R.J., Parkhill J., Toth I.K. Proc. Natl. Acad. Sci. U.S.A. 101:11105-11110(2004) [PubMed: 15263089] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SCRI 1043 / ATCC BAA-672.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX950851 Genomic DNA. Translation: CAG74313.1.
RefSeq	YP_049509.1. NC_004547.2.
3D structure databases
ProteinModelPortal	Q6D7C2.
SMR	Q6D7C2. Positions 1-330.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2884854.
GenomeReviews	Gene locus ECA1403 in contig BX950851_GR.
KEGG	eca:ECA1403.
NMPDR	fig|218491.3.peg.3660.
PATRIC	20478094. VBIPecAtr54885_1439.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG741123.
OMA	FLISAGQ.
ProtClustDB	PRK11028.
Enzyme and pathway databases
BioCyc	ECAR218491:ECA1403-MONOMER.
Family and domain databases
HAMAP	MF_01605. 6P-gluconolactonase. [Tree]
InterPro	IPR022528. 6-phosphogluconolactonase_YbhE. IPR019405. Lactonase_7-beta_prop. IPR011045. N2O_reductase_N. IPR015943. WD40/YVTN_repeat-like_dom. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
KO	K07404.
Pfam	PF10282. Lactonase. 1 hit. [Graphical view]
SUPFAM	SSF50974. N2O_reductase_N. 1 hit.
ProtoNet	Search...

Entry information

Entry name

6PGL_ERWCT

Accession

Primary (citable) accession number: Q6D7C2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
Last sequence update:	August 16, 2004
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program