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Q6D3N3 (GCH1_PECAS) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase 1

EC=3.5.4.16
Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I
Gene names
Name:folE
Ordered Locus Names:ECA2711
OrganismPectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica) [Complete proteome] [HAMAP]
Taxonomic identifier218491 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePectobacterium

Protein attributes

Sequence length220 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223

Subunit structure

Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity.

Sequence similarities

Belongs to the GTP cyclohydrolase I family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 220220GTP cyclohydrolase 1 HAMAP-Rule MF_00223
PRO_1000043692

Sites

Metal binding1091Zinc By similarity
Metal binding1121Zinc By similarity
Metal binding1801Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6D3N3 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 19FF789E247444C2

FASTA22024,570
        10         20         30         40         50         60 
MSSLSKEAVM VHEALLARGL ETPLRGALLD RDTRKQRIAE HMTEIMNLLS LDLGDDSLAE 

        70         80         90        100        110        120 
TPTRIAKMYV DEIFSGLDYA NFPKITIIEN KMKVDEMVTV RDITLTSTCE HHFVMIDGKA 

       130        140        150        160        170        180 
TVAYIPKDGV IGLSKLNRIV QFFSQRPQVQ ERLTQQILVA LQTLLGTNNV AVSIDAVHYC 

       190        200        210        220 
VKARGIRDAT SATTTTSLGG LFKSSQNTRQ EFLRAVRHHN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX950851 Genomic DNA. Translation: CAG75611.1.
RefSeqYP_050802.1. NC_004547.2.

3D structure databases

ProteinModelPortalQ6D3N3.
SMRQ6D3N3. Positions 3-220.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING218491.ECA2711.

Proteomic databases

PRIDEQ6D3N3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAG75611; CAG75611; ECA2711.
GeneID2885248.
KEGGeca:ECA2711.
PATRIC20480721. VBIPecAtr54885_2744.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0302.
HOGENOMHOG000221222.
KOK01495.
OMAVQFFSQR.
OrthoDBEOG6XHC8G.
ProtClustDBPRK09347.

Enzyme and pathway databases

BioCycPATR218491:GJNB-2754-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_00223. FolE.
InterProIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERPTHR11109. PTHR11109. 1 hit.
PfamPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsTIGR00063. folE. 1 hit.
PROSITEPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH1_PECAS
AccessionPrimary (citable) accession number: Q6D3N3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 16, 2004
Last modified: April 16, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways