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Q6D797 (ACDH_PECAS) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase

EC=1.2.1.10
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]
Gene names
Name:mhpF
Synonyms:nahO
Ordered Locus Names:ECA1428
OrganismPectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica) [Complete proteome] [HAMAP]
Taxonomic identifier218491 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePectobacterium

Protein attributes

Sequence length296 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657

Pathway

Aromatic compound metabolism; 3-phenylpropanoate degradation. HAMAP-Rule MF_01657

Subunit structure

Interacts with MhpE By similarity. HAMAP-Rule MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process3-phenylpropionate catabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

acetaldehyde dehydrogenase (acetylating) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 296296Acetaldehyde dehydrogenase HAMAP-Rule MF_01657
PRO_0000387659

Regions

Nucleotide binding15 – 184NAD By similarity
Nucleotide binding164 – 1729NAD By similarity

Sites

Active site1321Acyl-thioester intermediate By similarity
Binding site2741NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6D797 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 791192875713316D

FASTA29631,975
        10         20         30         40         50         60 
MTNLNKKVRV GIIGSGNIGT DLLIKTMRSE SLTCTIFAGR NFNSAGMKRA NELGVHISDR 

        70         80         90        100        110        120 
GIQAILDDPS ICDVVFDATS AQAHIEHWRE LEPLDKTVID MTPAKVGGFC IPAINAEEIL 

       130        140        150        160        170        180 
ASGNRNINMV TCGGQSSIPI ANAISSVHPE FEYIEVASSI ASRSAGPATR ANLDEYIDTT 

       190        200        210        220        230        240 
EKALKQFTGA QRTKAILILN PAVPPIDMQT TIYAKIDRPN IAAIDAAVRE MVERLKRYVP 

       250        260        270        280        290 
GYQLVLPPTL DGNRVVTTVK VMGNGDYLPQ YAGNLDIINC AAIAVTEMIS SLRYGK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX950851 Genomic DNA. Translation: CAG74338.1.
RefSeqYP_049534.1. NC_004547.2.

3D structure databases

ProteinModelPortalQ6D797.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING218491.ECA1428.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAG74338; CAG74338; ECA1428.
GeneID2884611.
KEGGeca:ECA1428.
PATRIC20478144. VBIPecAtr54885_1464.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG4569.
HOGENOMHOG000052149.
KOK04073.
OMAHQGNVNM.
OrthoDBEOG6H1PXH.

Enzyme and pathway databases

BioCycPATR218491:GJNB-1468-MONOMER.
UniPathwayUPA00714.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01657. Ac_ald_DH_ac.
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACDH_PECAS
AccessionPrimary (citable) accession number: Q6D797
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: August 16, 2004
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways