Reviewed, UniProtKB/Swiss-Prot Q6CXY0 (ALG13_KLULA)

Names and origin

Protein names

Recommended name:
    UDP-N-acetylglucosamine transferase subunit ALG13
    EC=2.4.1.141
Alternative name(s):
    Asparagine-linked glycosylation protein 13

Gene names

Name:	ALG13
Ordered Locus Names:	KLLA0A04774g

Organism

Kluyveromyces lactis (Yeast) (Candida sphaerica) [Complete proteome]

Taxonomic identifier

28985 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces

Protein attributes

Sequence length	197 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway By similarity.
Catalytic activity	UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N'-diacetylchitobiosyl-diphosphodolichol.
Subunit structure	Heterodimer with ALG14 to form a functional enzyme By similarity.
Subcellular location	Endoplasmic reticulum By similarity.
Sequence similarities	Belongs to the glycosyltransferase 28 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro lipid glycosylation Inferred from electronic annotation. Source: InterPro
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity Inferred from electronic annotation. Source: EC carbohydrate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 197	197	UDP-N-acetylglucosamine transferase subunit ALG13		PRO_0000215602

Sequences

	Sequence		Length	Mass (Da)
	Q6CXY0-1 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 232E9C18DE06AE42	FASTA	197	22,234
	10 20 30 40 50 60 MNNTVLVTCG ATVSFPRLVE TVLDRSVTEK LKVLGYGRIV IQYGRGFSDT FLQLVEKHLG 70 80 90 100 110 120 LFTEKKSCGI KVLDKIENLK VISVDGIEIC GFEFSHDIEK LIANNIDLVI SHAGTGSILD 130 140 150 160 170 180 SLRVGKKLIV VVNDTLMDNH QQLIADKFEQ QKLLWSVHAN TEELLRALDR SENEELLKID 190 NTYNKQFEKL LYNVAID

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NRRL Y-1140 / WM37.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR382121 Genomic DNA. Translation: CAH02797.1.
RefSeq	XP_451209.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q6CXY0.
Genome annotation databases
GeneID	2896531.
GenomeReviews	Gene locus KLLA0A04774g in contig CR382121_GR.
KEGG	kla:KLLA0A04774g.
Phylogenomic databases
HOGENOM	Q6CXY0.
OMA	PLIVCVN.
Enzyme and pathway databases
BRENDA	2.4.1.141. 74088.
Family and domain databases
InterPro	IPR007235. Glyco_trans_28_C. [Graphical view]
Pfam	PF04101. Glyco_tran_28_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALG13_KLULA

Accession

Primary (citable) accession number: Q6CXY0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	August 16, 2004
Last modified:	November 3, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)