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Reviewed, UniProtKB/Swiss-Prot Q6CW24 (CCPR_KLULA)

Last modified November 3, 2009. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Cytochrome c peroxidase, mitochondrial
      Short name=CCP
    EC=1.11.1.5
Gene names
Name: CCP1
Ordered Locus Names: KLLA0B07557g
OrganismKluyveromyces lactis (Yeast) (Candida sphaerica) [Complete proteome]
Taxonomic identifier28985 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces

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Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Destroys radicals which are normally produced within the cells and which are toxic to biological systems By similarity.

Catalytic activity

2 ferrocytochrome c + H2O2 = 2 ferricytochrome c + 2 H2O.

Cofactor

Binds 1 heme B (iron-protoporphyrin IX) group per subunit By similarity.

Subunit structure

Forms a one-to-one complex with cytochrome c By similarity.

Subcellular location

Mitochondrion matrix By similarity.

Sequence similarities

Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.

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Ontologies

Keywords
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandHeme
Iron
Metal-binding
   Molecular functionOxidoreductase
Peroxidase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

response to oxidative stress

Inferred from electronic annotation. Source: InterPro

   Cellular componentmitochondrial matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functioncytochrome-c peroxidase activity

Inferred from electronic annotation. Source: EC

heme binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 1212Mitochondrion
Chain13 – 346334Cytochrome c peroxidase, mitochondrial
PRO_0000045294

Sites

Active site1051Proton acceptor By similarity
Active site2441Tryptophan radical intermediate By similarity
Metal binding2281Iron (heme axial ligand)
Site1011Transition state stabilizer By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q6CW24-1 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 8E0797BBB40B9AFB

FASTA34639,041
        10         20         30         40         50         60 
MSTTFGNVFR RVNVKTLSFI VGAGALAGSA TGTVMEYQDM RNYNNRNYNK QKLAALAAAH 

        70         80         90        100        110        120 
VAAKEKYDVA KYQKVYNDIA LKIRDEDEYD DFIGYGPVLV RLAWHCAGTW DAKDNTGGPY 

       130        140        150        160        170        180 
GGTYRFAMET NDPSNNGLQN AAKFLEPIHE KYPWLSHGDL YSLAGVTAIQ EMQGPTIPWR 

       190        200        210        220        230        240 
SGRVDQPEDT TPENGRLPDA SKDAKYVRCF FHRLNFEDRQ VVALLGAHAL GKTHLKNSGF 

       250        260        270        280        290        300 
EGPWGAATNI FTNEFYNNLL NEKWDLITND AGNKQYVNDK GWMMLPTDMA LVQDPKYLPI 

       310        320        330        340 
VKEFANDQDT FFKEFTKAFV VLLENGIDFP QENKPIKFKT LDAQDL

« Hide

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Cross-references

Sequence databases

CR382122 Genomic DNA. Translation: CAH02258.1.
RefSeqXP_451865.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ6CW24.

Protein family/group databases

PeroxiBase2358. KlCcP01.

Genome annotation databases

GeneID2896897.
GenomeReviewsGene locus KLLA0B07557g in contig CR382122_GR.
KEGGkla:KLLA0B07557g.

Phylogenomic databases

HOGENOMQ6CW24.
OMAHALGKTH.

Enzyme and pathway databases

BRENDA1.11.1.5. 74088.

Family and domain databases

InterProIPR002207. Asc_perxdse.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamPF00141. peroxidase. 1 hit.
[Graphical view]
PRINTSPR00459. ASPEROXIDASE.
PR00458. PEROXIDASE.
PROSITEPS00435. PEROXIDASE_1. False negative.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameCCPR_KLULA
AccessionPrimary (citable) accession number: Q6CW24
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: August 16, 2004
Last modified: November 3, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents