uppP

Functionⁱ

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Catalytic activityⁱ

Ditrans,octacis-undecaprenyl diphosphate + H₂O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functionⁱ

undecaprenyl-diphosphatase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell wall organization Source: UniProtKB-KW
dephosphorylation Source: InterPro
peptidoglycan biosynthetic process Source: UniProtKB-KW
regulation of cell shape Source: UniProtKB-KW
response to antibiotic Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Biological process	Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCycⁱ	PATR218491:G1G3T-3682-MONOMER.

BioCycⁱ

PATR218491:G1G3T-3682-MONOMER.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation) Alternative name(s): Bacitracin resistance proteinUniRule annotation Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesⁱ	Name:uppPUniRule annotation Ordered Locus Names:ECA3589
Organismⁱ	Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
Taxonomic identifierⁱ	218491 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Pectobacteriaceae › Pectobacterium › Pectobacterium atrosepticum
Proteomesⁱ	UP000007966 Componentⁱ: Chromosome

Subcellular locationⁱ

Cell inner membrane
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_01006
; Multi-pass membrane protein
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_01006

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	6 – 26	HelicalUniRule annotationAdd BLAST	21
Transmembraneⁱ	45 – 65	HelicalUniRule annotationAdd BLAST	21
Transmembraneⁱ	92 – 112	HelicalUniRule annotationAdd BLAST	21
Transmembraneⁱ	115 – 135	HelicalUniRule annotationAdd BLAST	21
Transmembraneⁱ	189 – 209	HelicalUniRule annotationAdd BLAST	21
Transmembraneⁱ	221 – 241	HelicalUniRule annotationAdd BLAST	21
Transmembraneⁱ	251 – 271	HelicalUniRule annotationAdd BLAST	21

GO - Cellular componentⁱ

integral component of membrane Source: UniProtKB-KW
plasma membrane Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cell inner membrane, Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000151151	1 – 272	Undecaprenyl-diphosphataseAdd BLAST		272

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	218491.ECA3589.

STRINGⁱ

218491.ECA3589.

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the UppP family.UniRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG4105DWR. Bacteria. COG1968. LUCA.
HOGENOMⁱ	HOG000218356.
KEGG Orthology (KO) More...KOⁱ	K06153.
OMAⁱ	PDARMGW.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H00ZR.

Family and domain databases

HAMAPⁱ	MF_01006. Undec_diphosphatase. 1 hit.
InterProⁱ	View protein in InterPro IPR003824. UppP.
PANTHERⁱ	PTHR30622. PTHR30622. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02673. BacA. 1 hit.
TIGRFAMsⁱ	TIGR00753. undec_PP_bacA. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q6D159-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTDLHSLLIA FILGVVEGLT EFLPVSSTGH MIIVGHWLGF VDEKAKTFEV 
        60         70         80         90        100
IIQLGSILAV VVMFWRRLFG LIGIHFGKVP HEGKTSGRLK LTHILLAMIP 
       110        120        130        140        150
AVVLGLIFHD VIKSLFYPQN VMYSLVIGGF LLLAAEWFKP KEPRAVGLDD 
       160        170        180        190        200
ITHRQAFMIG CFQCLALWPG FSRSGATISG GMLMGVSRYA ASEFSFILAV 
       210        220        230        240        250
PMMMGATVLD LYKSWHFLSL ADVPMFAVGF VTAFVVALIA IKTFLKIIKR 
       260        270 
ISFIPFAIYR FIVAGVVYMV FM

Length:272

Mass (Da):30,155

Last modified:August 16, 2004 - v1

Checksum:ⁱ587983992C949C6A

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BX950851 Genomic DNA. Translation: CAG76487.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_011095092.1. NC_004547.2.

Genome annotation databases

EnsemblBacteriaⁱ	CAG76487; CAG76487; ECA3589.
KEGGⁱ	eca:ECA3589.
PATRICⁱ	fig\|218491.5.peg.3640.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q6D159	C6DDL8 A0A221T5W4 A0A0J6AH33 A0A2I1BHM1 A0A0G4JW61 A0A1D7YX82 A0A2D3MRN8 A0A0M2EX46 A0A086EPR9 A0A093SFZ7 +18	Pectobacterium carotovorum subsp. carotovorum (strain PC1) Pectobacterium carotovorum (Erwinia carotovora) Pectobacterium carotovorum subsp. carotovorum UGC32 Pectobacterium peruviense Brenneria goodwinii Pectobacterium wasabiae CFBP 3304 Pectobacterium carotovorum subsp. brasiliense Pectobacterium carotovorum subsp. carotovorum (Erwinia carotovora subsp. carotovora) Pectobacterium sp. (strain SCC3193) Pectobacterium parmentieri (strain WPP163) (Pectobacterium wasabiae (strain WPP163)) And more	272	UniRef90_Q6D159	Cluster: Undecaprenyl-diphosphatase	29

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q6D159	A1JQW4 A0A0T9SDF1 A0A0U1I9I1 C4SBR1 A0A2G4UGI4 A0A0T7NTW9 UPI00066FFF00 A0A0T9RTT3 A0A0T9T6M3 A0A0U1KBZ4 +840	Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081) Yersinia enterocolitica Yersinia mollaretii Yersinia mollaretii ATCC 43969 Yersinia Yersinia bercovieri Yersinia nurmii Yersinia entomophaga Yersinia kristensenii Yersinia enterocolitica LC20 And more	272	UniRef50_A1JQW4	Cluster: Undecaprenyl-diphosphatase	851

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BX950851 Genomic DNA. Translation: CAG76487.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_011095092.1. NC_004547.2.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	218491.ECA3589.

STRINGⁱ

218491.ECA3589.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	CAG76487; CAG76487; ECA3589.
KEGGⁱ	eca:ECA3589.
PATRICⁱ	fig\|218491.5.peg.3640.

Phylogenomic databases

eggNOGⁱ	ENOG4105DWR. Bacteria. COG1968. LUCA.
HOGENOMⁱ	HOG000218356.
KEGG Orthology (KO) More...KOⁱ	K06153.
OMAⁱ	PDARMGW.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H00ZR.

Enzyme and pathway databases

BioCycⁱ	PATR218491:G1G3T-3682-MONOMER.

BioCycⁱ

PATR218491:G1G3T-3682-MONOMER.

Family and domain databases

HAMAPⁱ	MF_01006. Undec_diphosphatase. 1 hit.
InterProⁱ	View protein in InterPro IPR003824. UppP.
PANTHERⁱ	PTHR30622. PTHR30622. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02673. BacA. 1 hit.
TIGRFAMsⁱ	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	UPPP_PECAS
Accessionⁱ	Q6D159Primary (citable) accession number: Q6D159
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
	Last sequence update:	August 16, 2004
	Last modified:	February 28, 2018
	This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6D159 (UPPP_PECAS)

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Undecaprenyl-diphosphatase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ