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Q6CZD8 (GPPA_PECAS) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

EC=3.6.1.40
Alternative name(s):
Guanosine pentaphosphate phosphohydrolase
pppGpp-5'-phosphohydrolase
Gene names
Name:gppA
Ordered Locus Names:ECA4214
OrganismPectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica) [Complete proteome] [HAMAP]
Taxonomic identifier218491 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePectobacterium

Protein attributes

Sequence length498 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities By similarity. HAMAP-Rule MF_01550

Catalytic activity

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate. HAMAP-Rule MF_01550

Pathway

Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2. HAMAP-Rule MF_01550

Sequence similarities

Belongs to the GppA/Ppx family. GppA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 498498Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase HAMAP-Rule MF_01550
PRO_0000194279

Sequences

Sequence LengthMass (Da)Tools
Q6CZD8 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 7AC67D354A932836

FASTA49855,719
        10         20         30         40         50         60 
MLSSSSLYAA IDLGSNSFHM LVTRETAGSI QTLAKIKRKV RLAAGLDKQN RLSQEAMQRG 

        70         80         90        100        110        120 
WQCLQLFSER LQDIPQDQVR VVATATLRLA TNADEFLQRA QEILGLPIQV ISGEEEARLI 

       130        140        150        160        170        180 
YQGVAHTTGG PDARLVVDIG GGSTELATGI GAKTTQLISL PMGCVTWLDR YFSDRNLEAG 

       190        200        210        220        230        240 
NFERAENAAR EMLRPVAASL REQGWQICVG ASGTVQALQE IMVAQGMDEY ITLPKLRQLK 

       250        260        270        280        290        300 
EHAIQCDKLE ELEIDGLTLE RALVFPSGLA ILLAIFQELD IKTMTLAGGA LREGLVYGML 

       310        320        330        340        350        360 
HLPVDQDIRH RTLATLQRRY LLDTEQAKRV STLADNFLQQ VARDWQLDSR CRELLRSACM 

       370        380        390        400        410        420 
VHEIGLSIDF RQSPQHAAYL IRHSDLPGFT PAQKKLLATL LQNQINPIDL MPLSQQNALP 

       430        440        450        460        470        480 
VNQAQHLCRL LRLAIIFASR RRDDTLPAVR LRVEGEALRL ILPAGWLAQH PLRAEMLEQE 

       490 
SRWQSYVHWP LMLEEAPA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX950851 Genomic DNA. Translation: CAG77111.1.
RefSeqYP_052301.1. NC_004547.2.

3D structure databases

ProteinModelPortalQ6CZD8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING218491.ECA4214.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAG77111; CAG77111; ECA4214.
GeneID2885504.
KEGGeca:ECA4214.
PATRIC20483897. VBIPecAtr54885_4290.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0248.
HOGENOMHOG000258672.
KOK01524.
OMAGLHIEYK.
OrthoDBEOG6M6JN6.

Enzyme and pathway databases

BioCycPATR218491:GJNB-4303-MONOMER.
UniPathwayUPA00908; UER00884.

Family and domain databases

HAMAPMF_01550. GppA.
InterProIPR022371. Exopolyphosphatase.
IPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamPF02541. Ppx-GppA. 1 hit.
[Graphical view]
TIGRFAMsTIGR03706. exo_poly_only. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGPPA_PECAS
AccessionPrimary (citable) accession number: Q6CZD8
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: August 16, 2004
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways