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Q6CXP5

- SET2_KLULA

UniProt

Q6CXP5 - SET2_KLULA

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Protein
Histone-lysine N-methyltransferase, H3 lysine-36 specific
Gene
SET2, KLLA0A06600g
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Histone methyltransferase that methylates histone H3 to form H3K36me. Involved in transcription elongation as well as in transcription repression By similarity.

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

GO - Molecular functioni

  1. histone methyltransferase activity (H3-K36 specific) Source: InterPro

GO - Biological processi

  1. DNA-templated transcription, elongation Source: InterPro
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Repressor, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC:2.1.1.43)
Alternative name(s):
SET domain-containing protein 2
Gene namesi
Name:SET2
Ordered Locus Names:KLLA0A06600g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
ProteomesiUP000000598: Chromosome A

Subcellular locationi

Nucleus By similarity. Chromosome By similarity

GO - Cellular componenti

  1. chromosome Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 702702Histone-lysine N-methyltransferase, H3 lysine-36 specific
PRO_0000269790Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi28985.Q6CXP5.

Structurei

3D structure databases

ProteinModelPortaliQ6CXP5.
SMRiQ6CXP5. Positions 450-475.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 10557AWS
Add
BLAST
Domaini107 – 224118SET
Add
BLAST
Domaini231 – 24717Post-SET
Add
BLAST
Domaini445 – 47733WW
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili554 – 61158 Reviewed prediction
Add
BLAST

Domaini

The AWS and SET domains are necessary for transcription repression By similarity.

Sequence similaritiesi

Contains 1 AWS domain.
Contains 1 post-SET domain.
Contains 1 SET domain.
Contains 1 WW domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG2940.
HOGENOMiHOG000248214.
KOiK11423.
OMAiSCNPNAY.
OrthoDBiEOG7P8PH3.

Family and domain databases

InterProiIPR006560. AWS.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6CXP5-1 [UniParc]FASTAAdd to Basket

« Hide

MTESGNGIVN TRQPKLFLDV PDMTSEAKKT YAELDVCTYT PKNLGDSKHE    50
FMECDCFEEF RDGLNHACGE DSDCINRATL IECVNGLCKH SCGTDCQNQR 100
FQKKAYADIS VFKTERKGFG VRANSDIEPH NFIYEYIGEV IQEEEFRNRM 150
VKYDQMGFKH FYFMMLQTGQ FIDATLKGCI ARFCNHSCNP NAYVNKWVVN 200
GKLKMGIFAN RHISKGEEVT FDYNVDRYGA NAQPCYCEEP NCIGFLGGKT 250
QTDAASLLPQ SFADALGIRP SMEKKWINMM KAKGEKIAKS DTTTVNVDFV 300
NSLSLEPCTK TEDVNRVMSV LLQIDDAFIA EKLLERITLT EDEAMHYQFI 350
KLHGYLIFSR LITMFEDKPD IIWKILNFLL VLPKTTKNGI IHSGIDKKVE 400
QLKNTPKFEV ICEDLLEKWS KYETYTRISK KDISENSKVI DLRRIRLPIG 450
WEIIHENGRP VYYNAQRQIK QANPPTDSAY RSNSSHNLSG VSDPKSRSAT 500
PSSNTSRYSG SVKYIPTPTY GQMQQKRTLS PEEYEKRKKS RIEWEQKELE 550
LRKLMEQETL KAKLDQETQK KSELERIIEE ANKQKELERL QKLKQQQEDE 600
ERKKVKKQAS HVNAIENKWV KFFAQHVPNL IKNYQKDVGK DVLKESARNI 650
VKSLAQKELK KDSSRSPPEE LSKEKRAKVK TFSMQYMDRL VAKMKEKKEK 700
KR 702
Length:702
Mass (Da):81,294
Last modified:August 16, 2004 - v1
Checksum:i565F6D044530BB29
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382121 Genomic DNA. Translation: CAH02882.1.
RefSeqiXP_451294.1. XM_451294.1.

Genome annotation databases

GeneIDi2896759.
KEGGikla:KLLA0A06600g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382121 Genomic DNA. Translation: CAH02882.1 .
RefSeqi XP_451294.1. XM_451294.1.

3D structure databases

ProteinModelPortali Q6CXP5.
SMRi Q6CXP5. Positions 450-475.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 28985.Q6CXP5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2896759.
KEGGi kla:KLLA0A06600g.

Phylogenomic databases

eggNOGi COG2940.
HOGENOMi HOG000248214.
KOi K11423.
OMAi SCNPNAY.
OrthoDBi EOG7P8PH3.

Family and domain databases

InterProi IPR006560. AWS.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
IPR001202. WW_dom.
[Graphical view ]
Pfami PF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
[Graphical view ]
SMARTi SM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
SUPFAMi SSF51045. SSF51045. 1 hit.
PROSITEi PS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiSET2_KLULA
AccessioniPrimary (citable) accession number: Q6CXP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: August 16, 2004
Last modified: April 16, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi