ID   Q6CZG4_PECAS            Unreviewed;       852 AA.
AC   Q6CZG4;
DT   16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT   16-AUG-2004, sequence version 1.
DT   27-MAR-2024, entry version 92.
DE   RecName: Full=Adenylate cyclase {ECO:0000256|ARBA:ARBA00021420, ECO:0000256|RuleBase:RU000604};
DE            EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201, ECO:0000256|RuleBase:RU000604};
GN   Name=cyaA {ECO:0000313|EMBL:CAG77084.1};
GN   Synonyms=cya {ECO:0000313|EMBL:CAG77084.1};
GN   OrderedLocusNames=ECA4187 {ECO:0000313|EMBL:CAG77084.1};
OS   Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia
OS   carotovora subsp. atroseptica).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Pectobacteriaceae; Pectobacterium.
OX   NCBI_TaxID=218491 {ECO:0000313|EMBL:CAG77084.1, ECO:0000313|Proteomes:UP000007966};
RN   [1] {ECO:0000313|EMBL:CAG77084.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SCRI1043 {ECO:0000313|EMBL:CAG77084.1};
RA   Bell K.S., Sebaihia M., Pritchard L., Holden M., Hyman L.J., Holeva M.C.,
RA   Thomson N.R., Bentley S.D., Churcher C., Mungall K., Atkin R., Bason N.,
RA   Brooks K., Chillingworth T., Clark K., Doggett J., Fraser A., Hance Z.,
RA   Hauser H., Jagels K., Moule S., Norbertczak H., Ormond D., Price C.,
RA   Quail M.A., Sanders M., Walker D., Whitehead S., Salmond G.P.C.,
RA   Birch P.R.J., Barrell B.G., Parkhill J., Toth I.K.;
RT   "The genome sequence of the enterobacterial phytopathogen Erwinia
RT   carotovora subsp. atroseptica SCRI1043 and functional genomic
RT   identification of novel virulence factors.";
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001593,
CC         ECO:0000256|RuleBase:RU000604};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC       ECO:0000256|RuleBase:RU000604}.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-1 family.
CC       {ECO:0000256|ARBA:ARBA00007901, ECO:0000256|RuleBase:RU004184}.
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DR   EMBL; BX950851; CAG77084.1; -; Genomic_DNA.
DR   RefSeq; WP_011095658.1; NC_004547.2.
DR   AlphaFoldDB; Q6CZG4; -.
DR   STRING; 218491.ECA4187; -.
DR   KEGG; eca:ECA4187; -.
DR   PATRIC; fig|218491.5.peg.4260; -.
DR   eggNOG; COG3072; Bacteria.
DR   HOGENOM; CLU_013280_0_0_6; -.
DR   OrthoDB; 5571448at2; -.
DR   Proteomes; UP000007966; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006171; P:cAMP biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR000274; Adenylate_cyclase_1.
DR   InterPro; IPR024686; Adenylate_cyclase_1_CS.
DR   InterPro; IPR024685; Adenylate_cyclase_1_N.
DR   PANTHER; PTHR38760; ADENYLATE CYCLASE; 1.
DR   PANTHER; PTHR38760:SF1; ADENYLATE CYCLASE; 1.
DR   Pfam; PF12633; Adenyl_cycl_N; 1.
DR   Pfam; PF01295; Adenylate_cycl; 1.
DR   PIRSF; PIRSF001444; Adenylate_cycl; 1.
DR   PROSITE; PS01092; ADENYLATE_CYCLASE_1_1; 1.
DR   PROSITE; PS01093; ADENYLATE_CYCLASE_1_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   cAMP biosynthesis {ECO:0000256|ARBA:ARBA00022998,
KW   ECO:0000256|RuleBase:RU000604}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000604};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007966}.
FT   DOMAIN          5..200
FT                   /note="Adenylate cyclase class-I N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12633"
SQ   SEQUENCE   852 AA;  97685 MW;  7B11E317BD689B48 CRC64;
     MYFYIETLKQ RLDAINQLRV ERALGAMKPA FQQVYSLLPI LLHHHHPLMP GYLEGKVPHG
     VCTHTPDEKQ QQYLDSIALR WGQFDGSHPQ GELPITGIYS MGSTSSIGQS CSSDLDIWVC
     HQSWLDSEER QLLQKKCTLL EQWAAAQGAE VSFFLMDESR FRHNESGSLG GEDCGSMQHI
     LLLDEFYRTA VRMAGKRILW NMVPVEEESH YDDYVLSLYS QGALAPNEWM DLGGLSTLSA
     EEYFGASLWQ LYKSIDSPYK AVLKTLLLEA YSWEYPDTSL LSTEIKKRLH DGEIVSFGLD
     PYCMMLDRVT HYLTAINDPT RLDLARRCFY LKVCEKLSRE QACVGWRRQI LSQLVQEWGW
     SDEHLAMLDN RANWKIEQVR EAHNELLDAM MQTYRNLIRF ARRNNLSVSA SPQDIGVLTR
     KLYAAFEALP GKVTLLNPQI SPDLSEPNLT FIYVPPGRAN RSGWYLYNQA PSMDAIISHQ
     PLEYNRYLNK LVAWAYFNGL LTPSTRLYIK GNELCDITRL QALVDDVANH FPLRVPAPTP
     KALYSPCEIR HLAIIVNLEH DPTAAFRNQV VHFDFRHLDV FSFGQQQQCL VGSIDLLYRN
     SWNEVRTLHF SGEQAVLEAL KTILGKMHQD AALPESLEVF CYSQHLRGLI RTRVQQLVSE
     CIELRLTSTR QQEPGRFKAV KVAGQTWGLF FERLSVSVQK LENAVEFYGA ISNNKLQGQP
     VQVETNHVHL PPVVDGVASE GIIQFFFEDL TENQGFNIYI LDESNRVEVY HHCEGSKEEL
     VRDVSRFYSS SHDRFTYGSS FINFNLPQFY QIVQLDGRTQ VIPFRSSALS HLCITPVVDD
     EVMTMEQRLQ IL
//