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Q6CV81

- DOHH_KLULA

UniProt

Q6CV81 - DOHH_KLULA

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Protein
Deoxyhypusine hydroxylase
Gene
LIA1, KLLA0B14080g
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor By similarity.UniRule annotation

Catalytic activityi

[eIF5A]-deoxyhypusine + AH2 + O2 = [eIF5A]-hypusine + A + H2O.UniRule annotation

Cofactori

Binds 2 Fe2+ ions per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi78 – 781Iron 1 By similarity
Metal bindingi79 – 791Iron 1 By similarity
Metal bindingi111 – 1111Iron 1 By similarity
Metal bindingi112 – 1121Iron 1 By similarity
Metal bindingi236 – 2361Iron 2 By similarity
Metal bindingi237 – 2371Iron 2 By similarity
Metal bindingi269 – 2691Iron 2 By similarity
Metal bindingi270 – 2701Iron 2 By similarity

GO - Molecular functioni

  1. deoxyhypusine monooxygenase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. peptidyl-lysine modification to peptidyl-hypusine Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Hypusine biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00354.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyhypusine hydroxylase (EC:1.14.99.29)
Short name:
DOHH
Alternative name(s):
Deoxyhypusine dioxygenase
Deoxyhypusine monooxygenase
Gene namesi
Name:LIA1
Ordered Locus Names:KLLA0B14080g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
ProteomesiUP000000598: Chromosome B

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322Deoxyhypusine hydroxylaseUniRule annotation
PRO_0000283667Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi28985.Q6CV81.

Structurei

3D structure databases

ProteinModelPortaliQ6CV81.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati76 – 10227HEAT-like PBS-type 1UniRule annotation
Add
BLAST
Repeati109 – 13527HEAT-like PBS-type 2UniRule annotation
Add
BLAST
Repeati267 – 29327HEAT-like PBS-type 3UniRule annotation
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1413.
HOGENOMiHOG000248665.
KOiK06072.
OMAiRESCQVA.
OrthoDBiEOG7QC85Z.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
HAMAPiMF_03101. Deoxyhypusine_hydroxylase.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR027517. Deoxyhypusine_hydroxylase.
IPR021133. HEAT_type_2.
IPR004155. PBS_lyase_HEAT.
[Graphical view]
SMARTiSM00567. EZ_HEAT. 5 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50077. HEAT_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6CV81-1 [UniParc]FASTAAdd to Basket

« Hide

MSTNFEKHFE VDVDNCSLEQ LRDILVNNSG KAPLANRFRA LFNLKGHAEE    50
FASKPEDALK ATQYLAEAFG DESELLKHEV AYVLGQTKNM AGAPLLRDVL 100
ADDKQQCMVR HEAAEALGAL NDVDSLDILE KYFKEDPLLE IRQTCELAID 150
RIKWETSEEG RREALQESLY SSIDPAPPFS LEKDYKIQEL KDILNDQNRP 200
LFERYRAMFR LRDIGNDEAC LALASGFDDP SALFKHEIAY VFGQICNPVV 250
VPHLKEVLAR PEEAPMVRHE AAEALGSIAT DDVLPVLKEH LKDSDSVVRE 300
SAIVALDMYE YENSNDLEYA PV 322
Length:322
Mass (Da):36,359
Last modified:August 16, 2004 - v1
Checksum:iF0D713105D85C20D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382122 Genomic DNA. Translation: CAH02551.1.
RefSeqiXP_452158.1. XM_452158.1.

Genome annotation databases

GeneIDi2897036.
KEGGikla:KLLA0B14080g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382122 Genomic DNA. Translation: CAH02551.1 .
RefSeqi XP_452158.1. XM_452158.1.

3D structure databases

ProteinModelPortali Q6CV81.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 28985.Q6CV81.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2897036.
KEGGi kla:KLLA0B14080g.

Phylogenomic databases

eggNOGi COG1413.
HOGENOMi HOG000248665.
KOi K06072.
OMAi RESCQVA.
OrthoDBi EOG7QC85Z.

Enzyme and pathway databases

UniPathwayi UPA00354 .

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
HAMAPi MF_03101. Deoxyhypusine_hydroxylase.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR027517. Deoxyhypusine_hydroxylase.
IPR021133. HEAT_type_2.
IPR004155. PBS_lyase_HEAT.
[Graphical view ]
SMARTi SM00567. EZ_HEAT. 5 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
PROSITEi PS50077. HEAT_REPEAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiDOHH_KLULA
AccessioniPrimary (citable) accession number: Q6CV81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: August 16, 2004
Last modified: September 3, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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