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Protein

Cardiolipin synthase A

Gene

clsA

Organism
Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.UniRule annotation

Catalytic activityi

2 Phosphatidylglycerol = diphosphatidylglycerol + glycerol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei224UniRule annotation1
Active sitei226UniRule annotation1
Active sitei231UniRule annotation1
Active sitei404UniRule annotation1
Active sitei406UniRule annotation1
Active sitei411UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciPATR218491:G1G3T-2363-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cardiolipin synthase AUniRule annotation (EC:2.7.8.-UniRule annotation)
Short name:
CL synthaseUniRule annotation
Gene namesi
Name:clsAUniRule annotation
Synonyms:cls
Ordered Locus Names:ECA2318
OrganismiPectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
Taxonomic identifieri218491 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesPectobacteriaceaePectobacterium
Proteomesi
  • UP000007966 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalUniRule annotationAdd BLAST21
Transmembranei38 – 58HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000774981 – 486Cardiolipin synthase AAdd BLAST486

Interactioni

Protein-protein interaction databases

STRINGi218491.ECA2318

Structurei

3D structure databases

ProteinModelPortaliQ6D4S2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini219 – 246PLD phosphodiesterase 1UniRule annotationAdd BLAST28
Domaini399 – 426PLD phosphodiesterase 2UniRule annotationAdd BLAST28

Sequence similaritiesi

Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily.UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CQX Bacteria
COG1502 LUCA
HOGENOMiHOG000077403
KOiK06131
OMAiGGHNVGD
OrthoDBiPOG091H04OR

Family and domain databases

HAMAPiMF_00190 Cardiolipin_synth_ClsA, 1 hit
InterProiView protein in InterPro
IPR022924 Cardiolipin_synthase
IPR030840 CL_synthase_A
IPR027379 CLS_N
IPR025202 PLD-like_dom
IPR001736 PLipase_D/transphosphatidylase
PfamiView protein in Pfam
PF13091 PLDc_2, 2 hits
PF13396 PLDc_N, 1 hit
SMARTiView protein in SMART
SM00155 PLDc, 2 hits
TIGRFAMsiTIGR04265 bac_cardiolipin, 1 hit
PROSITEiView protein in PROSITE
PS50035 PLD, 2 hits

Sequencei

Sequence statusi: Complete.

Q6D4S2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTFYTVISW LLVFSYWLLI AGVTLRILMK RRAVPSAMAW LLVIYILPLV
60 70 80 90 100
GIVAYLSFGE LHLGKRRAER ASKMWPSTAK WLRELKEYRR IFATENSEVA
110 120 130 140 150
SALFQLCERR QGVGGVKGNQ LQLMTTFDDT IKALLRDIEL ARNNIEMVFY
160 170 180 190 200
IWQPGGLVEQ VTSSLISAAR RGVHCRILLD SAGSVQFFRQ HHPELMRTAG
210 220 230 240 250
IEVVEALKVN LFRAFLRRMD LRQHRKIILI DSRIAYTGSM NMVDPRLFKQ
260 270 280 290 300
DAGVGQWIDL MARIEGPVAT TLGIIYCCDW EMETGKRLLP PPPDVNVMPF
310 320 330 340 350
EQESGHTIQV IASGPGYPEE MIHQALLTSV YSARKQLIMT TPYFVPSDDL
360 370 380 390 400
LHAICTAAQR GVDVSIIVPH KNDSVLVGWA SRAFFTELLA AGVKIYQFKD
410 420 430 440 450
GLLHTKSVLV DGQLSLVGTV NLDMRSLWLN FEITLVIDDA GFGSDLACVQ
460 470 480
EDYIARSRLL NATQWQNRPY WQRIVERLFY FFSPLL
Length:486
Mass (Da):55,249
Last modified:August 16, 2004 - v1
Checksum:i17FB51D018A0BD8D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX950851 Genomic DNA Translation: CAG75221.1
RefSeqiWP_011093875.1, NC_004547.2

Genome annotation databases

EnsemblBacteriaiCAG75221; CAG75221; ECA2318
KEGGieca:ECA2318
PATRICifig|218491.5.peg.2344

Similar proteinsi

Entry informationi

Entry nameiCLSA_PECAS
AccessioniPrimary (citable) accession number: Q6D4S2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 16, 2004
Last modified: June 20, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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