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Q6CX23 (G3P2_KLULA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glyceraldehyde-3-phosphate dehydrogenase 2
Short name=GAPDH 2
EC=1.2.1.12
Gene names
Name:GAP2
Ordered Locus Names:KLLA0A11858g
OrganismKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]
Taxonomic identifier284590 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces

Protein attributes

Sequence length331 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH.

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionNAD binding

Inferred from electronic annotation. Source: InterPro

NADP binding

Inferred from electronic annotation. Source: InterPro

glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 331331Glyceraldehyde-3-phosphate dehydrogenase 2
PRO_0000145557

Regions

Nucleotide binding11 – 122NAD By similarity
Region148 – 1503Glyceraldehyde 3-phosphate binding By similarity
Region208 – 2092Glyceraldehyde 3-phosphate binding By similarity

Sites

Active site1491Nucleophile By similarity
Binding site331NAD By similarity
Binding site781NAD; via carbonyl oxygen By similarity
Binding site1791Glyceraldehyde 3-phosphate By similarity
Binding site2311Glyceraldehyde 3-phosphate By similarity
Binding site3131NAD By similarity
Site1761Activates thiol group during catalysis By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6CX23 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: E0E2A1400ECDF7A2

FASTA33135,546
        10         20         30         40         50         60 
MVRVAINGFG RIGRLVLRIA LSRPNVEVVA INDPFISVDY AAYMFKYDST HGRFAGEVSH 

        70         80         90        100        110        120 
DENSLIIDGK KVLVFQERDP ATLPWGEHNV DIAIDSTGVF KELDSAQKHI DAGAKKVVIT 

       130        140        150        160        170        180 
APSSTAPMFV VGVNEDKYNG ETIVSNASCT TNCLAPLAKV VNNAFGIEEG LMSTIHSITA 

       190        200        210        220        230        240 
TQKTVDGPSQ KDWRGGRTAS GNIIPSSTGA AKAVGKVLPE LQGKLTGMAF RVPTVDVSVV 

       250        260        270        280        290        300 
DLTVKLAKEA TYDEIKAVIK KASENELKGI LGYTEDAVVS SDFLGDTNSS IFDAAAGIQL 

       310        320        330 
SPKFVKLVTW YDNEYGYSTR VVDLVELVAK N

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR382121 Genomic DNA. Translation: CAH03104.1.
RefSeqXP_451516.1. XM_451516.1.

3D structure databases

ProteinModelPortalQ6CX23.
SMRQ6CX23. Positions 1-329.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ6CX23.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2896666.
GenomeReviewsGene locus KLLA0A11858g in contig CR382121_GR.
KEGGkla:KLLA0A11858g.

Phylogenomic databases

eggNOGfuNOG04196.
HOGENOMHBG571736.
OMAKFYTERD.
OrthoDBEOG4578GC.

Family and domain databases

InterProIPR020831. GlycerAld/Erythrose_P_DH.
IPR020830. GlycerAld_3-P_DH_AS.
IPR020829. GlycerAld_3-P_DH_cat.
IPR020828. GlycerAld_3-P_DH_NAD(P)-bd.
IPR006424. Glyceraldehyde-3-P_DH_1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00134.
PANTHERPTHR10836. GAP_DH. 1 hit.
PfamPF02800. Gp_dh_C. 1 hit.
PF00044. Gp_dh_N. 1 hit.
[Graphical view]
PIRSFPIRSF000149. GAP_DH. 1 hit.
PRINTSPR00078. G3PDHDRGNASE.
SMARTSM00846. Gp_dh_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01534. GAPDH-I. 1 hit.
PROSITEPS00071. GAPDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG3P2_KLULA
AccessionPrimary (citable) accession number: Q6CX23
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: August 16, 2004
Last modified: December 14, 2011
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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