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Q6D674 (NAGZ_PECAS) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-hexosaminidase

EC=3.2.1.52
Alternative name(s):
Beta-N-acetylhexosaminidase
N-acetyl-beta-glucosaminidase
Gene names
Name:nagZ
Ordered Locus Names:ECA1813
OrganismPectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica) [Complete proteome] [HAMAP]
Taxonomic identifier218491 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePectobacterium

Protein attributes

Sequence length342 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides By similarity. HAMAP-Rule MF_00364

Catalytic activity

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. HAMAP-Rule MF_00364

Pathway

Cell wall biogenesis; peptidoglycan recycling. HAMAP-Rule MF_00364

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00364.

Sequence similarities

Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 342342Beta-hexosaminidase HAMAP-Rule MF_00364
PRO_0000234912

Regions

Region163 – 1642Substrate binding By similarity

Sites

Active site1761Proton donor/acceptor By similarity
Active site2481Nucleophile By similarity
Binding site621Substrate By similarity
Binding site701Substrate By similarity
Binding site1331Substrate By similarity
Site1741Important for catalytic activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6D674 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: C0AA9F4511D32A45

FASTA34237,736
        10         20         30         40         50         60 
MGPVMLDVAS YELDAEDREV LEHPLVGGVI LFTRNFHDVA QLRELVRQIR AASHERLVVS 

        70         80         90        100        110        120 
VDQEGGRVQR FRDGFTRLPA AQAFAALNSV SEAQRLAEEG GWLMAAEMIA MDIDISFAPV 

       130        140        150        160        170        180 
LDIGHQSAAI GERSFHEQPE MALAVAQSFI RGMHSAGMKV TGKHFPGHGA VSADSHKETP 

       190        200        210        220        230        240 
RDPRPLAEIR AHDMLIFKAL IQSQQLDAIM PAHVIYTEAD PHPASGSSYW LKTVLREELG 

       250        260        270        280        290        300 
FDGIIFSDDL SMEGAAVMGS YPERAQAALQ AGCDMILVCN HREGAISVLD NLSPVKAEQL 

       310        320        330        340 
TRLYHQGSFS RRELLDSPRW KLANQALTSL SERWQAHKNG EK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX950851 Genomic DNA. Translation: CAG74717.1.
RefSeqYP_049911.1. NC_004547.2.

3D structure databases

ProteinModelPortalQ6D674.
SMRQ6D674. Positions 1-334.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING218491.ECA1813.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAG74717; CAG74717; ECA1813.
GeneID2884609.
KEGGeca:ECA1813.
PATRIC20478908. VBIPecAtr54885_1842.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1472.
HOGENOMHOG000248526.
KOK01207.
OMAMGSYPER.
OrthoDBEOG6BCT06.
ProtClustDBPRK05337.

Enzyme and pathway databases

BioCycPATR218491:GJNB-1852-MONOMER.
UniPathwayUPA00544.

Family and domain databases

Gene3D3.20.20.300. 1 hit.
HAMAPMF_00364. NagZ.
InterProIPR022956. Beta_hexosaminidase_bac.
IPR019800. Glyco_hydro_3_AS.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamPF00933. Glyco_hydro_3. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
PROSITEPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNAGZ_PECAS
AccessionPrimary (citable) accession number: Q6D674
Entry history
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: August 16, 2004
Last modified: April 16, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries