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Q6D411

- HISX_PECAS

UniProt

Q6D411 - HISX_PECAS

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Protein
Histidinol dehydrogenase
Gene
hisD, ECA2583
Organism
Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei138 – 1381NAD By similarity
Binding sitei196 – 1961NAD By similarity
Binding sitei219 – 2191NAD By similarity
Binding sitei245 – 2451Substrate By similarity
Metal bindingi267 – 2671Zinc By similarity
Binding sitei267 – 2671Substrate By similarity
Metal bindingi270 – 2701Zinc By similarity
Binding sitei270 – 2701Substrate By similarity
Active sitei334 – 3341Proton acceptor By similarity
Active sitei335 – 3351Proton acceptor By similarity
Binding sitei335 – 3351Substrate By similarity
Metal bindingi368 – 3681Zinc By similarity
Binding sitei368 – 3681Substrate By similarity
Binding sitei422 – 4221Substrate By similarity
Metal bindingi427 – 4271Zinc By similarity
Binding sitei427 – 4271Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciPATR218491:GJNB-2626-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:ECA2583
OrganismiPectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
Taxonomic identifieri218491 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePectobacterium
ProteomesiUP000007966: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 442442Histidinol dehydrogenaseUniRule annotation
PRO_0000135769Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi218491.ECA2583.

Structurei

3D structure databases

ProteinModelPortaliQ6D411.
SMRiQ6D411. Positions 10-442.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6D411-1 [UniParc]FASTAAdd to Basket

« Hide

MADNTNSTGS FSTLVDWQRC SVEEQRQLLT RPAISASDRI TAVVSDILTN    50
VKSRGDGALR DYSAQFDKVQ VDAIRITDAE IAAASARLGD EVKQAMAIAV 100
RNIETFHNAQ KLPIVDIETQ PGVRCQQITR PIATVGLYIP GGSAPLPSTV 150
LMLGTPSRIA GCRRVVLCSP PPIADEILYA AQLCGIKEVF QLGGAQAIAA 200
MAFGTDSVPK VDKIFGPGNA YVTEAKRQVS QQLDGAAIDM PAGPSEVLVI 250
ADSGATPAFV ASDLLSQAEH GPDSQVILLT PDAVMAKAVA DAVEEQLTQL 300
SRADIARQAL ASSRVIVARD LAQCIEISNQ YGPEHLIIQT RDAESLVDSI 350
TSAGSVFLGD WSPESAGDYA SGTNHVLPTY GYTSTYSSLG LADFQKRMTV 400
QQLTPQGLLQ LAPTIEILAQ AEQLTAHKNA VTLRVAALKE QA 442
Length:442
Mass (Da):46,850
Last modified:August 16, 2004 - v1
Checksum:i1BE05D0BA8FAC677
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX950851 Genomic DNA. Translation: CAG75482.1.
RefSeqiYP_050674.1. NC_004547.2.

Genome annotation databases

EnsemblBacteriaiCAG75482; CAG75482; ECA2583.
GeneIDi2882559.
KEGGieca:ECA2583.
PATRICi20480467. VBIPecAtr54885_2617.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX950851 Genomic DNA. Translation: CAG75482.1 .
RefSeqi YP_050674.1. NC_004547.2.

3D structure databases

ProteinModelPortali Q6D411.
SMRi Q6D411. Positions 10-442.
ModBasei Search...

Protein-protein interaction databases

STRINGi 218491.ECA2583.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG75482 ; CAG75482 ; ECA2583 .
GeneIDi 2882559.
KEGGi eca:ECA2583.
PATRICi 20480467. VBIPecAtr54885_2617.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci PATR218491:GJNB-2626-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SCRI 1043 / ATCC BAA-672.

Entry informationi

Entry nameiHISX_PECAS
AccessioniPrimary (citable) accession number: Q6D411
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: August 16, 2004
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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