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Q6CYD7 (Q6CYD7_KLULA) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenosylhomocysteinase RuleBase RU000548
EC=3.3.1.1 RuleBase RU000548
Gene names
Ordered Locus Names:KLLA0A01199g
OrganismKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]
Taxonomic identifier284590 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces

Protein attributes

Sequence length449 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine. RuleBase RU000548

Cofactor

NAD By similarity. RuleBase RU000548

Pathway

Amino-acid biosynthesis; homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. RuleBase RU000548

Sequence similarities

Belongs to the adenosylhomocysteinase family. RuleBase RU004166

Ontologies

Keywords
   Biological processOne-carbon metabolism RuleBase RU000548
   LigandNAD RuleBase RU000548
   Molecular functionHydrolase RuleBase RU000548
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processone-carbon metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionadenosylhomocysteinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Binding site581Substrate By similarity PIRSR PIRSR001109-1
Binding site1341Substrate By similarity PIRSR PIRSR001109-1
Binding site1591Substrate By similarity PIRSR PIRSR001109-1
Binding site1891Substrate By similarity PIRSR PIRSR001109-1
Binding site1931Substrate By similarity PIRSR PIRSR001109-1

Sequences

Sequence LengthMass (Da)Tools
Q6CYD7 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: F99B110AA0FB1EB4

FASTA44949,189
        10         20         30         40         50         60 
MSAPAHNYKV ADISLAAFGR KEIELAEHEM PGLIAIREAY GAEQPLKGAR IAGCLHMTIQ 

        70         80         90        100        110        120 
TAVLIETLVA LGAEVTWSSC NIYSTQDHAA AAIAASGVPV FAWKGETEEE YLWCIEQQLF 

       130        140        150        160        170        180 
AFKDDKKLNL ILDDGGDLTS LVHDKYPDML MDCFGLSEET TTGVHHLYRM VKENKLKVPA 

       190        200        210        220        230        240 
INVNDSVTKS KFDNLYGCRE SLIDGIKRAT DVMLAGKVAV VAGYGDVGKG CAAALRGFGA 

       250        260        270        280        290        300 
RVIVTEIDPI NALQAAMEGY QVIPMEEAVS SGQVFVTTTG CRDIITKEHF LQMPEDAIVC 

       310        320        330        340        350        360 
NIGHFDIEID VAWLKANATE VINIKPQVDR YLLPSGKHVI LLADGRLVNL GCATGHSSFV 

       370        380        390        400        410        420 
MSCSFSNQVL AQIALFKAQD KAFREKYIEF QKTGPFDIGV HVLPKILDEA VAKFHLDNLG 

       430        440 
VKLTKLSDVQ SEYLGIPEEG PYKADHYRY

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR382121 Genomic DNA. Translation: CAH02640.1.
RefSeqXP_451052.1. XM_451052.1.

3D structure databases

ProteinModelPortalQ6CYD7.
SMRQ6CYD7. Positions 8-449.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ6CYD7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2896612.
GenomeReviewsGene locus KLLA0A01199g in contig CR382121_GR.
KEGGkla:KLLA0A01199g.

Phylogenomic databases

eggNOGfuNOG06806.
HOGENOMHBG352029.
OMAELFTKTE.
OrthoDBEOG41G6CK.

Family and domain databases

HAMAPMF_00563. AdoHcyase.
[Tree]
InterProIPR000043. Adenosylhomocysteinase.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
[Graphical view]
KOK01251.
PANTHERPTHR23420. Ad_hcy_hydrolase. 1 hit.
PfamPF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
[Graphical view]
PIRSFPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTSM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
[Graphical view]
TIGRFAMsTIGR00936. AhcY. 1 hit.
PROSITEPS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ6CYD7_KLULA
AccessionPrimary (citable) accession number: Q6CYD7
Entry history
Integrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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