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Q6CXP5 (SET2_KLULA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase, H3 lysine-36 specific
EC=2.1.1.43
Alternative name(s):
SET domain-containing protein 2
Gene names
Name:SET2
Ordered Locus Names:KLLA0A06600g
OrganismKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]
Taxonomic identifier284590 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces ›

Protein attributes

Sequence length702 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Histone methyltransferase that methylates histone H3 to form H3K36me. Involved in transcription elongation as well as in transcription repression By similarity.

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Subcellular location

Nucleus By similarity. Chromosome By similarity.

Domain

The AWS and SET domains are necessary for transcription repression By similarity.

Sequence similarities

Belongs to the histone-lysine methyltransferase family. SET2 subfamily.

Contains 1 AWS domain.

Contains 1 post-SET domain.

Contains 1 SET domain.

Contains 1 WW domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentChromosome
Nucleus
   DomainCoiled coil
   Molecular functionMethyltransferase
Repressor
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processDNA-dependent transcription, elongation

Inferred from electronic annotation. Source: InterPro

regulation of transcription, DNA-dependent

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentchromosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionhistone methyltransferase activity (H3-K36 specific)

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 702702Histone-lysine N-methyltransferase, H3 lysine-36 specific
PRO_0000269790

Regions

Domain49 – 10557AWS
Domain106 – 228123SET
Domain231 – 24717Post-SET
Domain445 – 47733WW
Coiled coil554 – 61158 Potential

Sequences

Sequence LengthMass (Da)Tools
Q6CXP5 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 565F6D044530BB29

FASTA70281,294
        10         20         30         40         50         60 
MTESGNGIVN TRQPKLFLDV PDMTSEAKKT YAELDVCTYT PKNLGDSKHE FMECDCFEEF 

        70         80         90        100        110        120 
RDGLNHACGE DSDCINRATL IECVNGLCKH SCGTDCQNQR FQKKAYADIS VFKTERKGFG 

       130        140        150        160        170        180 
VRANSDIEPH NFIYEYIGEV IQEEEFRNRM VKYDQMGFKH FYFMMLQTGQ FIDATLKGCI 

       190        200        210        220        230        240 
ARFCNHSCNP NAYVNKWVVN GKLKMGIFAN RHISKGEEVT FDYNVDRYGA NAQPCYCEEP 

       250        260        270        280        290        300 
NCIGFLGGKT QTDAASLLPQ SFADALGIRP SMEKKWINMM KAKGEKIAKS DTTTVNVDFV 

       310        320        330        340        350        360 
NSLSLEPCTK TEDVNRVMSV LLQIDDAFIA EKLLERITLT EDEAMHYQFI KLHGYLIFSR 

       370        380        390        400        410        420 
LITMFEDKPD IIWKILNFLL VLPKTTKNGI IHSGIDKKVE QLKNTPKFEV ICEDLLEKWS 

       430        440        450        460        470        480 
KYETYTRISK KDISENSKVI DLRRIRLPIG WEIIHENGRP VYYNAQRQIK QANPPTDSAY 

       490        500        510        520        530        540 
RSNSSHNLSG VSDPKSRSAT PSSNTSRYSG SVKYIPTPTY GQMQQKRTLS PEEYEKRKKS 

       550        560        570        580        590        600 
RIEWEQKELE LRKLMEQETL KAKLDQETQK KSELERIIEE ANKQKELERL QKLKQQQEDE 

       610        620        630        640        650        660 
ERKKVKKQAS HVNAIENKWV KFFAQHVPNL IKNYQKDVGK DVLKESARNI VKSLAQKELK 

       670        680        690        700 
KDSSRSPPEE LSKEKRAKVK TFSMQYMDRL VAKMKEKKEK KR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR382121 Genomic DNA. Translation: CAH02882.1.
RefSeqXP_451294.1. XM_451294.1.

3D structure databases

HSSPHSSP built from PDB template 1E0N based on UniProtKB P46995.
ProteinModelPortalQ6CXP5.
SMRQ6CXP5. Positions 450-475.
ModBaseSearch...

Protein-protein interaction databases

STRING28985.Q6CXP5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2896759.
KEGGkla:KLLA0A06600g.

Phylogenomic databases

eggNOGCOG2940.
HOGENOMHOG000248214.
KOK11423.
OMAITFDYNV.
OrthoDBEOG40S3Q4.

Family and domain databases

InterProIPR006560. AWS.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
IPR001202. WW_dom.
[Graphical view]
PfamPF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
[Graphical view]
SMARTSM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMSSF51045. WW_Rsp5_WWP. 1 hit.
PROSITEPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
PS01159. WW_DOMAIN_1. False negative.
PS50020. WW_DOMAIN_2. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSET2_KLULA
AccessionPrimary (citable) accession number: Q6CXP5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: August 16, 2004
Last modified: May 1, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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