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Protein

Cytochrome b-c1 complex subunit 2, mitochondrial

Gene

QCR2

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex (By similarity).By similarity

GO - Molecular functioni

  1. catalytic activity Source: InterPro
  2. metal ion binding Source: InterPro

GO - Biological processi

  1. oxidation-reduction process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 2, mitochondrial
Alternative name(s):
Complex III subunit 2
Core protein II
Ubiquinol-cytochrome-c reductase complex core protein 2
Gene namesi
Name:QCR2
Ordered Locus Names:KLLA0B03564g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
ProteomesiUP000000598 Componenti: Chromosome B

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB-SubCell
  2. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1515MitochondrionBy similarityAdd
BLAST
Chaini16 – 360345Cytochrome b-c1 complex subunit 2, mitochondrialPRO_0000026797Add
BLAST

Interactioni

Subunit structurei

Fungi bc1 complex contains 10 subunits; 3 respiratory subunits, 2 core proteins and 5 low-molecular weight proteins.By similarity

Protein-protein interaction databases

STRINGi28985.Q6CWJ6.

Structurei

3D structure databases

ProteinModelPortaliQ6CWJ6.
SMRiQ6CWJ6. Positions 16-360.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0612.
HOGENOMiHOG000159494.
InParanoidiQ6CWJ6.
KOiK00415.
OMAiYITLKAT.
OrthoDBiEOG7F51BJ.

Family and domain databases

Gene3Di3.30.830.10. 2 hits.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR011237. Pept_M16_dom.
IPR011765. Pept_M16_N.
IPR007863. Peptidase_M16_C.
[Graphical view]
PfamiPF00675. Peptidase_M16. 1 hit.
PF05193. Peptidase_M16_C. 1 hit.
[Graphical view]
SUPFAMiSSF63411. SSF63411. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6CWJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSSRLQFAQ QTARKFSISA KDGSGKLSTL AVKVHGGSRY ADKEGIAHLL
60 70 80 90 100
SRFNFHNTGN KSALRLVRES ELLGGKFESS VDREYITLKA TFLKEDLPYF
110 120 130 140 150
VNALGNVLYK TSFRPHELPE SVLPAAKYDI SVSETNPINK AEDLLYNVSF
160 170 180 190 200
RKDLGNTVLY RGVEKVTLDD IKAYANKVYT KENIEIVGQG VNEADLKRFV
210 220 230 240 250
NDSLIGSLPT GSKLAAQAQP KFFSGEARLS APGASVAAIA VPVTKEQFAT
260 270 280 290 300
YEVLAKYLTS ALSELSPLID SAKLDKYANA GLFSLYVKGE DASVVAENIK
310 320 330 340 350
KVVDTLKKDV DISAAKEYTA LQLSLENAPI DVSNVKNVKL DKFSYAAVGN
360
VAKLPFADEL
Length:360
Mass (Da):39,248
Last modified:August 16, 2004 - v1
Checksum:i0E5B9D6D6AB18A4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382122 Genomic DNA. Translation: CAH02086.1.
RefSeqiXP_451693.1. XM_451693.1.

Genome annotation databases

GeneIDi2897081.
KEGGikla:KLLA0B03564g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382122 Genomic DNA. Translation: CAH02086.1.
RefSeqiXP_451693.1. XM_451693.1.

3D structure databases

ProteinModelPortaliQ6CWJ6.
SMRiQ6CWJ6. Positions 16-360.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi28985.Q6CWJ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2897081.
KEGGikla:KLLA0B03564g.

Phylogenomic databases

eggNOGiCOG0612.
HOGENOMiHOG000159494.
InParanoidiQ6CWJ6.
KOiK00415.
OMAiYITLKAT.
OrthoDBiEOG7F51BJ.

Family and domain databases

Gene3Di3.30.830.10. 2 hits.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR011237. Pept_M16_dom.
IPR011765. Pept_M16_N.
IPR007863. Peptidase_M16_C.
[Graphical view]
PfamiPF00675. Peptidase_M16. 1 hit.
PF05193. Peptidase_M16_C. 1 hit.
[Graphical view]
SUPFAMiSSF63411. SSF63411. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiQCR2_KLULA
AccessioniPrimary (citable) accession number: Q6CWJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: August 16, 2004
Last modified: January 7, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Caution

Does not seem to have a protease activity as it lack the zinc-binding site.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.