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Protein

N-acetyl-D-glucosamine kinase

Gene

nagK

Organism
Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.UniRule annotation

Catalytic activityi

ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi157 – 1571ZincUniRule annotation
Metal bindingi177 – 1771ZincUniRule annotation
Metal bindingi179 – 1791ZincUniRule annotation
Metal bindingi184 – 1841ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi4 – 118ATPUniRule annotation
Nucleotide bindingi133 – 1408ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. N-acetylglucosamine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. N-acetylglucosamine metabolic process Source: UniProtKB-HAMAP
  2. peptidoglycan turnover Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciPATR218491:GJNB-1864-MONOMER.
UniPathwayiUPA00544.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyl-D-glucosamine kinaseUniRule annotation (EC:2.7.1.59UniRule annotation)
Alternative name(s):
GlcNAc kinaseUniRule annotation
Gene namesi
Name:nagKUniRule annotation
Ordered Locus Names:ECA1826
OrganismiPectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
Taxonomic identifieri218491 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePectobacterium
ProteomesiUP000007966 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 304304N-acetyl-D-glucosamine kinasePRO_0000270105Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi218491.ECA1826.

Structurei

3D structure databases

ProteinModelPortaliQ6D662.
SMRiQ6D662. Positions 1-303.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ROK (NagC/XylR) family. NagK subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1940.
HOGENOMiHOG000150087.
KOiK00884.
OMAiAYEPEVI.
OrthoDBiEOG61P6P0.

Family and domain databases

HAMAPiMF_01271. GlcNAc_kinase.
InterProiIPR023505. N-acetyl-D-glucosamine_kinase.
IPR000600. ROK.
[Graphical view]
PfamiPF00480. ROK. 1 hit.
[Graphical view]
PROSITEiPS01125. ROK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6D662-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYYGFDMGGT KIELGVFDAE LNKVWQKRVP TPRNNYDDLL AMLIDLVHEA
60 70 80 90 100
DAQVGVQGSV GIGVPGIQTG DEGALFTANL PATMGKPLRI DLSQRLQRDV
110 120 130 140 150
RISNDANCFV LSEAWDAEFR SYPVVLGLIL GTGLGGGLVI NGRPVDGRNG
160 170 180 190 200
IAGEFGHLRL PSDALDIIGV DIPRVKCGCG QFGCIENYIS GRGFEWLYEH
210 220 230 240 250
LYGEALPAVT IIRHYRGGEE KALEFVDRFM DLLAACLGNL LTLFDPHLLV
260 270 280 290 300
LGGGLSNFDE IYQILPTRLP SRLLPIAKLP RIEKARHGDA GGVRGAALLH

LMDN
Length:304
Mass (Da):33,095
Last modified:August 16, 2004 - v1
Checksum:i833343DC6B5A3356
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX950851 Genomic DNA. Translation: CAG74729.1.
RefSeqiYP_049923.1. NC_004547.2.

Genome annotation databases

EnsemblBacteriaiCAG74729; CAG74729; ECA1826.
KEGGieca:ECA1826.
PATRICi20478934. VBIPecAtr54885_1855.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX950851 Genomic DNA. Translation: CAG74729.1.
RefSeqiYP_049923.1. NC_004547.2.

3D structure databases

ProteinModelPortaliQ6D662.
SMRiQ6D662. Positions 1-303.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi218491.ECA1826.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAG74729; CAG74729; ECA1826.
KEGGieca:ECA1826.
PATRICi20478934. VBIPecAtr54885_1855.

Phylogenomic databases

eggNOGiCOG1940.
HOGENOMiHOG000150087.
KOiK00884.
OMAiAYEPEVI.
OrthoDBiEOG61P6P0.

Enzyme and pathway databases

UniPathwayiUPA00544.
BioCyciPATR218491:GJNB-1864-MONOMER.

Family and domain databases

HAMAPiMF_01271. GlcNAc_kinase.
InterProiIPR023505. N-acetyl-D-glucosamine_kinase.
IPR000600. ROK.
[Graphical view]
PfamiPF00480. ROK. 1 hit.
[Graphical view]
PROSITEiPS01125. ROK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SCRI 1043 / ATCC BAA-672.

Entry informationi

Entry nameiNAGK_PECAS
AccessioniPrimary (citable) accession number: Q6D662
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: August 16, 2004
Last modified: April 29, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.