Q6CWW0 (LCMT1_KLULA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Leucine carboxyl methyltransferase 1
EC=2.1.1.233

Alternative name(s):
Protein phosphatase methyltransferase 1
[Phosphatase 2A protein]-leucine-carboxy methyltransferase 1

Gene names

Name:	PPM1
Ordered Locus Names:	KLLA0B01089g

Organism

Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]

Taxonomic identifier

284590 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces › Kluyveromyces lactis

Protein attributes

Sequence length	333 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues By similarity.
Catalytic activity	S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine = S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester.
Sequence similarities	Belongs to the methyltransferase superfamily. LCMT family.

Ontologies

Keywords
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	methyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 333	333	Leucine carboxyl methyltransferase 1		PRO_0000226130
Regions
	Region	180 – 181	2	S-adenosyl-L-methionine binding By similarity
Sites
	Binding site	79	1	S-adenosyl-L-methionine By similarity
	Binding site	108	1	S-adenosyl-L-methionine; via carbonyl oxygen By similarity
	Binding site	131	1	S-adenosyl-L-methionine By similarity
	Binding site	206	1	S-adenosyl-L-methionine; via carbonyl oxygen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6CWW0 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: A84540C1046E764F	FASTA	333	38,811
	10 20 30 40 50 60 MERVIQETDN DAFSCKISAI TKRYLPSSEQ KKIGNYEHYE DIHLEFCKEI KSRSRRKYAN 70 80 90 100 110 120 ITKACRHSLP VMNYGTYLRT VSIDLKLTQW LKNNLENPAD KVQVINLGCG SDLRMMTFLA 130 140 150 160 170 180 SFPGVQWLDL DYKDVVTFKS TILRSNAKFR ASLQIEGDLP EEPSSIENVI TDRYQLLPCN 190 200 210 220 230 240 VTDDEQLIPI LKKYTDFSVP AVILTECVLC YLHESKASQL ISTVTGLYKQ GYWISYDPIG 250 260 270 280 290 300 GSQTNDRFGS IMQDNLMESR QLSMPTLMVF NSEDKYKERF PGKSEIQTMW DYYQNHLEDS 310 320 330 ERQRLKTLQF LDEIEELQVI FSHYVICTTN WRI

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR382122 Genomic DNA. Translation: CAH01972.1.
RefSeq	XP_451579.1. XM_451579.1.
3D structure databases
ProteinModelPortal	Q6CWW0.
ModBase	Search...
Protein-protein interaction databases
STRING	28985.Q6CWW0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2897248.
KEGG	kla:KLLA0B01089g.
Phylogenomic databases
eggNOG	NOG329644.
HOGENOM	HOG000113293.
OrthoDB	EOG4ZW8MC.
Family and domain databases
InterPro	IPR007213. LCM_MeTrfase. IPR021121. LCM_MeTrfase_euk. IPR016651. Leu_CO_MeTrfase_LCTM1. [Graphical view]
PANTHER	PTHR13600. PTHR13600. 1 hit.
Pfam	PF04072. LCM. 1 hit. [Graphical view]
PIRSF	PIRSF016305. LCM_mtfrase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LCMT1_KLULA

Accession

Primary (citable) accession number: Q6CWW0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	August 16, 2004
Last modified:	May 1, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program