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Q6D1H3

- GMHA_PECAS

UniProt

Q6D1H3 - GMHA_PECAS

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Protein
Phosphoheptose isomerase
Gene
gmhA, ECA3473
Organism
Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate By similarity.UniRule annotation

Catalytic activityi

D-sedoheptulose 7-phosphate = D-glycero-D-manno-heptose 7-phosphate.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi61 – 611Zinc By similarity
Metal bindingi65 – 651Zinc By similarity
Binding sitei65 – 651Substrate By similarity
Binding sitei124 – 1241Substrate By similarity
Metal bindingi172 – 1721Zinc By similarity
Binding sitei172 – 1721Substrate By similarity
Metal bindingi180 – 1801Zinc By similarity

GO - Molecular functioni

  1. D-sedoheptulose 7-phosphate isomerase activity Source: UniProtKB-HAMAP
  2. carbohydrate binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. D-glycero-D-manno-heptose 7-phosphate biosynthetic process Source: UniProtKB-UniPathway
  2. lipopolysaccharide core region biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciPATR218491:GJNB-3542-MONOMER.
UniPathwayiUPA00041; UER00436.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoheptose isomerase (EC:5.3.1.28)
Alternative name(s):
Sedoheptulose 7-phosphate isomerase
Gene namesi
Name:gmhA
Ordered Locus Names:ECA3473
OrganismiPectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
Taxonomic identifieri218491 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePectobacterium
ProteomesiUP000007966: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 193193Phosphoheptose isomeraseUniRule annotation
PRO_1000009065Add
BLAST

Proteomic databases

PRIDEiQ6D1H3.

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi218491.ECA3473.

Structurei

3D structure databases

ProteinModelPortaliQ6D1H3.
SMRiQ6D1H3. Positions 1-190.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 193157SIS
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni52 – 543Substrate binding By similarity
Regioni93 – 942Substrate binding By similarity
Regioni119 – 1213Substrate binding By similarity

Sequence similaritiesi

Belongs to the SIS family. GmhA subfamily.
Contains 1 SIS domain.

Phylogenomic databases

eggNOGiCOG0279.
HOGENOMiHOG000237571.
KOiK03271.
OMAiHVFSRYV.
OrthoDBiEOG6384PC.

Family and domain databases

HAMAPiMF_00067. GmhA.
InterProiIPR004515. Phosphoheptose_Isoase.
IPR001347. SIS.
[Graphical view]
PfamiPF13580. SIS_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00441. gmhA. 1 hit.
PROSITEiPS51464. SIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6D1H3-1 [UniParc]FASTAAdd to Basket

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MYQDLIRSEL KEAAETLNNF LSDDANIQSI QNAAVLLANA FKAGGKVISC    50
GNGGSHCDAM HFAEELTGRY RENRPGYPAI AISDPSHLSC VSNDFGYDFV 100
FSRYVESLGR EGDVLLGIST SGNSGNIIKA IAAAKAKGMK VITLTGKDGG 150
KMAGSADVEI RVPHFGYADR IQEIHIKAIH ILIQLIEKEM ADQ 193
Length:193
Mass (Da):20,790
Last modified:August 16, 2004 - v1
Checksum:i3F57AF263FB6EDB9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX950851 Genomic DNA. Translation: CAG76372.1.
RefSeqiYP_051563.1. NC_004547.2.

Genome annotation databases

EnsemblBacteriaiCAG76372; CAG76372; ECA3473.
GeneIDi2882938.
KEGGieca:ECA3473.
PATRICi20482311. VBIPecAtr54885_3515.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX950851 Genomic DNA. Translation: CAG76372.1 .
RefSeqi YP_051563.1. NC_004547.2.

3D structure databases

ProteinModelPortali Q6D1H3.
SMRi Q6D1H3. Positions 1-190.
ModBasei Search...

Protein-protein interaction databases

STRINGi 218491.ECA3473.

Proteomic databases

PRIDEi Q6D1H3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG76372 ; CAG76372 ; ECA3473 .
GeneIDi 2882938.
KEGGi eca:ECA3473.
PATRICi 20482311. VBIPecAtr54885_3515.

Phylogenomic databases

eggNOGi COG0279.
HOGENOMi HOG000237571.
KOi K03271.
OMAi HVFSRYV.
OrthoDBi EOG6384PC.

Enzyme and pathway databases

UniPathwayi UPA00041 ; UER00436 .
BioCyci PATR218491:GJNB-3542-MONOMER.

Family and domain databases

HAMAPi MF_00067. GmhA.
InterProi IPR004515. Phosphoheptose_Isoase.
IPR001347. SIS.
[Graphical view ]
Pfami PF13580. SIS_2. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00441. gmhA. 1 hit.
PROSITEi PS51464. SIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SCRI 1043 / ATCC BAA-672.

Entry informationi

Entry nameiGMHA_PECAS
AccessioniPrimary (citable) accession number: Q6D1H3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 16, 2004
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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