Reviewed, UniProtKB/Swiss-Prot Q6D6E0 (BETB_ERWCT)

Names and origin

Protein names

Recommended name:
    Betaine aldehyde dehydrogenase
      Short name=BADH
    EC=1.2.1.8

Gene names

Name:	betB
Ordered Locus Names:	ECA1745

Organism

Erwinia carotovora subsp. atroseptica (Pectobacterium atrosepticum) [Complete proteome] [HAMAP]

Taxonomic identifier

29471 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Pectobacterium

Protein attributes

Sequence length	490 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP MF_00804
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP MF_00804
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	betaine-aldehyde dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 490	490	Betaine aldehyde dehydrogenase HAMAP MF_00804		PRO_0000056544
Regions
	Nucleotide binding	229 – 234	6	NAD By similarity
Sites
	Active site	252	1	By similarity
	Active site	286	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6D6E0-1 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: DFDF502DFC05D95E	FASTA	490	52,854
	10 20 30 40 50 60 MSRYGLQQLY INGAYVDSTG NDTFDAVNPA NGDIIACIQS ATAADVDRAV SAATAGQKVW 70 80 90 100 110 120 AAMTAMERSR ILRRAVDILR ERNDELALLE THDTGKPLSE TRTVDIVTGA DVLEYYAGLI 130 140 150 160 170 180 PMLEGQQIPL RDTSFVYTRR EPLGVVAGIG AWNYPIQIAL WKSAPALAAG NAMIFKPSEV 190 200 210 220 230 240 TSLTALKLAE IYTEAGLPAG VFNVLTGTGK SVGQALTTHP GIAKVSFTGG IASGKTVMAN 250 260 270 280 290 300 AAGSTLKDVT MELGGKSPLI IFDDADLDKA ADIAMMANFF SSGQVCTNGT RVFVPKALQA 310 320 330 340 350 360 QFEEKILACV QRIRAGDPTD ESVNFGPLVS FPHRESVLRY IESGKREGAR VLVGGEPMTD 370 380 390 400 410 420 GDYAQGAYVA PTVFTDCRDD MKIVRKEIFG PVMSILTYQD EDEVIRRAND SEYGLAAGIV 430 440 450 460 470 480 TRDLNRAHRV IHQLEAGICW INTWGESPAE MPVGGYKHSG VGRENGVTTL EHYTQIKSIQ 490 VELGEFRSVF

References

[1]

"Genome sequence of the enterobacterial phytopathogen Erwinia carotovora subsp. atroseptica and characterization of virulence factors." Bell K.S., Sebaihia M., Pritchard L., Holden M.T.G., Hyman L.J., Holeva M.C., Thomson N.R., Bentley S.D., Churcher L.J.C., Mungall K., Atkin R., Bason N., Brooks K., Chillingworth T., Clark K., Doggett J., Fraser A., Hance Z. , Hauser H., Jagels K., Moule S., Norbertczak H., Ormond D., Price C., Quail M.A., Sanders M., Walker D., Whitehead S., Salmond G.P.C., Birch P.R.J., Parkhill J., Toth I.K. Proc. Natl. Acad. Sci. U.S.A. 101:11105-11110(2004) [PubMed: 15263089] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SCRI 1043 / ATCC BAA-672.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX950851 Genomic DNA. Translation: CAG74650.1.
RefSeq	YP_049845.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2882566.
GenomeReviews	Gene locus ECA1745 in contig BX950851_GR.
KEGG	eca:ECA1745.
NMPDR	fig|218491.3.peg.215.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6D6E0.
OMA	Q6D6E0. AHRTIHR.
Enzyme and pathway databases
BioCyc	ECAR218491:ECA1745-MON.
BRENDA	1.2.1.8. 281579.
Family and domain databases
HAMAP	MF_00804. [Tree]
InterPro	IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. IPR011264. Betaine_Ald_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01804. BADH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETB_ERWCT

Accession

Primary (citable) accession number: Q6D6E0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	August 16, 2004
Last modified:	June 16, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)