Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphoglycolate phosphatase

Gene

ECA4088

Organism
Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.UniRule annotation

Catalytic activityi

2-phosphoglycolate + H2O = glycolate + phosphate.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotation
  • chlorideUniRule annotation

Pathwayi: glycolate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes glycolate from 2-phosphoglycolate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Phosphoglycolate phosphatase (ECA4088)
This subpathway is part of the pathway glycolate biosynthesis, which is itself part of Organic acid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes glycolate from 2-phosphoglycolate, the pathway glycolate biosynthesis and in Organic acid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei13NucleophileUniRule annotation1
Metal bindingi13MagnesiumUniRule annotation1
Metal bindingi15MagnesiumUniRule annotation1
Metal bindingi175MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

Chloride, Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00865; UER00834.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycolate phosphataseUniRule annotation (EC:3.1.3.18UniRule annotation)
Short name:
PGPUniRule annotation
Short name:
PGPaseUniRule annotation
Gene namesi
Ordered Locus Names:ECA4088
OrganismiPectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
Taxonomic identifieri218491 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesPectobacteriaceaePectobacterium
Proteomesi
  • UP000007966 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002381571 – 234Phosphoglycolate phosphataseAdd BLAST234

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi218491.ECA4088.

Structurei

3D structure databases

ProteinModelPortaliQ6CZR3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108VXP. Bacteria.
COG0546. LUCA.
HOGENOMiHOG000248344.
KOiK01091.
OMAiHPAPLFL.
OrthoDBiPOG091H010N.

Family and domain databases

Gene3Di1.10.150.240. 1 hit.
3.40.50.1000. 1 hit.
HAMAPiMF_00495. GPH_hydrolase_bact. 1 hit.
InterProiIPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR006346. PGP_bact.
IPR023198. PGP_dom2.
[Graphical view]
PfamiPF13419. HAD_2. 1 hit.
[Graphical view]
PRINTSiPR00413. HADHALOGNASE.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01549. HAD-SF-IA-v1. 1 hit.
TIGR01509. HAD-SF-IA-v3. 1 hit.
TIGR01449. PGP_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6CZR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELTAIRGL AFDLDGTLIH SAPGLAAAID QALVAQSLPA AGESRVATWI
60 70 80 90 100
GNGADVMVER ALRWAGVEPT AARVQETRER FDSYYAQTVD SGSTLFLQVK
110 120 130 140 150
ETLAQLAQQG VPMAVVTNKP TPFVAPLLAG LGIGDYFSLI IGGDDVIVKK
160 170 180 190 200
PHPAPLYLVL GKLGLRASEL LFVGDSRNDI QAAQAAGCRS VGMTYGYNYG
210 220 230
EAIELSQPDV VLDRFADILP LIGHSSSHNQ EPLV
Length:234
Mass (Da):24,799
Last modified:August 16, 2004 - v1
Checksum:i1942C42B879EB893
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX950851 Genomic DNA. Translation: CAG76985.1.
RefSeqiWP_011095562.1. NC_004547.2.

Genome annotation databases

EnsemblBacteriaiCAG76985; CAG76985; ECA4088.
GeneIDi2885365.
KEGGieca:ECA4088.
PATRICi20483625. VBIPecAtr54885_4158.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX950851 Genomic DNA. Translation: CAG76985.1.
RefSeqiWP_011095562.1. NC_004547.2.

3D structure databases

ProteinModelPortaliQ6CZR3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi218491.ECA4088.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAG76985; CAG76985; ECA4088.
GeneIDi2885365.
KEGGieca:ECA4088.
PATRICi20483625. VBIPecAtr54885_4158.

Phylogenomic databases

eggNOGiENOG4108VXP. Bacteria.
COG0546. LUCA.
HOGENOMiHOG000248344.
KOiK01091.
OMAiHPAPLFL.
OrthoDBiPOG091H010N.

Enzyme and pathway databases

UniPathwayiUPA00865; UER00834.

Family and domain databases

Gene3Di1.10.150.240. 1 hit.
3.40.50.1000. 1 hit.
HAMAPiMF_00495. GPH_hydrolase_bact. 1 hit.
InterProiIPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR006346. PGP_bact.
IPR023198. PGP_dom2.
[Graphical view]
PfamiPF13419. HAD_2. 1 hit.
[Graphical view]
PRINTSiPR00413. HADHALOGNASE.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01549. HAD-SF-IA-v1. 1 hit.
TIGR01509. HAD-SF-IA-v3. 1 hit.
TIGR01449. PGP_bact. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGPH_PECAS
AccessioniPrimary (citable) accession number: Q6CZR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: August 16, 2004
Last modified: November 2, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.