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Protein

Protein-S-isoprenylcysteine O-methyltransferase

Gene

KLLA0_A02167g

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferaseUniRule annotation, Transferase
LigandS-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-S-isoprenylcysteine O-methyltransferaseUniRule annotation (EC:2.1.1.100UniRule annotation)
Gene namesi
ORF Names:KLLA0_A02167gImported
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)Imported
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
Proteomesi
  • UP000000598 Componenti: Chromosome A

Subcellular locationi

  • Endoplasmic reticulum membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei31 – 50HelicalUniRule annotationAdd BLAST20
Transmembranei94 – 113HelicalUniRule annotationAdd BLAST20
Transmembranei125 – 143HelicalUniRule annotationAdd BLAST19
Transmembranei186 – 214HelicalUniRule annotationAdd BLAST29

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation, Membrane

Interactioni

Protein-protein interaction databases

STRINGi284590.XP_451096.1.

Family & Domainsi

Sequence similaritiesi

Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG2628. Eukaryota.
COG2020. LUCA.
HOGENOMiHOG000213961.
InParanoidiQ6CY93.
KOiK00587.
OMAiLPFIRGY.
OrthoDBiEOG092C5DVA.

Family and domain databases

InterProiView protein in InterPro
IPR007269. ICMT_MeTrfase.
IPR025770. PPMT_MeTrfase.
PfamiView protein in Pfam
PF04140. ICMT. 1 hit.
PROSITEiView protein in PROSITE
PS51564. SAM_ICMT. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6CY93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRDDESED VLVIIDGKTF PNIQKNELDE ISLTAFMLGV IFGVSLITLC
60 70 80 90 100
LSPFWNFNIY MISLSIFHLL EFWITAKYNP GKLNTNSFLI NNGVGYFLAH
110 120 130 140 150
SVALIETIIE RLLFPSFKST TYSFYNEFIV TVGVVLLLLG QYVRSSAMIT
160 170 180 190 200
AGQSFSHVVK VTKNSDHTLV TSGIYSKSRH PSYFGFFWWS VGSQLMLLNP
210 220 230 240
VSLVIFIVVL WKFFNSRIAF EERYLVQFFG NQYITYRETV GVGIPFIK
Length:248
Mass (Da):28,325
Last modified:August 16, 2004 - v1
Checksum:i02CDC5F8133D3C21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382121 Genomic DNA. Translation: CAH02684.1.
RefSeqiXP_451096.1. XM_451096.1.

Genome annotation databases

EnsemblFungiiCAH02684; CAH02684; KLLA0_A02167g.
GeneIDi2896574.
KEGGikla:KLLA0A02167g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382121 Genomic DNA. Translation: CAH02684.1.
RefSeqiXP_451096.1. XM_451096.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi284590.XP_451096.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAH02684; CAH02684; KLLA0_A02167g.
GeneIDi2896574.
KEGGikla:KLLA0A02167g.

Phylogenomic databases

eggNOGiKOG2628. Eukaryota.
COG2020. LUCA.
HOGENOMiHOG000213961.
InParanoidiQ6CY93.
KOiK00587.
OMAiLPFIRGY.
OrthoDBiEOG092C5DVA.

Family and domain databases

InterProiView protein in InterPro
IPR007269. ICMT_MeTrfase.
IPR025770. PPMT_MeTrfase.
PfamiView protein in Pfam
PF04140. ICMT. 1 hit.
PROSITEiView protein in PROSITE
PS51564. SAM_ICMT. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ6CY93_KLULA
AccessioniPrimary (citable) accession number: Q6CY93
Entry historyiIntegrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: June 7, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.