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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate.
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate phosphoribosyltransferase (pncB)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase, Transferase
Biological processPyridine nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferase (EC:6.3.4.21)
Short name:
NAPRTase
Gene namesi
Name:pncB
Ordered Locus Names:ECA2540
OrganismiPectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
Taxonomic identifieri218491 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesPectobacteriaceaePectobacterium
Proteomesi
  • UP000007966 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002058311 – 401Nicotinate phosphoribosyltransferaseAdd BLAST401

Interactioni

Protein-protein interaction databases

STRINGi218491.ECA2540.

Structurei

3D structure databases

ProteinModelPortaliQ6D454.
SMRiQ6D454.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.

Phylogenomic databases

eggNOGiENOG4107RH7. Bacteria.
COG1488. LUCA.
HOGENOMiHOG000284928.
KOiK00763.
OMAiKLTMQCA.
OrthoDBiPOG091H0197.

Family and domain databases

HAMAPiMF_00570. NAPRTase. 1 hit.
InterProiView protein in InterPro
IPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR036068. Nicotinate_pribotase_like_C.
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiView protein in Pfam
PF04095. NAPRTase. 1 hit.
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6D454-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLHTSPILH SLLDTDAYKL HMQQAVYHHY YDVDVAAEFR CRGDELLGVY
60 70 80 90 100
ADEIAHQVDL MRFLSLSDDE FTYLSSLPFF QQDYLNWLRN FRFNPQQVSI
110 120 130 140 150
KNNAGKLDIR ITGPWREVIL WEVPLLAVIS EVVHRHRSPN VTTEQAVAQL
160 170 180 190 200
STSLESFRQN SMNVDLSQFK LMDFGTRRRF SGDIQQTIVT ALQADFPYLI
210 220 230 240 250
GTSNYDLARR LGITPVGTQA HEWFQAHQQI SPTLANSQRA ALQMWLREYP
260 270 280 290 300
THLGIALTDC ITMDAFLRDF DLPFAEAYQG LRHDSGDPVD WGEKAIAHYQ
310 320 330 340 350
RLNIDPMSKT LVFSDNLNLD KALVLYRHFC QRVNLVFGMG TRLTCDIPGV
360 370 380 390 400
KPLNIVIKLV ECNGKPVAKL SDSPGKTICQ DQNFVCELRK AFDLPRVKKA

S
Length:401
Mass (Da):45,867
Last modified:August 16, 2004 - v1
Checksum:iB9241D05BE30246F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX950851 Genomic DNA. Translation: CAG75439.1.
RefSeqiWP_011094085.1. NC_004547.2.

Genome annotation databases

EnsemblBacteriaiCAG75439; CAG75439; ECA2540.
KEGGieca:ECA2540.
PATRICifig|218491.5.peg.2572.

Similar proteinsi

Entry informationi

Entry nameiPNCB_PECAS
AccessioniPrimary (citable) accession number: Q6D454
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: August 16, 2004
Last modified: October 25, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families