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Protein

Histone-lysine N-methyltransferase, H3 lysine-36 specific

Gene

SET2

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Histone methyltransferase that methylates histone H3 to form H3K36me. Involved in transcription elongation as well as in transcription repression (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Repressor, Transferase
Biological processTranscription, Transcription regulation
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC:2.1.1.43)
Alternative name(s):
SET domain-containing protein 2
Gene namesi
Name:SET2
Ordered Locus Names:KLLA0A06600g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
Proteomesi
  • UP000000598 Componenti: Chromosome A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002697901 – 702Histone-lysine N-methyltransferase, H3 lysine-36 specificAdd BLAST702

Interactioni

Protein-protein interaction databases

STRINGi284590.XP_451294.1.

Structurei

3D structure databases

ProteinModelPortaliQ6CXP5.
SMRiQ6CXP5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 105AWSPROSITE-ProRule annotationAdd BLAST57
Domaini107 – 224SETPROSITE-ProRule annotationAdd BLAST118
Domaini231 – 247Post-SETPROSITE-ProRule annotationAdd BLAST17
Domaini445 – 477WWAdd BLAST33

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili554 – 611Sequence analysisAdd BLAST58

Domaini

The AWS and SET domains are necessary for transcription repression.By similarity

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4442. Eukaryota.
COG2940. LUCA.
HOGENOMiHOG000248214.
InParanoidiQ6CXP5.
KOiK11423.
OMAiYVDKWVV.
OrthoDBiEOG092C3T9B.

Family and domain databases

InterProiView protein in InterPro
IPR006560. AWS_dom.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
IPR036020. WW_dom_sf.
PfamiView protein in Pfam
PF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
SMARTiView protein in SMART
SM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiView protein in PROSITE
PS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6CXP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTESGNGIVN TRQPKLFLDV PDMTSEAKKT YAELDVCTYT PKNLGDSKHE
60 70 80 90 100
FMECDCFEEF RDGLNHACGE DSDCINRATL IECVNGLCKH SCGTDCQNQR
110 120 130 140 150
FQKKAYADIS VFKTERKGFG VRANSDIEPH NFIYEYIGEV IQEEEFRNRM
160 170 180 190 200
VKYDQMGFKH FYFMMLQTGQ FIDATLKGCI ARFCNHSCNP NAYVNKWVVN
210 220 230 240 250
GKLKMGIFAN RHISKGEEVT FDYNVDRYGA NAQPCYCEEP NCIGFLGGKT
260 270 280 290 300
QTDAASLLPQ SFADALGIRP SMEKKWINMM KAKGEKIAKS DTTTVNVDFV
310 320 330 340 350
NSLSLEPCTK TEDVNRVMSV LLQIDDAFIA EKLLERITLT EDEAMHYQFI
360 370 380 390 400
KLHGYLIFSR LITMFEDKPD IIWKILNFLL VLPKTTKNGI IHSGIDKKVE
410 420 430 440 450
QLKNTPKFEV ICEDLLEKWS KYETYTRISK KDISENSKVI DLRRIRLPIG
460 470 480 490 500
WEIIHENGRP VYYNAQRQIK QANPPTDSAY RSNSSHNLSG VSDPKSRSAT
510 520 530 540 550
PSSNTSRYSG SVKYIPTPTY GQMQQKRTLS PEEYEKRKKS RIEWEQKELE
560 570 580 590 600
LRKLMEQETL KAKLDQETQK KSELERIIEE ANKQKELERL QKLKQQQEDE
610 620 630 640 650
ERKKVKKQAS HVNAIENKWV KFFAQHVPNL IKNYQKDVGK DVLKESARNI
660 670 680 690 700
VKSLAQKELK KDSSRSPPEE LSKEKRAKVK TFSMQYMDRL VAKMKEKKEK

KR
Length:702
Mass (Da):81,294
Last modified:August 16, 2004 - v1
Checksum:i565F6D044530BB29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382121 Genomic DNA. Translation: CAH02882.1.
RefSeqiXP_451294.1. XM_451294.1.

Genome annotation databases

EnsemblFungiiCAH02882; CAH02882; KLLA0_A06600g.
GeneIDi2896759.
KEGGikla:KLLA0A06600g.

Similar proteinsi

Entry informationi

Entry nameiSET2_KLULA
AccessioniPrimary (citable) accession number: Q6CXP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: August 16, 2004
Last modified: October 25, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families