Q6CWJ6 (QCR2_KLULA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome b-c1 complex subunit 2, mitochondrial

Alternative name(s):
Complex III subunit 2
Core protein II
Ubiquinol-cytochrome-c reductase complex core protein 2

Gene names

Name:	QCR2
Ordered Locus Names:	KLLA0B03564g

Organism

Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]

Taxonomic identifier

284590 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces › Kluyveromyces lactis

Protein attributes

Sequence length	360 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex By similarity.
Subunit structure	Fungi bc1 complex contains 10 subunits; 3 respiratory subunits, 2 core proteins and 5 low-molecular weight proteins By similarity.
Subcellular location	Mitochondrion inner membrane By similarity.
Sequence similarities	Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily.
Caution	Does not seem to have a protease activity as it lack the zinc-binding site.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	catalytic activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 15	15	Mitochondrion By similarity
	Chain	16 – 360	345	Cytochrome b-c1 complex subunit 2, mitochondrial		PRO_0000026797

Sequences

	Sequence		Length	Mass (Da)
	Q6CWJ6 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 0E5B9D6D6AB18A4A	FASTA	360	39,248
	10 20 30 40 50 60 MLSSRLQFAQ QTARKFSISA KDGSGKLSTL AVKVHGGSRY ADKEGIAHLL SRFNFHNTGN 70 80 90 100 110 120 KSALRLVRES ELLGGKFESS VDREYITLKA TFLKEDLPYF VNALGNVLYK TSFRPHELPE 130 140 150 160 170 180 SVLPAAKYDI SVSETNPINK AEDLLYNVSF RKDLGNTVLY RGVEKVTLDD IKAYANKVYT 190 200 210 220 230 240 KENIEIVGQG VNEADLKRFV NDSLIGSLPT GSKLAAQAQP KFFSGEARLS APGASVAAIA 250 260 270 280 290 300 VPVTKEQFAT YEVLAKYLTS ALSELSPLID SAKLDKYANA GLFSLYVKGE DASVVAENIK 310 320 330 340 350 360 KVVDTLKKDV DISAAKEYTA LQLSLENAPI DVSNVKNVKL DKFSYAAVGN VAKLPFADEL

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR382122 Genomic DNA. Translation: CAH02086.1.
RefSeq	XP_451693.1. XM_451693.1.
3D structure databases
ProteinModelPortal	Q6CWJ6.
SMR	Q6CWJ6. Positions 16-360.
ModBase	Search...
Protein-protein interaction databases
STRING	28985.Q6CWJ6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2897081.
KEGG	kla:KLLA0B03564g.
Phylogenomic databases
eggNOG	COG0612.
HOGENOM	HOG000159494.
KO	K00415.
OMA	YITLKAT.
OrthoDB	EOG4Q2HPZ.
Family and domain databases
Gene3D	3.30.830.10. 2 hits.
InterPro	IPR011249. Metalloenz_LuxS/M16. IPR011237. Pept_M16_dom. IPR011765. Pept_M16_N. IPR007863. Peptidase_M16_C. [Graphical view]
Pfam	PF00675. Peptidase_M16. 1 hit. PF05193. Peptidase_M16_C. 1 hit. [Graphical view]
SUPFAM	SSF63411. Metalloenz_metal-bd. 2 hits.
ProtoNet	Search...

Entry information

Entry name

QCR2_KLULA

Accession

Primary (citable) accession number: Q6CWJ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	August 16, 2004
Last modified:	May 1, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program