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Q6CWC2

- NTE1_KLULA

UniProt

Q6CWC2 - NTE1_KLULA

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Protein
Lysophospholipase NTE1
Gene
NTE1, KLLA0B05225g
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1170 – 11701 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi592 – 718127cNMP 1
Add
BLAST
Nucleotide bindingi707 – 836130cNMP 2
Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
  2. phosphatidylcholine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase NTE1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:NTE1
Ordered Locus Names:KLLA0B05225g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
ProteomesiUP000000598: Chromosome B

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222Lumenal By similarity
Add
BLAST
Transmembranei23 – 4321Helical; Reviewed prediction
Add
BLAST
Topological domaini44 – 14411398Cytoplasmic By similarity
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14411441Lysophospholipase NTE1
PRO_0000295322Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi28985.Q6CWC2.

Structurei

3D structure databases

ProteinModelPortaliQ6CWC2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1137 – 1301165Patatin
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1168 – 11725GXSXG

Sequence similaritiesi

Belongs to the NTE family.
Contains 1 patatin domain.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000048680.
KOiK14676.
OMAiASENDRS.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 4 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 4 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6CWC2-1 [UniParc]FASTAAdd to Basket

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MWLTSYVLPR LKNILLLQFH ITLPLNYLVL LLLSTVIITY LFLRTRILSN     50
YSQLKDDVSD ENNINRKDYM DASSASFLLN REKHKGFTSY LDEFLSAIKI 100
FGYLEKPVFH ELTKSMKTEK LQEGEIVLLD DSVGFTIVVE GTLEILHKMD 150
NRHSNPSGDA AANATAFEPP SNDDGYLING EKFQLLNIVK TGNPLSSLVS 200
IMKLFSNRST HLNEGTHPST TNNTPGPGSP NLTGEINSFL DSTLPAKFGS 250
ADSANGNHPI SPMELESTFD NLSEASENDR SAKIPDIIAR AASDCTIAII 300
PSSSFQRLLV KYPRSASHII QMILTKLYRV TFKTAHTYLG LTNEIIFTEF 350
QSINKDNLKL PEYFRRSIIS YFTNRQDDTG SSASTIQKRP QLHRRDSNNS 400
LNYGSRHVVL NSRDQYNPGD LLSNVPLPRL NPQQRNDLSN TNSSSTLSRA 450
DYRPIILNNF SSSQFEETEV SSWRLALVEI IFQQLGITKD TIEPPISDDF 500
SLHDHSLDEK GLVRRSSYSS FTSLSSSIAT HSSNHLVTFL PRESQQFSRL 550
NRTGGKMASH SKRLNGSSRS NSRTDRSESF DHFRNENLGG DNQFSDFESV 600
KEDFSKCIKI LKFEEGETIL CQNSNPQGIY YLVSGEVDVI SETKDGNTDE 650
SYERTLYTAT EGYILGYLSS ILGCKSLVTL KVSKGPAYLG LIPYNDLERL 700
CDKYFMIYLK LSEILTNSLS PNLLRLDYFL EWIQLDSSET LFNQGDPANG 750
VYLVLNGRLR QLFYEDADSD IVTQMAELSK GESFGEVEVL TAIHRLNTVV 800
AIRDTELARI PRTLFEFLAV EHPSIMIHVS RMVAKKAMLM NFKSGIGFSG 850
SQPITKLIGD ETAMQKRYDF NLNIKSNKSS KKNELISNTV NYKTLTLLPI 900
TEGLPVEEFA YKLINALRQC GKTTIGLNQR TTLSHLGRHA FNKLSKLKQS 950
GYFAELEELY EIVVYIADTP VSSSWTQTCI SQGDCILLLA DATCDPKIGE 1000
FERLLLKSKT TARTDLILLH PERYVVPGST SKWLKNRMWI QSHHHIQFTP 1050
MEKVAEPDPI PNIKPLSQLV EKFKENTKKT QENFVKFLPD SIKTTVETLS 1100
GKYIDPKPNP KFYTSVDPIK NDFLRLARTL SGQAVGLVLG GGGARGLSHL 1150
GIIKALEEQG IPIDIIGGTS IGSFVGGLYA MDYDLVPIYG RVKKFAGRVG 1200
SLWRMLSDLT WPVTSYTTGH EFNRGIWKSF RDYRIEDFWI SYYCNSTNIT 1250
ESVQEIHSSG FAWRYIRASM SLAGLLPPIV DNGNMLLDGG YVDNLPVTEM 1300
TQRGCKIVFA VDVGSVDDRT PMSYGDSLNG FWIVLNRWNP FSKHPNIPNM 1350
AEIQMRLGYV ASVNALERAK STPGVVYIRP PIENYATLDF GKFEEIYQVG 1400
YAYGHDFLQH LQEKNELPPI AGTTTSAYAD KENMLQRRNS I 1441
Length:1,441
Mass (Da):162,157
Last modified:August 16, 2004 - v1
Checksum:iB882F8E0F9533C00
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382122 Genomic DNA. Translation: CAH02160.1.
RefSeqiXP_451767.1. XM_451767.1.

Genome annotation databases

GeneIDi2896879.
KEGGikla:KLLA0B05225g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382122 Genomic DNA. Translation: CAH02160.1 .
RefSeqi XP_451767.1. XM_451767.1.

3D structure databases

ProteinModelPortali Q6CWC2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 28985.Q6CWC2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2896879.
KEGGi kla:KLLA0B05225g.

Phylogenomic databases

eggNOGi COG0664.
HOGENOMi HOG000048680.
KOi K14676.
OMAi ASENDRS.
OrthoDBi EOG70W3NS.

Family and domain databases

Gene3Di 2.60.120.10. 4 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 4 hits.
SSF52151. SSF52151. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiNTE1_KLULA
AccessioniPrimary (citable) accession number: Q6CWC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: August 16, 2004
Last modified: February 19, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3