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Q6D797

- ACDH_PECAS

UniProt

Q6D797 - ACDH_PECAS

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Protein

Acetaldehyde dehydrogenase

Gene
mhpF, nahO, ECA1428
Organism
Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei132 – 1321Acyl-thioester intermediate By similarity
Binding sitei274 – 2741NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 184NAD By similarity
Nucleotide bindingi164 – 1729NAD By similarity

GO - Molecular functioni

  1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
  2. NAD binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 3-phenylpropionate catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciPATR218491:GJNB-1468-MONOMER.
UniPathwayiUPA00714.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase (EC:1.2.1.10)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]
Gene namesi
Name:mhpF
Synonyms:nahO
Ordered Locus Names:ECA1428
OrganismiPectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
Taxonomic identifieri218491 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePectobacterium
ProteomesiUP000007966: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 296296Acetaldehyde dehydrogenaseUniRule annotationPRO_0000387659Add
BLAST

Interactioni

Subunit structurei

Interacts with MhpE By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi218491.ECA1428.

Structurei

3D structure databases

ProteinModelPortaliQ6D797.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OMAiHQGNVNM.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6D797-1 [UniParc]FASTAAdd to Basket

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MTNLNKKVRV GIIGSGNIGT DLLIKTMRSE SLTCTIFAGR NFNSAGMKRA    50
NELGVHISDR GIQAILDDPS ICDVVFDATS AQAHIEHWRE LEPLDKTVID 100
MTPAKVGGFC IPAINAEEIL ASGNRNINMV TCGGQSSIPI ANAISSVHPE 150
FEYIEVASSI ASRSAGPATR ANLDEYIDTT EKALKQFTGA QRTKAILILN 200
PAVPPIDMQT TIYAKIDRPN IAAIDAAVRE MVERLKRYVP GYQLVLPPTL 250
DGNRVVTTVK VMGNGDYLPQ YAGNLDIINC AAIAVTEMIS SLRYGK 296
Length:296
Mass (Da):31,975
Last modified:August 16, 2004 - v1
Checksum:i791192875713316D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX950851 Genomic DNA. Translation: CAG74338.1.
RefSeqiWP_011093012.1. NC_004547.2.
YP_049534.1. NC_004547.2.

Genome annotation databases

EnsemblBacteriaiCAG74338; CAG74338; ECA1428.
GeneIDi2884611.
KEGGieca:ECA1428.
PATRICi20478144. VBIPecAtr54885_1464.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX950851 Genomic DNA. Translation: CAG74338.1 .
RefSeqi WP_011093012.1. NC_004547.2.
YP_049534.1. NC_004547.2.

3D structure databases

ProteinModelPortali Q6D797.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 218491.ECA1428.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG74338 ; CAG74338 ; ECA1428 .
GeneIDi 2884611.
KEGGi eca:ECA1428.
PATRICi 20478144. VBIPecAtr54885_1464.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K04073.
OMAi HQGNVNM.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

UniPathwayi UPA00714 .
BioCyci PATR218491:GJNB-1468-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SCRI 1043 / ATCC BAA-672.

Entry informationi

Entry nameiACDH_PECAS
AccessioniPrimary (citable) accession number: Q6D797
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: August 16, 2004
Last modified: September 3, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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