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Q6D411

- HISX_PECAS

UniProt

Q6D411 - HISX_PECAS

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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei138 – 1381NADUniRule annotation
Binding sitei196 – 1961NADUniRule annotation
Binding sitei219 – 2191NADUniRule annotation
Binding sitei245 – 2451SubstrateUniRule annotation
Metal bindingi267 – 2671ZincUniRule annotation
Binding sitei267 – 2671SubstrateUniRule annotation
Metal bindingi270 – 2701ZincUniRule annotation
Binding sitei270 – 2701SubstrateUniRule annotation
Active sitei334 – 3341Proton acceptorUniRule annotation
Active sitei335 – 3351Proton acceptorUniRule annotation
Binding sitei335 – 3351SubstrateUniRule annotation
Metal bindingi368 – 3681ZincUniRule annotation
Binding sitei368 – 3681SubstrateUniRule annotation
Binding sitei422 – 4221SubstrateUniRule annotation
Metal bindingi427 – 4271ZincUniRule annotation
Binding sitei427 – 4271SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciPATR218491:GJNB-2626-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:ECA2583
OrganismiPectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
Taxonomic identifieri218491 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePectobacterium
ProteomesiUP000007966: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 442442Histidinol dehydrogenasePRO_0000135769Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi218491.ECA2583.

Structurei

3D structure databases

ProteinModelPortaliQ6D411.
SMRiQ6D411. Positions 10-442.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6D411-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADNTNSTGS FSTLVDWQRC SVEEQRQLLT RPAISASDRI TAVVSDILTN
60 70 80 90 100
VKSRGDGALR DYSAQFDKVQ VDAIRITDAE IAAASARLGD EVKQAMAIAV
110 120 130 140 150
RNIETFHNAQ KLPIVDIETQ PGVRCQQITR PIATVGLYIP GGSAPLPSTV
160 170 180 190 200
LMLGTPSRIA GCRRVVLCSP PPIADEILYA AQLCGIKEVF QLGGAQAIAA
210 220 230 240 250
MAFGTDSVPK VDKIFGPGNA YVTEAKRQVS QQLDGAAIDM PAGPSEVLVI
260 270 280 290 300
ADSGATPAFV ASDLLSQAEH GPDSQVILLT PDAVMAKAVA DAVEEQLTQL
310 320 330 340 350
SRADIARQAL ASSRVIVARD LAQCIEISNQ YGPEHLIIQT RDAESLVDSI
360 370 380 390 400
TSAGSVFLGD WSPESAGDYA SGTNHVLPTY GYTSTYSSLG LADFQKRMTV
410 420 430 440
QQLTPQGLLQ LAPTIEILAQ AEQLTAHKNA VTLRVAALKE QA
Length:442
Mass (Da):46,850
Last modified:August 16, 2004 - v1
Checksum:i1BE05D0BA8FAC677
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX950851 Genomic DNA. Translation: CAG75482.1.
RefSeqiWP_011094128.1. NC_004547.2.
YP_050674.1. NC_004547.2.

Genome annotation databases

EnsemblBacteriaiCAG75482; CAG75482; ECA2583.
GeneIDi2882559.
KEGGieca:ECA2583.
PATRICi20480467. VBIPecAtr54885_2617.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX950851 Genomic DNA. Translation: CAG75482.1 .
RefSeqi WP_011094128.1. NC_004547.2.
YP_050674.1. NC_004547.2.

3D structure databases

ProteinModelPortali Q6D411.
SMRi Q6D411. Positions 10-442.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 218491.ECA2583.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG75482 ; CAG75482 ; ECA2583 .
GeneIDi 2882559.
KEGGi eca:ECA2583.
PATRICi 20480467. VBIPecAtr54885_2617.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci PATR218491:GJNB-2626-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SCRI 1043 / ATCC BAA-672.

Entry informationi

Entry nameiHISX_PECAS
AccessioniPrimary (citable) accession number: Q6D411
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: August 16, 2004
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3