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Protein

Histone-lysine N-methyltransferase, H3 lysine-36 specific

Gene

SET2

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Histone methyltransferase that methylates histone H3 to form H3K36me. Involved in transcription elongation as well as in transcription repression (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].PROSITE-ProRule annotation

GO - Molecular functioni

  1. histone methyltransferase activity (H3-K36 specific) Source: InterPro

GO - Biological processi

  1. DNA-templated transcription, elongation Source: InterPro
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Repressor, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC:2.1.1.43)
Alternative name(s):
SET domain-containing protein 2
Gene namesi
Name:SET2
Ordered Locus Names:KLLA0A06600g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
ProteomesiUP000000598: Chromosome A

Subcellular locationi

Nucleus By similarity. Chromosome By similarity

GO - Cellular componenti

  1. chromosome Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 702702Histone-lysine N-methyltransferase, H3 lysine-36 specificPRO_0000269790Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi28985.Q6CXP5.

Structurei

3D structure databases

ProteinModelPortaliQ6CXP5.
SMRiQ6CXP5. Positions 450-475.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 10557AWSPROSITE-ProRule annotationAdd
BLAST
Domaini107 – 224118SETPROSITE-ProRule annotationAdd
BLAST
Domaini231 – 24717Post-SETPROSITE-ProRule annotationAdd
BLAST
Domaini445 – 47733WWAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili554 – 61158Sequence AnalysisAdd
BLAST

Domaini

The AWS and SET domains are necessary for transcription repression.By similarity

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.PROSITE-ProRule annotation
Contains 1 AWS domain.PROSITE-ProRule annotation
Contains 1 post-SET domain.PROSITE-ProRule annotation
Contains 1 SET domain.PROSITE-ProRule annotation
Contains 1 WW domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG2940.
HOGENOMiHOG000248214.
InParanoidiQ6CXP5.
KOiK11423.
OMAiFKHFYFM.
OrthoDBiEOG7P8PH3.

Family and domain databases

InterProiIPR006560. AWS_dom.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6CXP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTESGNGIVN TRQPKLFLDV PDMTSEAKKT YAELDVCTYT PKNLGDSKHE
60 70 80 90 100
FMECDCFEEF RDGLNHACGE DSDCINRATL IECVNGLCKH SCGTDCQNQR
110 120 130 140 150
FQKKAYADIS VFKTERKGFG VRANSDIEPH NFIYEYIGEV IQEEEFRNRM
160 170 180 190 200
VKYDQMGFKH FYFMMLQTGQ FIDATLKGCI ARFCNHSCNP NAYVNKWVVN
210 220 230 240 250
GKLKMGIFAN RHISKGEEVT FDYNVDRYGA NAQPCYCEEP NCIGFLGGKT
260 270 280 290 300
QTDAASLLPQ SFADALGIRP SMEKKWINMM KAKGEKIAKS DTTTVNVDFV
310 320 330 340 350
NSLSLEPCTK TEDVNRVMSV LLQIDDAFIA EKLLERITLT EDEAMHYQFI
360 370 380 390 400
KLHGYLIFSR LITMFEDKPD IIWKILNFLL VLPKTTKNGI IHSGIDKKVE
410 420 430 440 450
QLKNTPKFEV ICEDLLEKWS KYETYTRISK KDISENSKVI DLRRIRLPIG
460 470 480 490 500
WEIIHENGRP VYYNAQRQIK QANPPTDSAY RSNSSHNLSG VSDPKSRSAT
510 520 530 540 550
PSSNTSRYSG SVKYIPTPTY GQMQQKRTLS PEEYEKRKKS RIEWEQKELE
560 570 580 590 600
LRKLMEQETL KAKLDQETQK KSELERIIEE ANKQKELERL QKLKQQQEDE
610 620 630 640 650
ERKKVKKQAS HVNAIENKWV KFFAQHVPNL IKNYQKDVGK DVLKESARNI
660 670 680 690 700
VKSLAQKELK KDSSRSPPEE LSKEKRAKVK TFSMQYMDRL VAKMKEKKEK

KR
Length:702
Mass (Da):81,294
Last modified:August 16, 2004 - v1
Checksum:i565F6D044530BB29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382121 Genomic DNA. Translation: CAH02882.1.
RefSeqiXP_451294.1. XM_451294.1.

Genome annotation databases

GeneIDi2896759.
KEGGikla:KLLA0A06600g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382121 Genomic DNA. Translation: CAH02882.1.
RefSeqiXP_451294.1. XM_451294.1.

3D structure databases

ProteinModelPortaliQ6CXP5.
SMRiQ6CXP5. Positions 450-475.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi28985.Q6CXP5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2896759.
KEGGikla:KLLA0A06600g.

Phylogenomic databases

eggNOGiCOG2940.
HOGENOMiHOG000248214.
InParanoidiQ6CXP5.
KOiK11423.
OMAiFKHFYFM.
OrthoDBiEOG7P8PH3.

Family and domain databases

InterProiIPR006560. AWS_dom.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSET2_KLULA
AccessioniPrimary (citable) accession number: Q6CXP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: August 16, 2004
Last modified: January 7, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.