UniProtKB - Q6D159 (UPPP_PECAS)
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Protein
Undecaprenyl-diphosphatase
Gene
uppP
Organism
Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
Status
Functioni
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation
Miscellaneous
Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
Catalytic activityi
Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation
GO - Molecular functioni
- undecaprenyl-diphosphatase activity Source: UniProtKB-EC
GO - Biological processi
- cell wall organization Source: UniProtKB-KW
- dephosphorylation Source: InterPro
- peptidoglycan biosynthetic process Source: UniProtKB-KW
- regulation of cell shape Source: UniProtKB-KW
- response to antibiotic Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase |
Biological process | Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis |
Enzyme and pathway databases
BioCyci | PATR218491:G1G3T-3682-MONOMER. |
Names & Taxonomyi
Protein namesi | Recommended name: Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)Alternative name(s): Bacitracin resistance proteinUniRule annotation Undecaprenyl pyrophosphate phosphataseUniRule annotation |
Gene namesi | Name:uppPUniRule annotation Ordered Locus Names:ECA3589 |
Organismi | Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica) |
Taxonomic identifieri | 218491 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Pectobacteriaceae › Pectobacterium › |
Proteomesi |
|
Subcellular locationi
- Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 6 – 26 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 45 – 65 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 92 – 112 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 115 – 135 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 189 – 209 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 221 – 241 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 251 – 271 | HelicalUniRule annotationAdd BLAST | 21 |
GO - Cellular componenti
- integral component of membrane Source: UniProtKB-KW
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000151151 | 1 – 272 | Undecaprenyl-diphosphataseAdd BLAST | 272 |
Family & Domainsi
Sequence similaritiesi
Belongs to the UppP family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG4105DWR. Bacteria. COG1968. LUCA. |
HOGENOMi | HOG000218356. |
KOi | K06153. |
OMAi | PDARMGW. |
OrthoDBi | POG091H00ZR. |
Family and domain databases
HAMAPi | MF_01006. Undec_diphosphatase. 1 hit. |
InterProi | View protein in InterPro IPR003824. UppP. |
PANTHERi | PTHR30622. PTHR30622. 1 hit. |
Pfami | View protein in Pfam PF02673. BacA. 1 hit. |
TIGRFAMsi | TIGR00753. undec_PP_bacA. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q6D159-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTDLHSLLIA FILGVVEGLT EFLPVSSTGH MIIVGHWLGF VDEKAKTFEV
60 70 80 90 100
IIQLGSILAV VVMFWRRLFG LIGIHFGKVP HEGKTSGRLK LTHILLAMIP
110 120 130 140 150
AVVLGLIFHD VIKSLFYPQN VMYSLVIGGF LLLAAEWFKP KEPRAVGLDD
160 170 180 190 200
ITHRQAFMIG CFQCLALWPG FSRSGATISG GMLMGVSRYA ASEFSFILAV
210 220 230 240 250
PMMMGATVLD LYKSWHFLSL ADVPMFAVGF VTAFVVALIA IKTFLKIIKR
260 270
ISFIPFAIYR FIVAGVVYMV FM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX950851 Genomic DNA. Translation: CAG76487.1. |
RefSeqi | WP_011095092.1. NC_004547.2. |
Genome annotation databases
EnsemblBacteriai | CAG76487; CAG76487; ECA3589. |
KEGGi | eca:ECA3589. |
PATRICi | fig|218491.5.peg.3640. |
Similar proteinsi
Entry informationi
Entry namei | UPPP_PECAS | |
Accessioni | Q6D159Primary (citable) accession number: Q6D159 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 4, 2005 |
Last sequence update: | August 16, 2004 | |
Last modified: | February 28, 2018 | |
This is version 82 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |