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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathway: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi), Glucose-6-phosphate isomerase (pgi)
  3. 6-phosphofructokinase (ECA2352), ATP-dependent 6-phosphofructokinase (pfkA)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei355 – 3551Proton donorUniRule annotation
Active sitei386 – 3861UniRule annotation
Active sitei514 – 5141UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciPATR218491:GJNB-4057-MONOMER.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:ECA3979
OrganismiPectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
Taxonomic identifieri218491 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePectobacterium
ProteomesiUP000007966 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 549549Glucose-6-phosphate isomerasePRO_0000180640Add
BLAST

Proteomic databases

PRIDEiQ6D022.

Interactioni

Protein-protein interaction databases

STRINGi218491.ECA3979.

Structurei

3D structure databases

ProteinModelPortaliQ6D022.
SMRiQ6D022. Positions 7-548.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000261371.
KOiK01810.
OMAiFELANDC.
OrthoDBiEOG64R61J.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6D022-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNINPSQTA AWQALQTHFD AMKDVKISEL FAQDSDRFAH FSATFDDQML
60 70 80 90 100
VDYSKNRITA ETMGKLHALA RETDLPAAIH AMFAGEKINR TEDRAVLHVA
110 120 130 140 150
LRNRSNTPIL VDGKDVMPEV NAVLAKMKDF SERVIGGEWK GYTGKTITDV
160 170 180 190 200
VNIGIGGSDL GPFMVTEALK PYKNHLNMHF VSNVDGTHIA ETLKPLNPET
210 220 230 240 250
TLFLVASKTF TTQETMTNAH SARDWFLKTA QDEKHVAKHF AALSTNAKAV
260 270 280 290 300
GEFGIDTNNM FEFWDWVGGR YSLWSAIGLS IILSLGFDNF EKLLSGAHAM
310 320 330 340 350
DKHFASTPAE KNLPVLLALI GIWYNNFFGA ETEAILPYDQ YMHRFAAYFQ
360 370 380 390 400
QGNMESNGKS TDRNGNPVDY QTGPIIWGEP GTNGQHAFYQ LIHQGTKLVP
410 420 430 440 450
CDFIAPATSH NPLSDHHSKL LSNFFAQTEA LAFGKSREVV EAEFTAAGKS
460 470 480 490 500
AKEVEHVAPF KVFEGNRPTN SILLRDITPY SLGALIALYE HKIFTQGAIL
510 520 530 540
NIFTFDQWGV ELGKQLANRI LPELESDSTI DSHDSSTNGL INRFKAWRN
Length:549
Mass (Da):61,124
Last modified:August 16, 2004 - v1
Checksum:i090BFA73157F4B87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX950851 Genomic DNA. Translation: CAG76876.1.
RefSeqiWP_011095473.1. NC_004547.2.
YP_052066.1. NC_004547.2.

Genome annotation databases

EnsemblBacteriaiCAG76876; CAG76876; ECA3979.
GeneIDi2885797.
KEGGieca:ECA3979.
PATRICi20483387. VBIPecAtr54885_4044.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX950851 Genomic DNA. Translation: CAG76876.1.
RefSeqiWP_011095473.1. NC_004547.2.
YP_052066.1. NC_004547.2.

3D structure databases

ProteinModelPortaliQ6D022.
SMRiQ6D022. Positions 7-548.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi218491.ECA3979.

Proteomic databases

PRIDEiQ6D022.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAG76876; CAG76876; ECA3979.
GeneIDi2885797.
KEGGieca:ECA3979.
PATRICi20483387. VBIPecAtr54885_4044.

Phylogenomic databases

HOGENOMiHOG000261371.
KOiK01810.
OMAiFELANDC.
OrthoDBiEOG64R61J.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
BioCyciPATR218491:GJNB-4057-MONOMER.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SCRI 1043 / ATCC BAA-672.

Entry informationi

Entry nameiG6PI_PECAS
AccessioniPrimary (citable) accession number: Q6D022
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: August 16, 2004
Last modified: April 29, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.