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Q6CVF7

- PMIP_KLULA

UniProt

Q6CVF7 - PMIP_KLULA

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Protein
Mitochondrial intermediate peptidase
Gene
OCT1, KLLA0B12397g
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Binds 1 zinc ion By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi565 – 5651Zinc; catalytic By similarity
Active sitei566 – 5661 By similarity
Metal bindingi569 – 5691Zinc; catalytic By similarity
Metal bindingi572 – 5721Zinc; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM03.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
Ordered Locus Names:KLLA0B12397g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
ProteomesiUP000000598: Chromosome B

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2727Mitochondrion Reviewed prediction
Add
BLAST
Chaini28 – 779752Mitochondrial intermediate peptidase
PRO_0000338584Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi28985.Q6CVF7.

Structurei

3D structure databases

ProteinModelPortaliQ6CVF7.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0339.
HOGENOMiHOG000076521.
KOiK01410.
OMAiLQVFYSA.
OrthoDBiEOG71GB4R.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6CVF7-1 [UniParc]FASTAAdd to Basket

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MLRTVSVGRQ YVQRYFGHCL IVNSVRHSSS ATVNRLKQPL RRVFDDDSHW    50
RALNHSNYKL NESKGRKFGL RSTSDLETGL FQNSYLKSAN GLVEFTQHSF 100
EKAKELVQKI HSIETQDEMK YYIKDLDQLS DVLCRVIDLC EFIRATHPDK 150
KFVQTAQQCH EKMFEIMNIL NTDVRLCDLL TQCLRESDVL GLDSEEIRTG 200
KILLEDFEKS GIYMKPEIRE KFIQLSQEIS VIGQDFINNT EYVRSNYIKI 250
SCELMDAHVN KMVCSQMKKD ITGEYYKVPT YGYIPHTLLR TCSDEVIRMK 300
IWTEMHSCSD AQIERLTKLI SLRVELAKLL GSQNFAQYQL HGKMAKTPEN 350
VSGFLESLVH STRIKAASEL KPLAVLKSEL TGTQTPHTSE EVLELMKPWD 400
RDYYGSIQAL AQRRSSSLDN GESISSSFSL GVVMQGLSDL FEKIYGIKLV 450
PATPKTGETW SPDVRRIDVV DEHDGLIGVM YCDLFEREGK TPNPAHFTVC 500
CSRNMYLNEA DTSTIQVGVN SNGQKFQLPV ISLVCDFRWV EVNMGDGKHQ 550
QMCLLQLNEI ETLFHEMGHA MHSMLGRTQL QNVSGTRCAT DFVELPSILM 600
EHFARDTRVL SSISSHYKTG KSLDVEVLKN HQLENQFLQN CETFSQIKMS 650
FLDQELHNLD HTTDGSIDVI AIYHRLERRL AVLPDDQSNW CGKFGHLFGY 700
GASYYSYLFD RAIASKIWDH LFEQDPFNRT NGTKFKEGLL QWGGSRDPWY 750
LLSQVLDEPR LAKGDEWGMR YIGDVKTGM 779
Length:779
Mass (Da):89,380
Last modified:August 16, 2004 - v1
Checksum:iE25823250E5683BF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382122 Genomic DNA. Translation: CAH02475.1.
RefSeqiXP_452082.1. XM_452082.1.

Genome annotation databases

GeneIDi2897324.
KEGGikla:KLLA0B12397g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382122 Genomic DNA. Translation: CAH02475.1 .
RefSeqi XP_452082.1. XM_452082.1.

3D structure databases

ProteinModelPortali Q6CVF7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 28985.Q6CVF7.

Protein family/group databases

MEROPSi M03.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2897324.
KEGGi kla:KLLA0B12397g.

Phylogenomic databases

eggNOGi COG0339.
HOGENOMi HOG000076521.
KOi K01410.
OMAi LQVFYSA.
OrthoDBi EOG71GB4R.

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
3.40.390.10. 1 hit.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiPMIP_KLULA
AccessioniPrimary (citable) accession number: Q6CVF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: August 16, 2004
Last modified: May 14, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi