Reviewed, UniProtKB/Swiss-Prot Q6CYB3 (ERG6_KLULA)

Names and origin

Protein names

Recommended name:
    Sterol 24-C-methyltransferase
    EC=2.1.1.41
Alternative name(s):
    Delta(24)-sterol C-methyltransferase

Gene names

Name:	ERG6
Ordered Locus Names:	KLLA0A01738g

Organism

Kluyveromyces lactis (Yeast) (Candida sphaerica) [Complete proteome]

Taxonomic identifier

28985 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces

Protein attributes

Sequence length	371 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol By similarity.
Catalytic activity	S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.
Pathway	Steroid metabolism; ergosterol biosynthesis; ergosterol from zymosterol: step 1/5.
Sequence similarities	Belongs to the methyltransferase superfamily. ERG6 family.

Ontologies

Keywords
Biological process	Lipid synthesis Steroid biosynthesis Sterol biosynthesis
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	sterol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	sterol 24-C-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 371	371	Sterol 24-C-methyltransferase		PRO_0000124793

Sequences

	Sequence		Length	Mass (Da)
	Q6CYB3-1 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 9A8A3437FB522959	FASTA	371	41,799
	10 20 30 40 50 60 MSESNELRKR QAEFTKELHG NNVTKSGFSA LVSKNKSAQT EAVAKYLKHW DGKTDADAER 70 80 90 100 110 120 RRLEDYNEST HSYYNVVTDF YEYGWGSSFH FSRFFKGESF SASVARHEHY LAYKAGIKEN 130 140 150 160 170 180 DLILDVGCGV GGPARTISRF TGCNIIGLNN NDYQIQKANY YAKRDHLDSK LSFVKGDFMK 190 200 210 220 230 240 MEFDENTFDS VYAIEATCHA PTFEGVYGEI YKVLKPGGTF AVYEWVMTDK YDETNPEHRK 250 260 270 280 290 300 IAYEIELGDG IPKMYSVDAA RDALSKVGFE ILEENDLADN DDEIPWYAPL TGEWKYVNSV 310 320 330 340 350 360 ADLATFFRTS RLGRAFTTSM VTVFEKLGLA PKGSVSVTNA LEEAAVGLVA GGEKKLFTPM 370 MLFVAKKPEQ K

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NRRL Y-1140 / WM37.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR382121 Genomic DNA. Translation: CAH02664.1.
RefSeq	XP_451076.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2896594.
KEGG	kla:KLLA0A01738g.
Phylogenomic databases
HOGENOM	Q6CYB3.
OMA	Q6CYB3. FVKGDFM.
Enzyme and pathway databases
BRENDA	2.1.1.41. 74088.
Family and domain databases
InterPro	IPR013216. Methyltransf_11. IPR013705. Sterol_MeTrfase_C. [Graphical view]
Pfam	PF08241. Methyltransf_11. 1 hit. PF08498. Sterol_MT_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ERG6_KLULA

Accession

Primary (citable) accession number: Q6CYB3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	August 16, 2004
Last modified:	May 5, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)