Q6D606 (CCMA_ERWCT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c biogenesis ATP-binding export protein CcmA
EC=3.6.3.41

Alternative name(s):
Heme exporter protein A

Gene names

Name:	ccmA
Ordered Locus Names:	ECA1882

Organism

Erwinia carotovora subsp. atroseptica (Pectobacterium atrosepticum) [Complete proteome] [HAMAP]

Taxonomic identifier

29471 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Pectobacterium

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system By similarity. HAMAP MF_01707
Catalytic activity	ATP + H2O + heme(In) = ADP + phosphate + heme(Out). HAMAP MF_01707
Subunit structure	The complex is composed of two ATP-binding proteins (CcmA) and two transmembrane proteins (CcmB) By similarity.
Subcellular location	Cell inner membrane; Peripheral membrane protein By similarity HAMAP MF_01707.
Sequence similarities	Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. [View classification] Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Cytochrome c-type biogenesis Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cytochrome complex assembly Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW heme-transporting ATPase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 206	206	Cytochrome c biogenesis ATP-binding export protein CcmA HAMAP MF_01707		PRO_0000092180
Regions
	Domain	2 – 206	205	ABC transporter
	Nucleotide binding	34 – 41	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6D606 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 9A8CB2551A192395	FASTA	206	22,827
	10 20 30 40 50 60 MLEARDVVCI RDEHVLFSAL SFTASSGEMV QIAGANGVGK TSLLRMLSGL ATPESGDVCW 70 80 90 100 110 120 QGQRINRIRE HFNQQLLWLG HQPGIKSVLT GEENLRFFYP QQHQDAHWQA LAAVGLAGYE 130 140 150 160 170 180 DVPVARLSAG QQRRVALARL WLTDVPLWIL DEPLTALDVA GVEMLTQRME HHIAHGGIII 190 200 LTTHQPLRPF AQSIRCIQLT PSEGTP

References

[1]

"Genome sequence of the enterobacterial phytopathogen Erwinia carotovora subsp. atroseptica and characterization of virulence factors." Bell K.S., Sebaihia M., Pritchard L., Holden M.T.G., Hyman L.J., Holeva M.C., Thomson N.R., Bentley S.D., Churcher L.J.C., Mungall K., Atkin R., Bason N., Brooks K., Chillingworth T., Clark K., Doggett J., Fraser A., Hance Z. , Hauser H., Jagels K., Moule S., Norbertczak H., Ormond D., Price C., Quail M.A., Sanders M., Walker D., Whitehead S., Salmond G.P.C., Birch P.R.J., Parkhill J., Toth I.K. Proc. Natl. Acad. Sci. U.S.A. 101:11105-11110(2004) [PubMed: 15263089] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SCRI 1043 / ATCC BAA-672.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX950851 Genomic DNA. Translation: CAG74785.1.
RefSeq	YP_049979.1. NC_004547.2.
3D structure databases
ProteinModelPortal	Q6D606.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2882166.
GenomeReviews	Gene locus ECA1882 in contig BX950851_GR.
KEGG	eca:ECA1882.
NMPDR	fig|218491.3.peg.40.
PATRIC	20479048. VBIPecAtr54885_1912.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG758042.
OMA	PFNAIDK.
ProtClustDB	PRK13538.
Enzyme and pathway databases
BioCyc	ECAR218491:ECA1882-MONOMER.
Family and domain databases
HAMAP	MF_01707. ABC_ATPase_CcmA. [Tree]
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR005895. ABC_transptr_haem_export_CcmA. IPR003593. ATPase_AAA+_core. [Graphical view]
KO	K02193.
Pfam	PF00005. ABC_tran. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01189. CcmA. 1 hit.
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. PS51243. CCMA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CCMA_ERWCT

Accession

Primary (citable) accession number: Q6D606

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	August 16, 2004
Last modified:	January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program