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Q6CYB3 (ERG6_KLULA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Sterol 24-C-methyltransferase

EC=2.1.1.41
Alternative name(s):
Delta(24)-sterol C-methyltransferase
Gene names
Name:ERG6
Ordered Locus Names:KLLA0A01738g
OrganismKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]
Taxonomic identifier284590 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces

Protein attributes

Sequence length371 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol By similarity.

Catalytic activity

S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.

Pathway

Steroid metabolism; ergosterol biosynthesis; ergosterol from zymosterol: step 1/5.

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 371371Sterol 24-C-methyltransferase
PRO_0000124793

Sequences

Sequence LengthMass (Da)Tools
Q6CYB3 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 9A8A3437FB522959

FASTA37141,799
        10         20         30         40         50         60 
MSESNELRKR QAEFTKELHG NNVTKSGFSA LVSKNKSAQT EAVAKYLKHW DGKTDADAER 

        70         80         90        100        110        120 
RRLEDYNEST HSYYNVVTDF YEYGWGSSFH FSRFFKGESF SASVARHEHY LAYKAGIKEN 

       130        140        150        160        170        180 
DLILDVGCGV GGPARTISRF TGCNIIGLNN NDYQIQKANY YAKRDHLDSK LSFVKGDFMK 

       190        200        210        220        230        240 
MEFDENTFDS VYAIEATCHA PTFEGVYGEI YKVLKPGGTF AVYEWVMTDK YDETNPEHRK 

       250        260        270        280        290        300 
IAYEIELGDG IPKMYSVDAA RDALSKVGFE ILEENDLADN DDEIPWYAPL TGEWKYVNSV 

       310        320        330        340        350        360 
ADLATFFRTS RLGRAFTTSM VTVFEKLGLA PKGSVSVTNA LEEAAVGLVA GGEKKLFTPM 

       370 
MLFVAKKPEQ K 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382121 Genomic DNA. Translation: CAH02664.1.
RefSeqXP_451076.1. XM_451076.1.

3D structure databases

ProteinModelPortalQ6CYB3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING28985.Q6CYB3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2896594.
KEGGkla:KLLA0A01738g.

Phylogenomic databases

eggNOGCOG0500.
HOGENOMHOG000171097.
KOK00559.
OMAFHFCRFS.
OrthoDBEOG7DVDMW.

Enzyme and pathway databases

UniPathwayUPA00768; UER00760.

Family and domain databases

Gene3D3.40.50.150. 1 hit.
InterProIPR025810. ERG6.
IPR013216. Methyltransf_11.
IPR029063. SAM-dependent_MTases-like.
IPR013705. Sterol_MeTrfase_C.
[Graphical view]
PfamPF08241. Methyltransf_11. 1 hit.
PF08498. Sterol_MT_C. 1 hit.
[Graphical view]
SUPFAMSSF53335. SSF53335. 2 hits.
PROSITEPS51685. SAM_MT_ERG6_SMT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameERG6_KLULA
AccessionPrimary (citable) accession number: Q6CYB3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: August 16, 2004
Last modified: June 11, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways