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Q6CXW4

- GCN5_KLULA

UniProt

Q6CXW4 - GCN5_KLULA

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Protein

Histone acetyltransferase GCN5

Gene

GCN5

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K14ac, with a lower preference histone H4 to form H4K8ac and H4K16ac, and contributes to H2A.Z acetylation. Acetylation of histones gives a specific tag for epigenetic transcription activation (By similarity).By similarity

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei250 – 2501Proton donor/acceptorBy similarity
Sitei250 – 2501Important for catalytic activityBy similarity

GO - Molecular functioni

  1. histone acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase GCN5 (EC:2.3.1.48)
Gene namesi
Name:GCN5
Ordered Locus Names:KLLA0A05115g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
ProteomesiUP000000598: Chromosome A

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 516516Histone acetyltransferase GCN5PRO_0000211198Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi28985.Q6CXW4.

Structurei

3D structure databases

ProteinModelPortaliQ6CXW4.
SMRiQ6CXW4. Positions 176-339, 406-515.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini177 – 332156N-acetyltransferasePROSITE-ProRule annotationAdd
BLAST
Domaini421 – 49171BromoPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni254 – 2563Acetyl-CoA bindingBy similarity
Regioni261 – 2677Acetyl-CoA bindingBy similarity
Regioni293 – 2964Acetyl-CoA bindingBy similarity

Sequence similaritiesi

Contains 1 bromo domain.PROSITE-ProRule annotation
Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Keywords - Domaini

Bromodomain

Phylogenomic databases

eggNOGiCOG5076.
HOGENOMiHOG000192257.
InParanoidiQ6CXW4.
KOiK06062.
OMAiDNCRKYN.
OrthoDBiEOG7XM37B.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF13508. Acetyltransf_7. 1 hit.
PF00439. Bromodomain. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF55729. SSF55729. 1 hit.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6CXW4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPPKRRHHGA GRVQNKRGKV DTVKEEIKPK DEPVETEIDG GSAVDEDVTD
60 70 80 90 100
DLEHKTSKED QKEDQKEEDG PIDAQNGTSE TKVAGESVKT VEDKIESVTT
110 120 130 140 150
NEEVVESPVN DYNASSTTTK AEEKQLEEEA NEKTDTSPIV ENEVVDEEAG
160 170 180 190 200
TTKFDFDGQE YSYKDRPSVI EEKEGKIEFR VVNNDNSKEN MMVLTGLKNI
210 220 230 240 250
FQKQLPKMPK EYIARLVYDR SHLSMAVVRK PLTVVGGITY RPFDKREFAE
260 270 280 290 300
IVFCAISSTE QVRGYGAHLM NHLKDYVRAT SPIKYFLTYA DNYAIGYFKK
310 320 330 340 350
QGFTKEITLD KNVWMGYIKD YEGGTLMQCS MLPRIRYLDA AKILLLQEAA
360 370 380 390 400
IRRKIRSISQ SHIVRPGLKQ FLDLDNIKPI DPMTIPGLKE AGWTPEMDEL
410 420 430 440 450
AQRPKRGPHY AAMQNLLTEL QNHAAAWPFL QPVNKEEVPD YYEFIKEPMD
460 470 480 490 500
LSSMEMKLNG NRYEKMENFI YDARLIFNNC RAYNGENTSY FKYANRLEKF
510
FNSKVKEIPE YSHLVD
Length:516
Mass (Da):59,291
Last modified:August 16, 2004 - v1
Checksum:iF11C13FA976421F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382121 Genomic DNA. Translation: CAH02813.1.
RefSeqiXP_451225.1. XM_451225.1.

Genome annotation databases

GeneIDi2896739.
KEGGikla:KLLA0A05115g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382121 Genomic DNA. Translation: CAH02813.1 .
RefSeqi XP_451225.1. XM_451225.1.

3D structure databases

ProteinModelPortali Q6CXW4.
SMRi Q6CXW4. Positions 176-339, 406-515.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 28985.Q6CXW4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2896739.
KEGGi kla:KLLA0A05115g.

Phylogenomic databases

eggNOGi COG5076.
HOGENOMi HOG000192257.
InParanoidi Q6CXW4.
KOi K06062.
OMAi DNCRKYN.
OrthoDBi EOG7XM37B.

Family and domain databases

Gene3Di 1.20.920.10. 1 hit.
3.40.630.30. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR000182. GNAT_dom.
[Graphical view ]
Pfami PF13508. Acetyltransf_7. 1 hit.
PF00439. Bromodomain. 1 hit.
[Graphical view ]
PRINTSi PR00503. BROMODOMAIN.
SMARTi SM00297. BROMO. 1 hit.
[Graphical view ]
SUPFAMi SSF47370. SSF47370. 1 hit.
SSF55729. SSF55729. 1 hit.
PROSITEi PS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51186. GNAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiGCN5_KLULA
AccessioniPrimary (citable) accession number: Q6CXW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: August 16, 2004
Last modified: October 29, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3