Q6D159 (UPPP_PECAS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Ordered Locus Names:	ECA3589

Organism

Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica) [Complete proteome] [HAMAP]

Taxonomic identifier

218491 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Pectobacterium › Pectobacterium atrosepticum

Protein attributes

Sequence length	272 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-HAMAP
Cellular_component	integral component of membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: UniProtKB-HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 272	272	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_0000151151
Regions
	Transmembrane	6 – 26	21	Helical; Potential
	Transmembrane	45 – 65	21	Helical; Potential
	Transmembrane	92 – 112	21	Helical; Potential
	Transmembrane	115 – 135	21	Helical; Potential
	Transmembrane	189 – 209	21	Helical; Potential
	Transmembrane	221 – 241	21	Helical; Potential
	Transmembrane	251 – 271	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6D159 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 587983992C949C6A	FASTA	272	30,155
	10 20 30 40 50 60 MTDLHSLLIA FILGVVEGLT EFLPVSSTGH MIIVGHWLGF VDEKAKTFEV IIQLGSILAV 70 80 90 100 110 120 VVMFWRRLFG LIGIHFGKVP HEGKTSGRLK LTHILLAMIP AVVLGLIFHD VIKSLFYPQN 130 140 150 160 170 180 VMYSLVIGGF LLLAAEWFKP KEPRAVGLDD ITHRQAFMIG CFQCLALWPG FSRSGATISG 190 200 210 220 230 240 GMLMGVSRYA ASEFSFILAV PMMMGATVLD LYKSWHFLSL ADVPMFAVGF VTAFVVALIA 250 260 270 IKTFLKIIKR ISFIPFAIYR FIVAGVVYMV FM

References

[1]

"Genome sequence of the enterobacterial phytopathogen Erwinia carotovora subsp. atroseptica and characterization of virulence factors." Bell K.S., Sebaihia M., Pritchard L., Holden M.T.G., Hyman L.J., Holeva M.C., Thomson N.R., Bentley S.D., Churcher L.J.C., Mungall K., Atkin R., Bason N., Brooks K., Chillingworth T., Clark K., Doggett J., Fraser A., Hance Z. , Hauser H., Jagels K., Moule S., Norbertczak H., Ormond D., Price C., Quail M.A., Sanders M., Walker D., Whitehead S., Salmond G.P.C., Birch P.R.J., Parkhill J., Toth I.K. Proc. Natl. Acad. Sci. U.S.A. 101:11105-11110(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SCRI 1043 / ATCC BAA-672.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX950851 Genomic DNA. Translation: CAG76487.1.
RefSeq	YP_051677.1. NC_004547.2.
3D structure databases
ModBase	Search...
MobiDB	Search...
Protein-protein interaction databases
STRING	218491.ECA3589.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAG76487; CAG76487; ECA3589.
GeneID	2882171.
KEGG	eca:ECA3589.
PATRIC	20482573. VBIPecAtr54885_3640.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218356.
KO	K06153.
OMA	AQCFALI.
OrthoDB	EOG6QP13M.
ProtClustDB	PRK00281.
Enzyme and pathway databases
BioCyc	PATR218491:GJNB-3663-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. UppP. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP_PECAS

Accession

Primary (citable) accession number: Q6D159

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	August 16, 2004
Last modified:	April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program