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Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. exopolyphosphatase activity Source: InterPro
  2. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: InterPro

GO - Biological processi

  1. guanosine pentaphosphate catabolic process Source: InterPro
  2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
  3. polyphosphate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciPATR218491:GJNB-4303-MONOMER.
UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolaseUniRule annotation
pppGpp-5'-phosphohydrolaseUniRule annotation
Gene namesi
Name:gppAUniRule annotation
Ordered Locus Names:ECA4214
OrganismiPectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
Taxonomic identifieri218491 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePectobacterium
ProteomesiUP000007966: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 498498Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatasePRO_0000194279Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi218491.ECA4214.

Structurei

3D structure databases

ProteinModelPortaliQ6CZD8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0248.
HOGENOMiHOG000258672.
KOiK01524.
OMAiFKRAPQH.
OrthoDBiEOG6M6JN6.

Family and domain databases

HAMAPiMF_01550. GppA.
InterProiIPR022371. Exopolyphosphatase.
IPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03706. exo_poly_only. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6CZD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSSSSLYAA IDLGSNSFHM LVTRETAGSI QTLAKIKRKV RLAAGLDKQN
60 70 80 90 100
RLSQEAMQRG WQCLQLFSER LQDIPQDQVR VVATATLRLA TNADEFLQRA
110 120 130 140 150
QEILGLPIQV ISGEEEARLI YQGVAHTTGG PDARLVVDIG GGSTELATGI
160 170 180 190 200
GAKTTQLISL PMGCVTWLDR YFSDRNLEAG NFERAENAAR EMLRPVAASL
210 220 230 240 250
REQGWQICVG ASGTVQALQE IMVAQGMDEY ITLPKLRQLK EHAIQCDKLE
260 270 280 290 300
ELEIDGLTLE RALVFPSGLA ILLAIFQELD IKTMTLAGGA LREGLVYGML
310 320 330 340 350
HLPVDQDIRH RTLATLQRRY LLDTEQAKRV STLADNFLQQ VARDWQLDSR
360 370 380 390 400
CRELLRSACM VHEIGLSIDF RQSPQHAAYL IRHSDLPGFT PAQKKLLATL
410 420 430 440 450
LQNQINPIDL MPLSQQNALP VNQAQHLCRL LRLAIIFASR RRDDTLPAVR
460 470 480 490
LRVEGEALRL ILPAGWLAQH PLRAEMLEQE SRWQSYVHWP LMLEEAPA
Length:498
Mass (Da):55,719
Last modified:August 16, 2004 - v1
Checksum:i7AC67D354A932836
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX950851 Genomic DNA. Translation: CAG77111.1.
RefSeqiYP_052301.1. NC_004547.2.

Genome annotation databases

EnsemblBacteriaiCAG77111; CAG77111; ECA4214.
GeneIDi2885504.
KEGGieca:ECA4214.
PATRICi20483897. VBIPecAtr54885_4290.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX950851 Genomic DNA. Translation: CAG77111.1.
RefSeqiYP_052301.1. NC_004547.2.

3D structure databases

ProteinModelPortaliQ6CZD8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi218491.ECA4214.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAG77111; CAG77111; ECA4214.
GeneIDi2885504.
KEGGieca:ECA4214.
PATRICi20483897. VBIPecAtr54885_4290.

Phylogenomic databases

eggNOGiCOG0248.
HOGENOMiHOG000258672.
KOiK01524.
OMAiFKRAPQH.
OrthoDBiEOG6M6JN6.

Enzyme and pathway databases

UniPathwayiUPA00908; UER00884.
BioCyciPATR218491:GJNB-4303-MONOMER.

Family and domain databases

HAMAPiMF_01550. GppA.
InterProiIPR022371. Exopolyphosphatase.
IPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03706. exo_poly_only. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SCRI 1043 / ATCC BAA-672.

Entry informationi

Entry nameiGPPA_PECAS
AccessioniPrimary (citable) accession number: Q6CZD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: August 16, 2004
Last modified: February 4, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.