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Q6CWC2

- NTE1_KLULA

UniProt

Q6CWC2 - NTE1_KLULA

Protein

Lysophospholipase NTE1

Gene

NTE1

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.By similarity

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

    Enzyme regulationi

    Inhibited by organophosphorus esters.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei1170 – 11701By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi592 – 718127cNMP 1Add
    BLAST
    Nucleotide bindingi707 – 836130cNMP 2Add
    BLAST

    GO - Molecular functioni

    1. lysophospholipase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid catabolic process Source: UniProtKB-KW
    2. phosphatidylcholine metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysophospholipase NTE1 (EC:3.1.1.5)
    Alternative name(s):
    Intracellular phospholipase B
    Neuropathy target esterase homolog
    Gene namesi
    Name:NTE1
    Ordered Locus Names:KLLA0B05225g
    OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
    Taxonomic identifieri284590 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
    ProteomesiUP000000598: Chromosome B

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14411441Lysophospholipase NTE1PRO_0000295322Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi28985.Q6CWC2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6CWC2.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2222LumenalBy similarityAdd
    BLAST
    Topological domaini44 – 14411398CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei23 – 4321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1137 – 1301165PatatinAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1168 – 11725GXSXG

    Sequence similaritiesi

    Belongs to the NTE family.Curated
    Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
    Contains 1 patatin domain.Curated

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0664.
    HOGENOMiHOG000048680.
    KOiK14676.
    OMAiASENDRS.
    OrthoDBiEOG70W3NS.

    Family and domain databases

    Gene3Di2.60.120.10. 4 hits.
    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 4 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6CWC2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWLTSYVLPR LKNILLLQFH ITLPLNYLVL LLLSTVIITY LFLRTRILSN     50
    YSQLKDDVSD ENNINRKDYM DASSASFLLN REKHKGFTSY LDEFLSAIKI 100
    FGYLEKPVFH ELTKSMKTEK LQEGEIVLLD DSVGFTIVVE GTLEILHKMD 150
    NRHSNPSGDA AANATAFEPP SNDDGYLING EKFQLLNIVK TGNPLSSLVS 200
    IMKLFSNRST HLNEGTHPST TNNTPGPGSP NLTGEINSFL DSTLPAKFGS 250
    ADSANGNHPI SPMELESTFD NLSEASENDR SAKIPDIIAR AASDCTIAII 300
    PSSSFQRLLV KYPRSASHII QMILTKLYRV TFKTAHTYLG LTNEIIFTEF 350
    QSINKDNLKL PEYFRRSIIS YFTNRQDDTG SSASTIQKRP QLHRRDSNNS 400
    LNYGSRHVVL NSRDQYNPGD LLSNVPLPRL NPQQRNDLSN TNSSSTLSRA 450
    DYRPIILNNF SSSQFEETEV SSWRLALVEI IFQQLGITKD TIEPPISDDF 500
    SLHDHSLDEK GLVRRSSYSS FTSLSSSIAT HSSNHLVTFL PRESQQFSRL 550
    NRTGGKMASH SKRLNGSSRS NSRTDRSESF DHFRNENLGG DNQFSDFESV 600
    KEDFSKCIKI LKFEEGETIL CQNSNPQGIY YLVSGEVDVI SETKDGNTDE 650
    SYERTLYTAT EGYILGYLSS ILGCKSLVTL KVSKGPAYLG LIPYNDLERL 700
    CDKYFMIYLK LSEILTNSLS PNLLRLDYFL EWIQLDSSET LFNQGDPANG 750
    VYLVLNGRLR QLFYEDADSD IVTQMAELSK GESFGEVEVL TAIHRLNTVV 800
    AIRDTELARI PRTLFEFLAV EHPSIMIHVS RMVAKKAMLM NFKSGIGFSG 850
    SQPITKLIGD ETAMQKRYDF NLNIKSNKSS KKNELISNTV NYKTLTLLPI 900
    TEGLPVEEFA YKLINALRQC GKTTIGLNQR TTLSHLGRHA FNKLSKLKQS 950
    GYFAELEELY EIVVYIADTP VSSSWTQTCI SQGDCILLLA DATCDPKIGE 1000
    FERLLLKSKT TARTDLILLH PERYVVPGST SKWLKNRMWI QSHHHIQFTP 1050
    MEKVAEPDPI PNIKPLSQLV EKFKENTKKT QENFVKFLPD SIKTTVETLS 1100
    GKYIDPKPNP KFYTSVDPIK NDFLRLARTL SGQAVGLVLG GGGARGLSHL 1150
    GIIKALEEQG IPIDIIGGTS IGSFVGGLYA MDYDLVPIYG RVKKFAGRVG 1200
    SLWRMLSDLT WPVTSYTTGH EFNRGIWKSF RDYRIEDFWI SYYCNSTNIT 1250
    ESVQEIHSSG FAWRYIRASM SLAGLLPPIV DNGNMLLDGG YVDNLPVTEM 1300
    TQRGCKIVFA VDVGSVDDRT PMSYGDSLNG FWIVLNRWNP FSKHPNIPNM 1350
    AEIQMRLGYV ASVNALERAK STPGVVYIRP PIENYATLDF GKFEEIYQVG 1400
    YAYGHDFLQH LQEKNELPPI AGTTTSAYAD KENMLQRRNS I 1441
    Length:1,441
    Mass (Da):162,157
    Last modified:August 16, 2004 - v1
    Checksum:iB882F8E0F9533C00
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382122 Genomic DNA. Translation: CAH02160.1.
    RefSeqiXP_451767.1. XM_451767.1.

    Genome annotation databases

    GeneIDi2896879.
    KEGGikla:KLLA0B05225g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382122 Genomic DNA. Translation: CAH02160.1 .
    RefSeqi XP_451767.1. XM_451767.1.

    3D structure databases

    ProteinModelPortali Q6CWC2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 28985.Q6CWC2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2896879.
    KEGGi kla:KLLA0B05225g.

    Phylogenomic databases

    eggNOGi COG0664.
    HOGENOMi HOG000048680.
    KOi K14676.
    OMAi ASENDRS.
    OrthoDBi EOG70W3NS.

    Family and domain databases

    Gene3Di 2.60.120.10. 4 hits.
    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 4 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiNTE1_KLULA
    AccessioniPrimary (citable) accession number: Q6CWC2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3