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Q6D299

- THIM_PECAS

UniProt

Q6D299 - THIM_PECAS

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Protein
Hydroxyethylthiazole kinase
Gene
thiM, ECA3197
Organism
Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei52 – 521Substrate; via amide nitrogen By similarity
Binding sitei127 – 1271ATP By similarity
Binding sitei173 – 1731ATP By similarity
Binding sitei200 – 2001Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPATR218491:GJNB-3246-MONOMER.
UniPathwayiUPA00060; UER00139.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinase (EC:2.7.1.50)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name:
TH kinase
Short name:
Thz kinase
Gene namesi
Name:thiM
Ordered Locus Names:ECA3197
OrganismiPectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
Taxonomic identifieri218491 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePectobacterium
ProteomesiUP000007966: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 264264Hydroxyethylthiazole kinaseUniRule annotation
PRO_0000336555Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi218491.ECA3197.

Structurei

3D structure databases

ProteinModelPortaliQ6D299.

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.

Phylogenomic databases

eggNOGiCOG2145.
HOGENOMiHOG000114352.
KOiK00878.
OMAiKEMTLAG.
OrthoDBiEOG628F8M.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_00228. Thz_kinase.
InterProiIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF02110. HK. 1 hit.
[Graphical view]
PIRSFiPIRSF000513. Thz_kinase. 1 hit.
PRINTSiPR01099. HYETHTZKNASE.
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00694. thiM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6D299-1 [UniParc]FASTAAdd to Basket

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MNTQPADFSA AQAATSLTQF RSAAPLVHCL TNDVVQSFTA NVLLALNASP    50
AMVVDPEEAA QFSAVADALL INVGTLERTR AEAMRAAVNS AHQAGTPWVL 100
DPVAVGGLTF RTEFCRELLT WKPAAIRGNA SEIMALAGLA AQGRGVDSAD 150
DSLAALPAAR ELARQVGTIV VVTGAVDYVT DGERDIAVTG GDSMMTRVVG 200
TGCALSAVVA GFCSLEGDRL SHVTAACYVM ALAGQQATSV SQGTGSFIPH 250
FLDRLYTLRA EDLA 264
Length:264
Mass (Da):27,341
Last modified:August 16, 2004 - v1
Checksum:i19496665FE340316
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX950851 Genomic DNA. Translation: CAG76095.1.
RefSeqiWP_011094718.1. NC_004547.2.
YP_051286.1. NC_004547.2.

Genome annotation databases

EnsemblBacteriaiCAG76095; CAG76095; ECA3197.
GeneIDi2884288.
KEGGieca:ECA3197.
PATRICi20481727. VBIPecAtr54885_3239.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX950851 Genomic DNA. Translation: CAG76095.1 .
RefSeqi WP_011094718.1. NC_004547.2.
YP_051286.1. NC_004547.2.

3D structure databases

ProteinModelPortali Q6D299.
ModBasei Search...

Protein-protein interaction databases

STRINGi 218491.ECA3197.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG76095 ; CAG76095 ; ECA3197 .
GeneIDi 2884288.
KEGGi eca:ECA3197.
PATRICi 20481727. VBIPecAtr54885_3239.

Phylogenomic databases

eggNOGi COG2145.
HOGENOMi HOG000114352.
KOi K00878.
OMAi KEMTLAG.
OrthoDBi EOG628F8M.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00139 .
BioCyci PATR218491:GJNB-3246-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
HAMAPi MF_00228. Thz_kinase.
InterProi IPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF02110. HK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000513. Thz_kinase. 1 hit.
PRINTSi PR01099. HYETHTZKNASE.
SUPFAMi SSF53613. SSF53613. 1 hit.
TIGRFAMsi TIGR00694. thiM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SCRI 1043 / ATCC BAA-672.

Entry informationi

Entry nameiTHIM_PECAS
AccessioniPrimary (citable) accession number: Q6D299
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 16, 2004
Last modified: September 3, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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