Q6CWK9 (COX9_KLULA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 7A
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide VIIA

Gene names

Name:	COX9
Ordered Locus Names:	KLLA0B03289g

Organism

Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]

Taxonomic identifier

284590 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces › Kluyveromyces lactis

Protein attributes

Sequence length	60 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This small integral protein plays a role in holoenzyme assembly or stability By similarity.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Subunit structure	Composed of at least 11 subunits By similarity.
Subcellular location	Mitochondrion inner membrane By similarity.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	respiratory electron transport chain Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial respiratory chain Inferred from electronic annotation. Source: InterPro
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 57	56	Cytochrome c oxidase subunit 7A		PRO_0000041769
	Propeptide	58 – 60	3	Removed in mature form By similarity		PRO_0000041770
Regions
	Transmembrane	16 – 38	23	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6CWK9 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: A5D8097CD4F05D8B	FASTA	60	6,729
	10 20 30 40 50 60 MSAIAPITGT IRKRILADIT IGFAIGGAMA SYWWWGFHKN IINKREAYYA KLAEQKAAEN

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR382122 Genomic DNA. Translation: CAH02073.1.
RefSeq	XP_451680.1. XM_451680.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	28985.Q6CWK9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2897436.
KEGG	kla:KLLA0B03289g.
Phylogenomic databases
eggNOG	NOG82857.
HOGENOM	HOG000199609.
KO	K02269.
OMA	PITGTLK.
OrthoDB	EOG42NN97.
Family and domain databases
InterPro	IPR014368. Cyt_c_oxidase_su7a_fun. [Graphical view]
PIRSF	PIRSF000283. COX9. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COX9_KLULA

Accession

Primary (citable) accession number: Q6CWK9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2005
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 56 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program