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Q6D6D9 (BETA_PECAS) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Oxygen-dependent choline dehydrogenase

Short name=CDH
Short name=CHD
EC=1.1.99.1
Alternative name(s):
Betaine aldehyde dehydrogenase
Short name=BADH
EC=1.2.1.8
Gene names
Name:betA
Ordered Locus Names:ECA1746
OrganismPectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica) [Complete proteome] [HAMAP]
Taxonomic identifier218491 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePectobacterium

Protein attributes

Sequence length559 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate By similarity. HAMAP-Rule MF_00750

Catalytic activity

Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP-Rule MF_00750

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP-Rule MF_00750

Cofactor

FAD By similarity. HAMAP-Rule MF_00750

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP-Rule MF_00750

Sequence similarities

Belongs to the GMC oxidoreductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 559559Oxygen-dependent choline dehydrogenase HAMAP-Rule MF_00750
PRO_0000258924

Regions

Nucleotide binding4 – 3330FAD By similarity

Sites

Active site4711 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6D6D9 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: E7BD0CA73F8D314A

FASTA55962,102
        10         20         30         40         50         60 
MEYDYIIIGA GSAGNVLAAR LTEESDVSVL LLEAGGPDYR LDFRTQMPAA LAFPLQGKRY 

        70         80         90        100        110        120 
NWAYETDPEP HMNDRRMECG RGKGLGGSSL INGMCYIRGN AMDFDHWATM SGLEDWSYLD 

       130        140        150        160        170        180 
CLPYFRKAET RDVGANDYHG ASGPVSVTTP KMGNNELFHA MVEAGVQAGY PRTDDLNGYQ 

       190        200        210        220        230        240 
QEGFGPMDRT VTPKGRRAST ARGYLDQAKS RKNLTIVTHA LTDRILFDGK RAVGVAYFKG 

       250        260        270        280        290        300 
ESAQTAKARR EVLLCAGAIA SPQILQRSGV GPKDLLQRLD ISVVHDLPGV GENLQDHLEM 

       310        320        330        340        350        360 
YLQYACKEPV SLYPALQWFN QPKIGAEWLF NGTGIGASNQ FEAGGFIRSR DEFTWPNIQY 

       370        380        390        400        410        420 
HFLPVAINYN GSNAVKEHGF QAHVGSMRSL SRGRVQVRSK DAREHPSILF NYMSTEQDWQ 

       430        440        450        460        470        480 
EFRDAIRITR EIMAQPALDK YRGREISPGL AVQTDEELDE FIRTHAETAF HPSCSCKMGE 

       490        500        510        520        530        540 
DDMSVVDGQG CVHGMEGLRV VDASIMPQII TGNLNATTIM IAEKIADRIR RRQPLPRSKA 

       550 
RYYVAGSTPV RKAPLKPAS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX950851 Genomic DNA. Translation: CAG74651.1.
RefSeqYP_049846.1. NC_004547.2.

3D structure databases

ProteinModelPortalQ6D6D9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING218491.ECA1746.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAG74651; CAG74651; ECA1746.
GeneID2882565.
KEGGeca:ECA1746.
PATRIC20478768. VBIPecAtr54885_1773.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2303.
HOGENOMHOG000139600.
KOK00108.
OMAYLQYACT.
OrthoDBEOG67HJQP.

Enzyme and pathway databases

BioCycPATR218491:GJNB-1784-MONOMER.
UniPathwayUPA00529; UER00385.

Family and domain databases

HAMAPMF_00750. Choline_dehydrogen.
InterProIPR011533. Choline_dehydrogenase.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsTIGR01810. betA. 1 hit.
PROSITEPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETA_PECAS
AccessionPrimary (citable) accession number: Q6D6D9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: August 16, 2004
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways