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Q6CXP5

- SET2_KLULA

UniProt

Q6CXP5 - SET2_KLULA

Protein

Histone-lysine N-methyltransferase, H3 lysine-36 specific

Gene

SET2

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Histone methyltransferase that methylates histone H3 to form H3K36me. Involved in transcription elongation as well as in transcription repression By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].PROSITE-ProRule annotation

    GO - Molecular functioni

    1. histone methyltransferase activity (H3-K36 specific) Source: InterPro

    GO - Biological processi

    1. DNA-templated transcription, elongation Source: InterPro
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Repressor, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC:2.1.1.43)
    Alternative name(s):
    SET domain-containing protein 2
    Gene namesi
    Name:SET2
    Ordered Locus Names:KLLA0A06600g
    OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
    Taxonomic identifieri284590 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
    ProteomesiUP000000598: Chromosome A

    Subcellular locationi

    Nucleus By similarity. Chromosome By similarity

    GO - Cellular componenti

    1. chromosome Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Chromosome, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 702702Histone-lysine N-methyltransferase, H3 lysine-36 specificPRO_0000269790Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi28985.Q6CXP5.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6CXP5.
    SMRiQ6CXP5. Positions 450-475.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini49 – 10557AWSPROSITE-ProRule annotationAdd
    BLAST
    Domaini107 – 224118SETPROSITE-ProRule annotationAdd
    BLAST
    Domaini231 – 24717Post-SETPROSITE-ProRule annotationAdd
    BLAST
    Domaini445 – 47733WWAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili554 – 61158Sequence AnalysisAdd
    BLAST

    Domaini

    The AWS and SET domains are necessary for transcription repression.By similarity

    Sequence similaritiesi

    Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.PROSITE-ProRule annotation
    Contains 1 AWS domain.PROSITE-ProRule annotation
    Contains 1 post-SET domain.PROSITE-ProRule annotation
    Contains 1 SET domain.PROSITE-ProRule annotation
    Contains 1 WW domain.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG2940.
    HOGENOMiHOG000248214.
    KOiK11423.
    OMAiSCNPNAY.
    OrthoDBiEOG7P8PH3.

    Family and domain databases

    InterProiIPR006560. AWS.
    IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
    IPR003616. Post-SET_dom.
    IPR001214. SET_dom.
    IPR013257. SRI.
    IPR001202. WW_dom.
    [Graphical view]
    PfamiPF00856. SET. 1 hit.
    PF08236. SRI. 1 hit.
    [Graphical view]
    SMARTiSM00570. AWS. 1 hit.
    SM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view]
    SUPFAMiSSF51045. SSF51045. 1 hit.
    PROSITEiPS51215. AWS. 1 hit.
    PS50868. POST_SET. 1 hit.
    PS51568. SAM_MT43_SET2_1. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6CXP5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTESGNGIVN TRQPKLFLDV PDMTSEAKKT YAELDVCTYT PKNLGDSKHE    50
    FMECDCFEEF RDGLNHACGE DSDCINRATL IECVNGLCKH SCGTDCQNQR 100
    FQKKAYADIS VFKTERKGFG VRANSDIEPH NFIYEYIGEV IQEEEFRNRM 150
    VKYDQMGFKH FYFMMLQTGQ FIDATLKGCI ARFCNHSCNP NAYVNKWVVN 200
    GKLKMGIFAN RHISKGEEVT FDYNVDRYGA NAQPCYCEEP NCIGFLGGKT 250
    QTDAASLLPQ SFADALGIRP SMEKKWINMM KAKGEKIAKS DTTTVNVDFV 300
    NSLSLEPCTK TEDVNRVMSV LLQIDDAFIA EKLLERITLT EDEAMHYQFI 350
    KLHGYLIFSR LITMFEDKPD IIWKILNFLL VLPKTTKNGI IHSGIDKKVE 400
    QLKNTPKFEV ICEDLLEKWS KYETYTRISK KDISENSKVI DLRRIRLPIG 450
    WEIIHENGRP VYYNAQRQIK QANPPTDSAY RSNSSHNLSG VSDPKSRSAT 500
    PSSNTSRYSG SVKYIPTPTY GQMQQKRTLS PEEYEKRKKS RIEWEQKELE 550
    LRKLMEQETL KAKLDQETQK KSELERIIEE ANKQKELERL QKLKQQQEDE 600
    ERKKVKKQAS HVNAIENKWV KFFAQHVPNL IKNYQKDVGK DVLKESARNI 650
    VKSLAQKELK KDSSRSPPEE LSKEKRAKVK TFSMQYMDRL VAKMKEKKEK 700
    KR 702
    Length:702
    Mass (Da):81,294
    Last modified:August 16, 2004 - v1
    Checksum:i565F6D044530BB29
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382121 Genomic DNA. Translation: CAH02882.1.
    RefSeqiXP_451294.1. XM_451294.1.

    Genome annotation databases

    GeneIDi2896759.
    KEGGikla:KLLA0A06600g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382121 Genomic DNA. Translation: CAH02882.1 .
    RefSeqi XP_451294.1. XM_451294.1.

    3D structure databases

    ProteinModelPortali Q6CXP5.
    SMRi Q6CXP5. Positions 450-475.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 28985.Q6CXP5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2896759.
    KEGGi kla:KLLA0A06600g.

    Phylogenomic databases

    eggNOGi COG2940.
    HOGENOMi HOG000248214.
    KOi K11423.
    OMAi SCNPNAY.
    OrthoDBi EOG7P8PH3.

    Family and domain databases

    InterProi IPR006560. AWS.
    IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
    IPR003616. Post-SET_dom.
    IPR001214. SET_dom.
    IPR013257. SRI.
    IPR001202. WW_dom.
    [Graphical view ]
    Pfami PF00856. SET. 1 hit.
    PF08236. SRI. 1 hit.
    [Graphical view ]
    SMARTi SM00570. AWS. 1 hit.
    SM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51045. SSF51045. 1 hit.
    PROSITEi PS51215. AWS. 1 hit.
    PS50868. POST_SET. 1 hit.
    PS51568. SAM_MT43_SET2_1. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiSET2_KLULA
    AccessioniPrimary (citable) accession number: Q6CXP5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3