Endopolyphosphatase - Kluyveromyces lactis (Yeast)

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Reviewed, UniProtKB/Swiss-Prot Q6CWT7 (PPN1_KLULA)

Last modified June 16, 2009. Version 31. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information

Names and origin

Protein names

Recommended name:
Endopolyphosphatase
EC=3.6.1.10

Gene names

Name:	PPN1
Ordered Locus Names:	KLLA0B01606g

Organism

Kluyveromyces lactis (Yeast) (Candida sphaerica) [Complete proteome]

Taxonomic identifier

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces

Protein attributes

Sequence length	681 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the hydrolysis of inorganic polyphosphate (poly P) chains of many hundreds of phosphate residues into shorter lengths By similarity.
Catalytic activity	Polyphosphate + n H₂O = (n+1) oligophosphate.
Subcellular location	Vacuole membrane; Single-pass type II membrane protein.
Post-translational modification	Processing by proteases in the vacuole may be required for activation By similarity.

Ontologies

Keywords
Cellular component	Membrane Vacuole
Domain	Signal-anchor Transmembrane
Molecular function	Hydrolase
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW vacuolar membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	endopolyphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

681

Endopolyphosphatase

PRO_0000058547

Regions

Topological domain

23

Cytoplasmic Potential

Transmembrane

21

Signal-anchor for type II membrane protein Potential

Topological domain

637

Vacuolar Potential

Compositional bias

14

Poly-Lys

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q6CWT7-1 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 329D965217E51EEF
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681

78,413

        10         20         30         40         50         60 
MKELQLPEKR KSNTGLSWFP SPRILQVFLV LLGAIVAFLS FSATSSIISS SPKHHSCHDN 

        70         80         90        100        110        120 
VEEAAVKYHY STISSDELPI SNERLASLGL TPNQPVKITD IGGKEKSIKG RFLHITDMHP 

       130        140        150        160        170        180 
DLYYKENTSI DDTCHRGKPK NDGDRAARFG NAMKGCDGPP DLMYYTLDWI HKNLSDEIDF 

       190        200        210        220        230        240 
IIWTGDNVRH DNDRRIPRTE QQIFDMNRQV SELFLKTFKD HESDDPRDLK VKIIPSLGNN 

       250        260        270        280        290        300 
DVFPHNLFSP GPTLQTRELY DIWSQFIPPA QQNTFDRYAS FFVEAIPGKL AVISLNTLYM 

       310        320        330        340        350        360 
FKGNPLVDNC SNKKQPGYKM LLWVGFTLQE LRDRGMKVWL SGHVPPIPKN FDSSCSDKLA 

       370        380        390        400        410        420 
LWLHEYSDII IGGFYGHMNM DHFIPVDGEK AWDDIANSMA ISEYSGFFEQ DFLEDAIAAR 

       430        440        450        460        470        480 
EIRAEGAKPV KKVNYMNGVR DAYYSRISED VKKLSEKDPL YERYSIVHIG TSIIPTFNPG 

       490        500        510        520        530        540 
FRIWEYNITE LQTEEEVLHS HQPWDSFFEH LDVEIQKIIE EAEEAEEVEA FEDDEQIDSE 

       550        560        570        580        590        600 
IPDVLISKKK KKKGKKGKKN KNSKNWWKTD KTFPKKKPKN LPPGPAYENQ LFSPLRFVQY 

       610        620        630        640        650        660 
YADLKEIDKQ YLKLLKEGKS EDEAASIAFK YQIEYASDDK PYPMKTTLVK DYIELASELS 

       670        680 
GNDKLWDTFL ERAFCSSGYE D

References

[1]

"Genome evolution in yeasts."
Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.

expand/collapse author list

Souciet J.-L.
Nature 430:35-44(2004) [PubMed: 15229592] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NRRL Y-1140 / WM37.

Cross-references

Sequence databases
	CR382122 Genomic DNA. Translation: CAH01995.1.
RefSeq	XP_451602.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2897267.
KEGG	kla:KLLA0B01606g.
Phylogenomic databases
HOGENOM	Q6CWT7.
OMA	Q6CWT7. GGLYGHM.
Enzyme and pathway databases
BRENDA	3.6.1.10. 74088.
Family and domain databases
InterPro	IPR012358. EndopolyPtase_N1. IPR004843. M-pesterase. [Graphical view]
PANTHER	PTHR10340:SF4. EndopolyPtase_N1. 1 hit.
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PIRSF	PIRSF027093. EndopolyPtase_N1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PPN1_KLULA

Accession

Primary (citable) accession number: Q6CWT7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2005
Last sequence update:	August 16, 2004
Last modified:	June 16, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information