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Q6D400 (SERC_ERWCT) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoserine aminotransferase
EC=2.6.1.52
Alternative name(s):
Phosphohydroxythreonine aminotransferase
Short name=PSAT
Gene names
Name:serC
Ordered Locus Names:ECA2594
OrganismErwinia carotovora subsp. atroseptica (Pectobacterium atrosepticum) [Complete proteome] [HAMAP]
Taxonomic identifier29471 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Pectobacterium

Protein attributes

Sequence length361 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine By similarity. HAMAP MF_00160

Catalytic activity

O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate. HAMAP MF_00160

4-phosphonooxy-L-threonine + 2-oxoglutarate = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate. HAMAP MF_00160

Cofactor

Binds 1 pyridoxal phosphate per subunit By similarity. HAMAP MF_00160

Pathway

Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3. HAMAP MF_00160

Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 3/5. HAMAP MF_00160

Subunit structure

Homodimer By similarity. HAMAP MF_00160

Subcellular location

Cytoplasm By similarity HAMAP MF_00160.

Sequence similarities

Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 361361Phosphoserine aminotransferase HAMAP MF_00160
PRO_0000150171

Regions

Region76 – 772Pyridoxal phosphate binding By similarity
Region238 – 2392Pyridoxal phosphate binding By similarity

Sites

Binding site421L-glutamate By similarity
Binding site1021Pyridoxal phosphate By similarity
Binding site1531Pyridoxal phosphate By similarity
Binding site1731Pyridoxal phosphate By similarity
Binding site1961Pyridoxal phosphate By similarity

Amino acid modifications

Modified residue1971N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6D400 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 3EAC940F805DAD12

FASTA36140,277
        10         20         30         40         50         60 
MTQIFNFSAG PAMLPVEVLR RAEQELCNWN GLGTSVMEIS HRSKEFMQVA AESEQDLRDL 

        70         80         90        100        110        120 
LKIPSNYKVL FCHGGARAQF AAVPLNLLGE RSTADYIDGG YWAHSAINEA EKYCTPNVID 

       130        140        150        160        170        180 
VKTRIDDLRG IKPMREWKLS DDAAFVHYCP NETIDGIAIE EEPDFGDKIV VADYSSSILS 

       190        200        210        220        230        240 
RRIDVSRYGV IYAGAQKNIG PAGLTLVIVR EDLLGKARRE LPSILDYQVL ADNDSMFNTP 

       250        260        270        280        290        300 
PTFAWYLSGM VFKWLKEHGG LAEMEKRNQE KADLLYSAID GNDFYRNDVA LANRSRMNVP 

       310        320        330        340        350        360 
FLLADSALDK VFLEESVAAG LHALKGHRVV GGMRASIYNA MPLEGVKALT EFMADFARRH 


G

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX950851 Genomic DNA. Translation: CAG75493.1.
RefSeqYP_050685.1. NC_004547.2.

3D structure databases

ProteinModelPortalQ6D400.
SMRQ6D400. Positions 3-361.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2884404.
GenomeReviewsGene locus ECA2594 in contig BX950851_GR.
KEGGeca:ECA2594.
NMPDRfig|218491.3.peg.1713.
PATRIC20480489. VBIPecAtr54885_2628.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG289982.
OMAYEVLFLQ.
ProtClustDBPRK05355.

Enzyme and pathway databases

BioCycECAR218491:ECA2594-MONOMER.

Family and domain databases

HAMAPMF_00160. SerC_aminotrans_5.
[Tree]
InterProIPR000192. Aminotrans_V/Cys_dSase.
IPR020578. Aminotrans_V_PyrdxlP_BS.
IPR022278. Pser_aminoTfrase.
IPR003248. Pser_aminoTfrase_subgr.
IPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
Gene3DG3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KOK00831.
PANTHERPTHR21152:SF1. PTHR21152:SF1. 1 hit.
PfamPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFPIRSF000525. SerC. 1 hit.
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMsTIGR01364. SerC_1. 1 hit.
PROSITEPS00595. AA_TRANSFER_CLASS_5. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSERC_ERWCT
AccessionPrimary (citable) accession number: Q6D400
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2004
Last modified: January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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