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Q6CWJ6

- QCR2_KLULA

UniProt

Q6CWJ6 - QCR2_KLULA

Protein

Cytochrome b-c1 complex subunit 2, mitochondrial

Gene

QCR2

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex By similarity.By similarity

    GO - Molecular functioni

    1. catalytic activity Source: InterPro
    2. metal ion binding Source: InterPro

    GO - Biological processi

    1. oxidation-reduction process Source: UniProtKB-KW

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome b-c1 complex subunit 2, mitochondrial
    Alternative name(s):
    Complex III subunit 2
    Core protein II
    Ubiquinol-cytochrome-c reductase complex core protein 2
    Gene namesi
    Name:QCR2
    Ordered Locus Names:KLLA0B03564g
    OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
    Taxonomic identifieri284590 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
    ProteomesiUP000000598: Chromosome B

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB-SubCell
    2. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 1515MitochondrionBy similarityAdd
    BLAST
    Chaini16 – 360345Cytochrome b-c1 complex subunit 2, mitochondrialPRO_0000026797Add
    BLAST

    Interactioni

    Subunit structurei

    Fungi bc1 complex contains 10 subunits; 3 respiratory subunits, 2 core proteins and 5 low-molecular weight proteins.By similarity

    Protein-protein interaction databases

    STRINGi28985.Q6CWJ6.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6CWJ6.
    SMRiQ6CWJ6. Positions 16-360.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0612.
    HOGENOMiHOG000159494.
    KOiK00415.
    OMAiYITLKAT.
    OrthoDBiEOG7F51BJ.

    Family and domain databases

    Gene3Di3.30.830.10. 2 hits.
    InterProiIPR011249. Metalloenz_LuxS/M16.
    IPR011237. Pept_M16_dom.
    IPR011765. Pept_M16_N.
    IPR007863. Peptidase_M16_C.
    [Graphical view]
    PfamiPF00675. Peptidase_M16. 1 hit.
    PF05193. Peptidase_M16_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF63411. SSF63411. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6CWJ6-1 [UniParc]FASTAAdd to Basket

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    MLSSRLQFAQ QTARKFSISA KDGSGKLSTL AVKVHGGSRY ADKEGIAHLL    50
    SRFNFHNTGN KSALRLVRES ELLGGKFESS VDREYITLKA TFLKEDLPYF 100
    VNALGNVLYK TSFRPHELPE SVLPAAKYDI SVSETNPINK AEDLLYNVSF 150
    RKDLGNTVLY RGVEKVTLDD IKAYANKVYT KENIEIVGQG VNEADLKRFV 200
    NDSLIGSLPT GSKLAAQAQP KFFSGEARLS APGASVAAIA VPVTKEQFAT 250
    YEVLAKYLTS ALSELSPLID SAKLDKYANA GLFSLYVKGE DASVVAENIK 300
    KVVDTLKKDV DISAAKEYTA LQLSLENAPI DVSNVKNVKL DKFSYAAVGN 350
    VAKLPFADEL 360
    Length:360
    Mass (Da):39,248
    Last modified:August 16, 2004 - v1
    Checksum:i0E5B9D6D6AB18A4A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382122 Genomic DNA. Translation: CAH02086.1.
    RefSeqiXP_451693.1. XM_451693.1.

    Genome annotation databases

    GeneIDi2897081.
    KEGGikla:KLLA0B03564g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382122 Genomic DNA. Translation: CAH02086.1 .
    RefSeqi XP_451693.1. XM_451693.1.

    3D structure databases

    ProteinModelPortali Q6CWJ6.
    SMRi Q6CWJ6. Positions 16-360.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 28985.Q6CWJ6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2897081.
    KEGGi kla:KLLA0B03564g.

    Phylogenomic databases

    eggNOGi COG0612.
    HOGENOMi HOG000159494.
    KOi K00415.
    OMAi YITLKAT.
    OrthoDBi EOG7F51BJ.

    Family and domain databases

    Gene3Di 3.30.830.10. 2 hits.
    InterProi IPR011249. Metalloenz_LuxS/M16.
    IPR011237. Pept_M16_dom.
    IPR011765. Pept_M16_N.
    IPR007863. Peptidase_M16_C.
    [Graphical view ]
    Pfami PF00675. Peptidase_M16. 1 hit.
    PF05193. Peptidase_M16_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF63411. SSF63411. 2 hits.
    ProtoNeti Search...

    Entry informationi

    Entry nameiQCR2_KLULA
    AccessioniPrimary (citable) accession number: Q6CWJ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Caution

    Does not seem to have a protease activity as it lack the zinc-binding site.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3