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Q6CXW4

- GCN5_KLULA

UniProt

Q6CXW4 - GCN5_KLULA

Protein

Histone acetyltransferase GCN5

Gene

GCN5

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K14ac, with a lower preference histone H4 to form H4K8ac and H4K16ac, and contributes to H2A.Z acetylation. Acetylation of histones gives a specific tag for epigenetic transcription activation By similarity.By similarity

    Catalytic activityi

    Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei250 – 2501Important for catalytic activityBy similarity

    GO - Molecular functioni

    1. histone acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Acyltransferase, Chromatin regulator, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone acetyltransferase GCN5 (EC:2.3.1.48)
    Gene namesi
    Name:GCN5
    Ordered Locus Names:KLLA0A05115g
    OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
    Taxonomic identifieri284590 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
    ProteomesiUP000000598: Chromosome A

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 516516Histone acetyltransferase GCN5PRO_0000211198Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi28985.Q6CXW4.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6CXW4.
    SMRiQ6CXW4. Positions 176-339, 406-515.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini177 – 332156N-acetyltransferasePROSITE-ProRule annotationAdd
    BLAST
    Domaini421 – 49171BromoPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 bromo domain.PROSITE-ProRule annotation
    Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Bromodomain

    Phylogenomic databases

    eggNOGiCOG5076.
    HOGENOMiHOG000192257.
    KOiK06062.
    OMAiDNCRKYN.
    OrthoDBiEOG7XM37B.

    Family and domain databases

    Gene3Di1.20.920.10. 1 hit.
    3.40.630.30. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR001487. Bromodomain.
    IPR018359. Bromodomain_CS.
    IPR000182. GNAT_dom.
    [Graphical view]
    PfamiPF13508. Acetyltransf_7. 1 hit.
    PF00439. Bromodomain. 1 hit.
    [Graphical view]
    PRINTSiPR00503. BROMODOMAIN.
    SMARTiSM00297. BROMO. 1 hit.
    [Graphical view]
    SUPFAMiSSF47370. SSF47370. 1 hit.
    SSF55729. SSF55729. 1 hit.
    PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
    PS50014. BROMODOMAIN_2. 1 hit.
    PS51186. GNAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6CXW4-1 [UniParc]FASTAAdd to Basket

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    MPPKRRHHGA GRVQNKRGKV DTVKEEIKPK DEPVETEIDG GSAVDEDVTD    50
    DLEHKTSKED QKEDQKEEDG PIDAQNGTSE TKVAGESVKT VEDKIESVTT 100
    NEEVVESPVN DYNASSTTTK AEEKQLEEEA NEKTDTSPIV ENEVVDEEAG 150
    TTKFDFDGQE YSYKDRPSVI EEKEGKIEFR VVNNDNSKEN MMVLTGLKNI 200
    FQKQLPKMPK EYIARLVYDR SHLSMAVVRK PLTVVGGITY RPFDKREFAE 250
    IVFCAISSTE QVRGYGAHLM NHLKDYVRAT SPIKYFLTYA DNYAIGYFKK 300
    QGFTKEITLD KNVWMGYIKD YEGGTLMQCS MLPRIRYLDA AKILLLQEAA 350
    IRRKIRSISQ SHIVRPGLKQ FLDLDNIKPI DPMTIPGLKE AGWTPEMDEL 400
    AQRPKRGPHY AAMQNLLTEL QNHAAAWPFL QPVNKEEVPD YYEFIKEPMD 450
    LSSMEMKLNG NRYEKMENFI YDARLIFNNC RAYNGENTSY FKYANRLEKF 500
    FNSKVKEIPE YSHLVD 516
    Length:516
    Mass (Da):59,291
    Last modified:August 16, 2004 - v1
    Checksum:iF11C13FA976421F0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382121 Genomic DNA. Translation: CAH02813.1.
    RefSeqiXP_451225.1. XM_451225.1.

    Genome annotation databases

    GeneIDi2896739.
    KEGGikla:KLLA0A05115g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382121 Genomic DNA. Translation: CAH02813.1 .
    RefSeqi XP_451225.1. XM_451225.1.

    3D structure databases

    ProteinModelPortali Q6CXW4.
    SMRi Q6CXW4. Positions 176-339, 406-515.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 28985.Q6CXW4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2896739.
    KEGGi kla:KLLA0A05115g.

    Phylogenomic databases

    eggNOGi COG5076.
    HOGENOMi HOG000192257.
    KOi K06062.
    OMAi DNCRKYN.
    OrthoDBi EOG7XM37B.

    Family and domain databases

    Gene3Di 1.20.920.10. 1 hit.
    3.40.630.30. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR001487. Bromodomain.
    IPR018359. Bromodomain_CS.
    IPR000182. GNAT_dom.
    [Graphical view ]
    Pfami PF13508. Acetyltransf_7. 1 hit.
    PF00439. Bromodomain. 1 hit.
    [Graphical view ]
    PRINTSi PR00503. BROMODOMAIN.
    SMARTi SM00297. BROMO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47370. SSF47370. 1 hit.
    SSF55729. SSF55729. 1 hit.
    PROSITEi PS00633. BROMODOMAIN_1. 1 hit.
    PS50014. BROMODOMAIN_2. 1 hit.
    PS51186. GNAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiGCN5_KLULA
    AccessioniPrimary (citable) accession number: Q6CXW4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3