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Q6CZD8

- GPPA_PECAS

UniProt

Q6CZD8 - GPPA_PECAS

Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

    Catalytic activityi

    Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. exopolyphosphatase activity Source: InterPro
    2. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC
    3. magnesium ion binding Source: InterPro

    GO - Biological processi

    1. guanosine pentaphosphate catabolic process Source: InterPro
    2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
    3. polyphosphate catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciPATR218491:GJNB-4303-MONOMER.
    UniPathwayiUPA00908; UER00884.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
    Alternative name(s):
    Guanosine pentaphosphate phosphohydrolaseUniRule annotation
    pppGpp-5'-phosphohydrolaseUniRule annotation
    Gene namesi
    Name:gppAUniRule annotation
    Ordered Locus Names:ECA4214
    OrganismiPectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
    Taxonomic identifieri218491 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePectobacterium
    ProteomesiUP000007966: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 498498Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatasePRO_0000194279Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi218491.ECA4214.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6CZD8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0248.
    HOGENOMiHOG000258672.
    KOiK01524.
    OMAiGLHIEYK.
    OrthoDBiEOG6M6JN6.

    Family and domain databases

    HAMAPiMF_01550. GppA.
    InterProiIPR022371. Exopolyphosphatase.
    IPR023709. Guo-5TP_3DP_PyrP.
    IPR003695. Ppx_GppA.
    [Graphical view]
    PfamiPF02541. Ppx-GppA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03706. exo_poly_only. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6CZD8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSSSSLYAA IDLGSNSFHM LVTRETAGSI QTLAKIKRKV RLAAGLDKQN    50
    RLSQEAMQRG WQCLQLFSER LQDIPQDQVR VVATATLRLA TNADEFLQRA 100
    QEILGLPIQV ISGEEEARLI YQGVAHTTGG PDARLVVDIG GGSTELATGI 150
    GAKTTQLISL PMGCVTWLDR YFSDRNLEAG NFERAENAAR EMLRPVAASL 200
    REQGWQICVG ASGTVQALQE IMVAQGMDEY ITLPKLRQLK EHAIQCDKLE 250
    ELEIDGLTLE RALVFPSGLA ILLAIFQELD IKTMTLAGGA LREGLVYGML 300
    HLPVDQDIRH RTLATLQRRY LLDTEQAKRV STLADNFLQQ VARDWQLDSR 350
    CRELLRSACM VHEIGLSIDF RQSPQHAAYL IRHSDLPGFT PAQKKLLATL 400
    LQNQINPIDL MPLSQQNALP VNQAQHLCRL LRLAIIFASR RRDDTLPAVR 450
    LRVEGEALRL ILPAGWLAQH PLRAEMLEQE SRWQSYVHWP LMLEEAPA 498
    Length:498
    Mass (Da):55,719
    Last modified:August 16, 2004 - v1
    Checksum:i7AC67D354A932836
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX950851 Genomic DNA. Translation: CAG77111.1.
    RefSeqiWP_011095685.1. NC_004547.2.
    YP_052301.1. NC_004547.2.

    Genome annotation databases

    EnsemblBacteriaiCAG77111; CAG77111; ECA4214.
    GeneIDi2885504.
    KEGGieca:ECA4214.
    PATRICi20483897. VBIPecAtr54885_4290.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX950851 Genomic DNA. Translation: CAG77111.1 .
    RefSeqi WP_011095685.1. NC_004547.2.
    YP_052301.1. NC_004547.2.

    3D structure databases

    ProteinModelPortali Q6CZD8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 218491.ECA4214.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAG77111 ; CAG77111 ; ECA4214 .
    GeneIDi 2885504.
    KEGGi eca:ECA4214.
    PATRICi 20483897. VBIPecAtr54885_4290.

    Phylogenomic databases

    eggNOGi COG0248.
    HOGENOMi HOG000258672.
    KOi K01524.
    OMAi GLHIEYK.
    OrthoDBi EOG6M6JN6.

    Enzyme and pathway databases

    UniPathwayi UPA00908 ; UER00884 .
    BioCyci PATR218491:GJNB-4303-MONOMER.

    Family and domain databases

    HAMAPi MF_01550. GppA.
    InterProi IPR022371. Exopolyphosphatase.
    IPR023709. Guo-5TP_3DP_PyrP.
    IPR003695. Ppx_GppA.
    [Graphical view ]
    Pfami PF02541. Ppx-GppA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03706. exo_poly_only. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SCRI 1043 / ATCC BAA-672.

    Entry informationi

    Entry nameiGPPA_PECAS
    AccessioniPrimary (citable) accession number: Q6CZD8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3