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Q6CYB3

- ERG6_KLULA

UniProt

Q6CYB3 - ERG6_KLULA

Protein

Sterol 24-C-methyltransferase

Gene

ERG6

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.

    Pathwayi

    GO - Molecular functioni

    1. sterol 24-C-methyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. sterol biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    UniPathwayiUPA00768; UER00760.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sterol 24-C-methyltransferase (EC:2.1.1.41)
    Alternative name(s):
    Delta(24)-sterol C-methyltransferase
    Gene namesi
    Name:ERG6
    Ordered Locus Names:KLLA0A01738g
    OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
    Taxonomic identifieri284590 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
    ProteomesiUP000000598: Chromosome A

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 371371Sterol 24-C-methyltransferasePRO_0000124793Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi28985.Q6CYB3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6CYB3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0500.
    HOGENOMiHOG000171097.
    KOiK00559.
    OMAiFHFCRFS.
    OrthoDBiEOG7DVDMW.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR025810. ERG6.
    IPR013216. Methyltransf_11.
    IPR029063. SAM-dependent_MTases-like.
    IPR013705. Sterol_MeTrfase_C.
    [Graphical view]
    PfamiPF08241. Methyltransf_11. 1 hit.
    PF08498. Sterol_MT_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 2 hits.
    PROSITEiPS51685. SAM_MT_ERG6_SMT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6CYB3-1 [UniParc]FASTAAdd to Basket

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    MSESNELRKR QAEFTKELHG NNVTKSGFSA LVSKNKSAQT EAVAKYLKHW    50
    DGKTDADAER RRLEDYNEST HSYYNVVTDF YEYGWGSSFH FSRFFKGESF 100
    SASVARHEHY LAYKAGIKEN DLILDVGCGV GGPARTISRF TGCNIIGLNN 150
    NDYQIQKANY YAKRDHLDSK LSFVKGDFMK MEFDENTFDS VYAIEATCHA 200
    PTFEGVYGEI YKVLKPGGTF AVYEWVMTDK YDETNPEHRK IAYEIELGDG 250
    IPKMYSVDAA RDALSKVGFE ILEENDLADN DDEIPWYAPL TGEWKYVNSV 300
    ADLATFFRTS RLGRAFTTSM VTVFEKLGLA PKGSVSVTNA LEEAAVGLVA 350
    GGEKKLFTPM MLFVAKKPEQ K 371
    Length:371
    Mass (Da):41,799
    Last modified:August 16, 2004 - v1
    Checksum:i9A8A3437FB522959
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382121 Genomic DNA. Translation: CAH02664.1.
    RefSeqiXP_451076.1. XM_451076.1.

    Genome annotation databases

    GeneIDi2896594.
    KEGGikla:KLLA0A01738g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382121 Genomic DNA. Translation: CAH02664.1 .
    RefSeqi XP_451076.1. XM_451076.1.

    3D structure databases

    ProteinModelPortali Q6CYB3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 28985.Q6CYB3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2896594.
    KEGGi kla:KLLA0A01738g.

    Phylogenomic databases

    eggNOGi COG0500.
    HOGENOMi HOG000171097.
    KOi K00559.
    OMAi FHFCRFS.
    OrthoDBi EOG7DVDMW.

    Enzyme and pathway databases

    UniPathwayi UPA00768 ; UER00760 .

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR025810. ERG6.
    IPR013216. Methyltransf_11.
    IPR029063. SAM-dependent_MTases-like.
    IPR013705. Sterol_MeTrfase_C.
    [Graphical view ]
    Pfami PF08241. Methyltransf_11. 1 hit.
    PF08498. Sterol_MT_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 2 hits.
    PROSITEi PS51685. SAM_MT_ERG6_SMT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiERG6_KLULA
    AccessioniPrimary (citable) accession number: Q6CYB3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3