Q6D797 (ACDH_ERWCT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetaldehyde dehydrogenase
EC=1.2.1.10

Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]

Gene names

Name:	mhpF
Synonyms:	nahO
Ordered Locus Names:	ECA1428

Organism

Erwinia carotovora subsp. atroseptica (strain SCRI 1043 / ATCC BAA-672) (Pectobacterium atrosepticum) [Complete proteome] [HAMAP]

Taxonomic identifier

218491 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Pectobacterium › Erwinia carotovora subsp. atroseptica

Protein attributes

Sequence length	296 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657
Catalytic activity	Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657
Pathway	Aromatic compound metabolism; 3-phenylpropanoate degradation. HAMAP-Rule MF_01657
Subunit structure	Interacts with MhpE By similarity.
Sequence similarities	Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
Biological process	Aromatic hydrocarbons catabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	3-phenylpropionate catabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	NAD binding Inferred from electronic annotation. Source: HAMAP acetaldehyde dehydrogenase (acetylating) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 296	296	Acetaldehyde dehydrogenase HAMAP-Rule MF_01657		PRO_0000387659
Regions
	Nucleotide binding	15 – 18	4	NAD By similarity
	Nucleotide binding	164 – 172	9	NAD By similarity
Sites
	Active site	132	1	Acyl-thioester intermediate By similarity
	Binding site	274	1	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6D797 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 791192875713316D	FASTA	296	31,975
	10 20 30 40 50 60 MTNLNKKVRV GIIGSGNIGT DLLIKTMRSE SLTCTIFAGR NFNSAGMKRA NELGVHISDR 70 80 90 100 110 120 GIQAILDDPS ICDVVFDATS AQAHIEHWRE LEPLDKTVID MTPAKVGGFC IPAINAEEIL 130 140 150 160 170 180 ASGNRNINMV TCGGQSSIPI ANAISSVHPE FEYIEVASSI ASRSAGPATR ANLDEYIDTT 190 200 210 220 230 240 EKALKQFTGA QRTKAILILN PAVPPIDMQT TIYAKIDRPN IAAIDAAVRE MVERLKRYVP 250 260 270 280 290 GYQLVLPPTL DGNRVVTTVK VMGNGDYLPQ YAGNLDIINC AAIAVTEMIS SLRYGK

References

[1]

"Genome sequence of the enterobacterial phytopathogen Erwinia carotovora subsp. atroseptica and characterization of virulence factors." Bell K.S., Sebaihia M., Pritchard L., Holden M.T.G., Hyman L.J., Holeva M.C., Thomson N.R., Bentley S.D., Churcher L.J.C., Mungall K., Atkin R., Bason N., Brooks K., Chillingworth T., Clark K., Doggett J., Fraser A., Hance Z. , Hauser H., Jagels K., Moule S., Norbertczak H., Ormond D., Price C., Quail M.A., Sanders M., Walker D., Whitehead S., Salmond G.P.C., Birch P.R.J., Parkhill J., Toth I.K. Proc. Natl. Acad. Sci. U.S.A. 101:11105-11110(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SCRI 1043 / ATCC BAA-672.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX950851 Genomic DNA. Translation: CAG74338.1.
RefSeq	YP_049534.1. NC_004547.2.
3D structure databases
ProteinModelPortal	Q6D797.
ModBase	Search...
Protein-protein interaction databases
STRING	218491.ECA1428.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAG74338; CAG74338; ECA1428.
GeneID	2884611.
KEGG	eca:ECA1428.
PATRIC	20478144. VBIPecAtr54885_1464.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG4569.
HOGENOM	HOG000052149.
KO	K04073.
OMA	LKQQVQF.
ProtClustDB	PRK08300.
Enzyme and pathway databases
BioCyc	PATR218491:GJNB-1468-MONOMER.
UniPathway	UPA00714.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
HAMAP	MF_01657. Ac_ald_DH_ac.
InterPro	IPR003361. Acetaldehyde_dehydrogenase. IPR015426. Acetylaldehyde_DH_C. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view]
PANTHER	PTHR21123. PTHR21123. 1 hit.
Pfam	PF09290. AcetDehyd-dimer. 1 hit. PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
PIRSF	PIRSF015689. Actaldh_dh_actl. 1 hit.
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACDH_ERWCT

Accession

Primary (citable) accession number: Q6D797

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 3, 2009
Last sequence update:	August 16, 2004
Last modified:	May 1, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program