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Q6CWC2 (NTE1_KLULA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysophospholipase NTE1

EC=3.1.1.5
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene names
Name:NTE1
Ordered Locus Names:KLLA0B05225g
OrganismKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]
Taxonomic identifier284590 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces

Protein attributes

Sequence length1441 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulation

Inhibited by organophosphorus esters By similarity.

Subcellular location

Endoplasmic reticulum membrane; Single-pass type I membrane protein Potential.

Sequence similarities

Belongs to the NTE family.

Contains 2 cyclic nucleotide-binding domains.

Contains 1 patatin domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 14411441Lysophospholipase NTE1
PRO_0000295322

Regions

Topological domain1 – 2222Lumenal By similarity
Transmembrane23 – 4321Helical; Potential
Topological domain44 – 14411398Cytoplasmic By similarity
Domain1137 – 1301165Patatin
Nucleotide binding592 – 718127cNMP 1
Nucleotide binding707 – 836130cNMP 2
Motif1168 – 11725GXSXG

Sites

Active site11701 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6CWC2 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: B882F8E0F9533C00

FASTA1,441162,157
        10         20         30         40         50         60 
MWLTSYVLPR LKNILLLQFH ITLPLNYLVL LLLSTVIITY LFLRTRILSN YSQLKDDVSD 

        70         80         90        100        110        120 
ENNINRKDYM DASSASFLLN REKHKGFTSY LDEFLSAIKI FGYLEKPVFH ELTKSMKTEK 

       130        140        150        160        170        180 
LQEGEIVLLD DSVGFTIVVE GTLEILHKMD NRHSNPSGDA AANATAFEPP SNDDGYLING 

       190        200        210        220        230        240 
EKFQLLNIVK TGNPLSSLVS IMKLFSNRST HLNEGTHPST TNNTPGPGSP NLTGEINSFL 

       250        260        270        280        290        300 
DSTLPAKFGS ADSANGNHPI SPMELESTFD NLSEASENDR SAKIPDIIAR AASDCTIAII 

       310        320        330        340        350        360 
PSSSFQRLLV KYPRSASHII QMILTKLYRV TFKTAHTYLG LTNEIIFTEF QSINKDNLKL 

       370        380        390        400        410        420 
PEYFRRSIIS YFTNRQDDTG SSASTIQKRP QLHRRDSNNS LNYGSRHVVL NSRDQYNPGD 

       430        440        450        460        470        480 
LLSNVPLPRL NPQQRNDLSN TNSSSTLSRA DYRPIILNNF SSSQFEETEV SSWRLALVEI 

       490        500        510        520        530        540 
IFQQLGITKD TIEPPISDDF SLHDHSLDEK GLVRRSSYSS FTSLSSSIAT HSSNHLVTFL 

       550        560        570        580        590        600 
PRESQQFSRL NRTGGKMASH SKRLNGSSRS NSRTDRSESF DHFRNENLGG DNQFSDFESV 

       610        620        630        640        650        660 
KEDFSKCIKI LKFEEGETIL CQNSNPQGIY YLVSGEVDVI SETKDGNTDE SYERTLYTAT 

       670        680        690        700        710        720 
EGYILGYLSS ILGCKSLVTL KVSKGPAYLG LIPYNDLERL CDKYFMIYLK LSEILTNSLS 

       730        740        750        760        770        780 
PNLLRLDYFL EWIQLDSSET LFNQGDPANG VYLVLNGRLR QLFYEDADSD IVTQMAELSK 

       790        800        810        820        830        840 
GESFGEVEVL TAIHRLNTVV AIRDTELARI PRTLFEFLAV EHPSIMIHVS RMVAKKAMLM 

       850        860        870        880        890        900 
NFKSGIGFSG SQPITKLIGD ETAMQKRYDF NLNIKSNKSS KKNELISNTV NYKTLTLLPI 

       910        920        930        940        950        960 
TEGLPVEEFA YKLINALRQC GKTTIGLNQR TTLSHLGRHA FNKLSKLKQS GYFAELEELY 

       970        980        990       1000       1010       1020 
EIVVYIADTP VSSSWTQTCI SQGDCILLLA DATCDPKIGE FERLLLKSKT TARTDLILLH 

      1030       1040       1050       1060       1070       1080 
PERYVVPGST SKWLKNRMWI QSHHHIQFTP MEKVAEPDPI PNIKPLSQLV EKFKENTKKT 

      1090       1100       1110       1120       1130       1140 
QENFVKFLPD SIKTTVETLS GKYIDPKPNP KFYTSVDPIK NDFLRLARTL SGQAVGLVLG 

      1150       1160       1170       1180       1190       1200 
GGGARGLSHL GIIKALEEQG IPIDIIGGTS IGSFVGGLYA MDYDLVPIYG RVKKFAGRVG 

      1210       1220       1230       1240       1250       1260 
SLWRMLSDLT WPVTSYTTGH EFNRGIWKSF RDYRIEDFWI SYYCNSTNIT ESVQEIHSSG 

      1270       1280       1290       1300       1310       1320 
FAWRYIRASM SLAGLLPPIV DNGNMLLDGG YVDNLPVTEM TQRGCKIVFA VDVGSVDDRT 

      1330       1340       1350       1360       1370       1380 
PMSYGDSLNG FWIVLNRWNP FSKHPNIPNM AEIQMRLGYV ASVNALERAK STPGVVYIRP 

      1390       1400       1410       1420       1430       1440 
PIENYATLDF GKFEEIYQVG YAYGHDFLQH LQEKNELPPI AGTTTSAYAD KENMLQRRNS 


I 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382122 Genomic DNA. Translation: CAH02160.1.
RefSeqXP_451767.1. XM_451767.1.

3D structure databases

ProteinModelPortalQ6CWC2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING28985.Q6CWC2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2896879.
KEGGkla:KLLA0B05225g.

Phylogenomic databases

eggNOGCOG0664.
HOGENOMHOG000048680.
KOK14676.
OMAASENDRS.
OrthoDBEOG70W3NS.

Family and domain databases

Gene3D2.60.120.10. 4 hits.
InterProIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMSSF51206. SSF51206. 4 hits.
SSF52151. SSF52151. 1 hit.
PROSITEPS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNTE1_KLULA
AccessionPrimary (citable) accession number: Q6CWC2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: August 16, 2004
Last modified: February 19, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families