Reviewed, UniProtKB/Swiss-Prot Q6D4W5 (ARAA_ERWCT)

Names and origin

Protein names

Recommended name:
    L-arabinose isomerase
    EC=5.3.1.4

Gene names

Name:	araA
Ordered Locus Names:	ECA2275

Organism

Erwinia carotovora subsp. atroseptica (Pectobacterium atrosepticum) [Complete proteome] [HAMAP]

Taxonomic identifier

29471 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Pectobacterium

Protein attributes

Sequence length	501 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the conversion of L-arabinose to L-ribulose By similarity. HAMAP MF_00519
Catalytic activity	L-arabinose = L-ribulose. HAMAP MF_00519
Cofactor	Binds 1 manganese ion per subunit By similarity. HAMAP MF_00519
Pathway	Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3. HAMAP MF_00519
Subunit structure	Homohexamer By similarity. HAMAP MF_00519
Sequence similarities	Belongs to the arabinose isomerase family.

Ontologies

Keywords
Biological process	Arabinose catabolism Carbohydrate metabolism
Ligand	Manganese Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arabinose catabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	L-arabinose isomerase activity Inferred from electronic annotation. Source: HAMAP manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 501	501	L-arabinose isomerase HAMAP MF_00519		PRO_0000198388
Sites
	Metal binding	306	1	Manganese By similarity
	Metal binding	333	1	Manganese By similarity
	Metal binding	350	1	Manganese By similarity
	Metal binding	450	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6D4W5-1 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: BBF869A9523B722E	FASTA	501	55,893
	10 20 30 40 50 60 MDHFKQLEVW FVIGSQHLYG PETLRQVKEN AEKVVAGLNQ QANLPVKLVL KPLVKTPDEI 70 80 90 100 110 120 LALCRDANYQ DNCIGLLTWL HTFSPAKMWI GGLSVLSKPL LQFHTQFNAE VPWDTMDMDF 130 140 150 160 170 180 MNLNQTAHGG REFGFIGARM RQAHQVVVGH WQDKNAHVRI GKWMRVAAAI QESKQLKVAR 190 200 210 220 230 240 FGDNMREVAV TEGDKVGAQI QFGYSVSAWG LGDLTAVVDA VSKGDIDALI EEYETSYQLT 250 260 270 280 290 300 DAVKLNGANR QNLLDAAQIE LGMKRFLEQG GYHAFTTDFE NLYGLKQLPG LAVQRLMQQG 310 320 330 340 350 360 YGFGGEGDWK TAALLRIMKV MAGGLSGGTS FMEDYTYNFQ NGNDLVVGSH MLEVCPTIAK 370 380 390 400 410 420 EQKPILDAQH LGIGGKADPA RLIFSTPAGP SLNASVIDMG DRFRMLVNLV DTIEQPRPLP 430 440 450 460 470 480 KLPVARAIWK AQPSLEVAAE AWILAGGAHH TVFSQALDLD HMRLYAEMQN IELLVIDNET 490 500 RLHEFKDALR WNEVYYKLCS R

References

[1]

"Genome sequence of the enterobacterial phytopathogen Erwinia carotovora subsp. atroseptica and characterization of virulence factors." Bell K.S., Sebaihia M., Pritchard L., Holden M.T.G., Hyman L.J., Holeva M.C., Thomson N.R., Bentley S.D., Churcher L.J.C., Mungall K., Atkin R., Bason N., Brooks K., Chillingworth T., Clark K., Doggett J., Fraser A., Hance Z. , Hauser H., Jagels K., Moule S., Norbertczak H., Ormond D., Price C., Quail M.A., Sanders M., Walker D., Whitehead S., Salmond G.P.C., Birch P.R.J., Parkhill J., Toth I.K. Proc. Natl. Acad. Sci. U.S.A. 101:11105-11110(2004) [PubMed: 15263089] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SCRI 1043 / ATCC BAA-672.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX950851 Genomic DNA. Translation: CAG75178.1.
RefSeq	YP_050370.1.
3D structure databases
SMR	Q6D4W5. Positions 1-496.
ModBase	Search...
Genome annotation databases
GeneID	2884164.
GenomeReviews	Gene locus ECA2275 in contig BX950851_GR.
KEGG	eca:ECA2275.
NMPDR	fig|218491.3.peg.1790.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG297198.
OMA	EVCPTIA.
Enzyme and pathway databases
BioCyc	ECAR218491:ECA2275-MONOMER.
BRENDA	5.3.1.4. 281579.
Family and domain databases
HAMAP	MF_00519. Arabinose_Isome. [Tree]
InterPro	IPR003762. Lara_isomerase. [Graphical view]
Pfam	PF02610. Arabinose_Isome. 1 hit. [Graphical view]
PIRSF	PIRSF001478. L-ara_isomerase. 1 hit.
ProDom	PD018364. Lara_isomerase. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

ARAA_ERWCT

Accession

Primary (citable) accession number: Q6D4W5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	August 16, 2004
Last modified:	January 19, 2010
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)