Reviewed, UniProtKB/Swiss-Prot Q6D3B4 (CDD_ERWCT)

Names and origin

Protein names

Recommended name:
    Cytidine deaminase
    EC=3.5.4.5
Alternative name(s):
    Cytidine aminohydrolase
      Short name=CDA

Gene names

Name:	cdd
Ordered Locus Names:	ECA2830

Organism

Erwinia carotovora subsp. atroseptica (Pectobacterium atrosepticum) [Complete proteome] [HAMAP]

Taxonomic identifier

29471 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Pectobacterium

Protein attributes

Sequence length	296 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity.
Catalytic activity	Cytidine + H2O = uridine + NH3. HAMAP MF_01558
Cofactor	Binds 1 zinc ion By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the cytidine and deoxycytidylate deaminase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cytidine metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	cytidine deaminase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 296	296	Cytidine deaminase HAMAP MF_01558		PRO_0000171648
Regions
	Region	89 – 91	3	Substrate binding By similarity
Sites
	Active site	104	1	Proton donor By similarity
	Metal binding	102	1	Zinc; catalytic By similarity
	Metal binding	129	1	Zinc; catalytic By similarity
	Metal binding	132	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6D3B4-1 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: EB0F81D33A5007E1	FASTA	296	31,972
	10 20 30 40 50 60 MHTRFENAFQ QLSASLQDAL GPLIDKPDFA AMLTADEVNA VCEASQLDVD ALAFALLPLA 70 80 90 100 110 120 AACAQASISN FQVGAIAQGL SGNFYFGANM EFTAVQLQQT VHAEQSAVSH AWLRNERGLR 130 140 150 160 170 180 AVTVNYTPCG HCRQFMNELR NAASLRIQLP GRQPAVLSHY LPDAFGPVDL QIDTLLMDDI 190 200 210 220 230 240 NHGATLQNVN ALTRQALDAA NRSHAPYSKA ISGIALETAS GNIYTGRYAE NAAFNPSLPP 250 260 270 280 290 LQAALNLMNL AGEDPSTIKY AAVVERRNAV VSHWAISQIM LAELGCTDVE HHFIEE

References

[1]

"Genome sequence of the enterobacterial phytopathogen Erwinia carotovora subsp. atroseptica and characterization of virulence factors." Bell K.S., Sebaihia M., Pritchard L., Holden M.T.G., Hyman L.J., Holeva M.C., Thomson N.R., Bentley S.D., Churcher L.J.C., Mungall K., Atkin R., Bason N., Brooks K., Chillingworth T., Clark K., Doggett J., Fraser A., Hance Z. , Hauser H., Jagels K., Moule S., Norbertczak H., Ormond D., Price C., Quail M.A., Sanders M., Walker D., Whitehead S., Salmond G.P.C., Birch P.R.J., Parkhill J., Toth I.K. Proc. Natl. Acad. Sci. U.S.A. 101:11105-11110(2004) [PubMed: 15263089] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SCRI 1043 / ATCC BAA-672.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX950851 Genomic DNA. Translation: CAG75730.1.
RefSeq	YP_050921.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2881831.
GenomeReviews	Gene locus ECA2830 in contig BX950851_GR.
KEGG	eca:ECA2830.
NMPDR	fig|218491.3.peg.897.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6D3B4.
OMA	FSPCGHC.
Enzyme and pathway databases
BioCyc	ECAR218491:ECA2830-MON.
BRENDA	3.5.4.5. 281579.
Family and domain databases
HAMAP	MF_01558. [Tree]
InterPro	IPR016192. APOBEC/CMP_deaminase_Zn-bd. IPR002125. CMP_dCMP_Zn_bd. IPR013171. Cyd/dCyd_deaminase_Zn_bd. IPR006263. Cyt_deam_dimer. [Graphical view]
Pfam	PF00383. dCMP_cyt_deam_1. 1 hit. PF08211. dCMP_cyt_deam_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01355. cyt_deam_dimer. 1 hit.
PROSITE	PS00903. CYT_DCMP_DEAMINASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDD_ERWCT

Accession

Primary (citable) accession number: Q6D3B4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	August 16, 2004
Last modified:	November 3, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)