Reviewed, UniProtKB/Swiss-Prot Q6D364 (PGSA_ERWCT)

Names and origin

Protein names

Recommended name:
    CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
    EC=2.7.8.5
Alternative name(s):
    Phosphatidylglycerophosphate synthase
      Short name=PGP synthase

Gene names

Name:	pgsA
Ordered Locus Names:	ECA2880

Organism

Erwinia carotovora subsp. atroseptica (Pectobacterium atrosepticum) [Complete proteome] [HAMAP]

Taxonomic identifier

29471 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Pectobacterium

Protein attributes

Sequence length	182 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This protein catalyzes the committed step to the synthesis of the acidic phospholipids By similarity.
Catalytic activity	CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate. HAMAP MF_01437
Pathway	Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2. HAMAP MF_01437
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 182	181	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase HAMAP MF_01437		PRO_0000239123
Regions
	Topological domain	2 – 12	11	Cytoplasmic Potential
	Transmembrane	13 – 37	25	Potential
	Topological domain	38 – 60	23	Periplasmic Potential
	Transmembrane	61 – 81	21	Potential
	Topological domain	82 – 86	5	Cytoplasmic Potential
	Transmembrane	87 – 107	21	Potential
	Topological domain	108 – 145	38	Periplasmic Potential
	Transmembrane	146 – 168	23	Potential
	Topological domain	169 – 181	13	Cytoplasmic Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6D364-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: C576718E2A51E9ED	FASTA	182	20,767
	10 20 30 40 50 60 MQFNIPTLLT LFRVALIPFF VLAFYLPFVW APLLCALIFV FAAVTDWFDG FLARRWKQTT 70 80 90 100 110 120 RFGAFLDPVA DKVMVAVALV LVAEYYHSWW ITLPAATMIA REIIISALRE WMAEIGKRSS 130 140 150 160 170 180 VAVSWIGKVK TTAQMMALFA LLWRPERIVE GIGVAALYIA AVLTFWSMFQ YLNAARHDLL EP

References

[1]

"Genome sequence of the enterobacterial phytopathogen Erwinia carotovora subsp. atroseptica and characterization of virulence factors." Bell K.S., Sebaihia M., Pritchard L., Holden M.T.G., Hyman L.J., Holeva M.C., Thomson N.R., Bentley S.D., Churcher L.J.C., Mungall K., Atkin R., Bason N., Brooks K., Chillingworth T., Clark K., Doggett J., Fraser A., Hance Z. , Hauser H., Jagels K., Moule S., Norbertczak H., Ormond D., Price C., Quail M.A., Sanders M., Walker D., Whitehead S., Salmond G.P.C., Birch P.R.J., Parkhill J., Toth I.K. Proc. Natl. Acad. Sci. U.S.A. 101:11105-11110(2004) [PubMed: 15263089] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SCRI 1043 / ATCC BAA-672.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX950851 Genomic DNA. Translation: CAG75780.1.
RefSeq	YP_050971.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2884540.
GenomeReviews	Gene locus ECA2880 in contig BX950851_GR.
KEGG	eca:ECA2880.
NMPDR	fig|218491.3.peg.947.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6D364.
OMA	TSNIGRM.
Enzyme and pathway databases
BioCyc	ECAR218491:ECA2880-MON.
BRENDA	2.7.8.5. 281579.
Family and domain databases
HAMAP	MF_01437. [Tree]
InterPro	IPR000462. CDP-OH_P_trans. IPR004570. Phosphatidylglycerol_P_synth. [Graphical view]
Pfam	PF01066. CDP-OH_P_transf. 1 hit. [Graphical view]
PIRSF	PIRSF000847. Phos_ph_gly_syn. 1 hit.
TIGRFAMs	TIGR00560. pgsA. 1 hit.
PROSITE	PS00379. CDP_ALCOHOL_P_TRANSF. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGSA_ERWCT

Accession

Primary (citable) accession number: Q6D364

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	January 23, 2007
Last modified:	November 3, 2009
This is version 38 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)