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Protein

Rhomboid protease GlpG

Gene

glpG

Organism
Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Rhomboid-type serine protease that catalyzes intramembrane proteolysis.UniRule annotation

Catalytic activityi

Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei201NucleophileUniRule annotation1
Active sitei254UniRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS54.016.

Names & Taxonomyi

Protein namesi
Recommended name:
Rhomboid protease GlpGUniRule annotation (EC:3.4.21.105UniRule annotation)
Alternative name(s):
Intramembrane serine proteaseUniRule annotation
Gene namesi
Name:glpGUniRule annotation
Ordered Locus Names:ECA4138
OrganismiPectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
Taxonomic identifieri218491 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesPectobacteriaceaePectobacterium
Proteomesi
  • UP000007966 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei94 – 114HelicalUniRule annotationAdd BLAST21
Transmembranei142 – 162HelicalUniRule annotationAdd BLAST21
Transmembranei168 – 188HelicalUniRule annotationAdd BLAST21
Transmembranei193 – 213HelicalUniRule annotationAdd BLAST21
Transmembranei229 – 249HelicalUniRule annotationAdd BLAST21
Transmembranei250 – 270HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003216781 – 276Rhomboid protease GlpGAdd BLAST276

Interactioni

Protein-protein interaction databases

STRINGi218491.ECA4138.

Structurei

3D structure databases

ProteinModelPortaliQ6CZL3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S54 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105EBW. Bacteria.
COG0705. LUCA.
HOGENOMiHOG000269640.
KOiK02441.
OMAiHFSAMHI.
OrthoDBiPOG091H059R.

Family and domain databases

Gene3Di1.20.1540.10. 1 hit.
HAMAPiMF_01594. Rhomboid_GlpG. 1 hit.
InterProiIPR022732. Peptidase_S54_GlpG_N.
IPR002610. Peptidase_S54_rhomboid.
IPR022764. Peptidase_S54_rhomboid_dom.
IPR023662. Rhomboid_protease_GlpG.
[Graphical view]
PANTHERiPTHR22936. PTHR22936. 1 hit.
PfamiPF01694. Rhomboid. 1 hit.
PF12122. Rhomboid_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR04239. rhombo_GlpG. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6CZL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRVIALSNP RLAQAFVDYM RTQQVHLDMR PQGHEAELWL EDETQLSKVQ
60 70 80 90 100
EALEIFLRDP TNPRYLAASW QTGSMDTGIQ YQRYSYLQTL KQKAGPLTLS
110 120 130 140 150
VMVVTIAVFI LMQISGYESV MTWLAFPAEG QQLQLWRWFS HALLHFSLLH
160 170 180 190 200
ILFNLMWWWY LGGPVEKVLG TGKLLVIALV SALVSGWAQS WCSGTYFGGL
210 220 230 240 250
SGVVYALMGY VWLRGEREPD GYLSMPRSLM AFALLWLVAG YFDILGMSIA
260 270
NAAHVAGLIV GLLMAFWDTY NKTNPR
Length:276
Mass (Da):31,324
Last modified:February 26, 2008 - v2
Checksum:iC372AA56A331302D
GO

Sequence cautioni

The sequence CAG77035 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX950851 Genomic DNA. Translation: CAG77035.1. Different initiation.

Genome annotation databases

EnsemblBacteriaiCAG77035; CAG77035; ECA4138.
KEGGieca:ECA4138.
PATRICi20483727. VBIPecAtr54885_4209.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX950851 Genomic DNA. Translation: CAG77035.1. Different initiation.

3D structure databases

ProteinModelPortaliQ6CZL3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi218491.ECA4138.

Protein family/group databases

MEROPSiS54.016.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAG77035; CAG77035; ECA4138.
KEGGieca:ECA4138.
PATRICi20483727. VBIPecAtr54885_4209.

Phylogenomic databases

eggNOGiENOG4105EBW. Bacteria.
COG0705. LUCA.
HOGENOMiHOG000269640.
KOiK02441.
OMAiHFSAMHI.
OrthoDBiPOG091H059R.

Family and domain databases

Gene3Di1.20.1540.10. 1 hit.
HAMAPiMF_01594. Rhomboid_GlpG. 1 hit.
InterProiIPR022732. Peptidase_S54_GlpG_N.
IPR002610. Peptidase_S54_rhomboid.
IPR022764. Peptidase_S54_rhomboid_dom.
IPR023662. Rhomboid_protease_GlpG.
[Graphical view]
PANTHERiPTHR22936. PTHR22936. 1 hit.
PfamiPF01694. Rhomboid. 1 hit.
PF12122. Rhomboid_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR04239. rhombo_GlpG. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGLPG_PECAS
AccessioniPrimary (citable) accession number: Q6CZL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: November 2, 2016
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.