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Q6CV81

- DOHH_KLULA

UniProt

Q6CV81 - DOHH_KLULA

Protein

Deoxyhypusine hydroxylase

Gene

LIA1

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.UniRule annotation

    Catalytic activityi

    [eIF5A]-deoxyhypusine + AH2 + O2 = [eIF5A]-hypusine + A + H2O.UniRule annotation

    Cofactori

    Binds 2 Fe2+ ions per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi78 – 781Iron 1UniRule annotation
    Metal bindingi79 – 791Iron 1UniRule annotation
    Metal bindingi111 – 1111Iron 1UniRule annotation
    Metal bindingi112 – 1121Iron 1UniRule annotation
    Metal bindingi236 – 2361Iron 2UniRule annotation
    Metal bindingi237 – 2371Iron 2UniRule annotation
    Metal bindingi269 – 2691Iron 2UniRule annotation
    Metal bindingi270 – 2701Iron 2UniRule annotation

    GO - Molecular functioni

    1. deoxyhypusine monooxygenase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. peptidyl-lysine modification to peptidyl-hypusine Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Hypusine biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00354.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyhypusine hydroxylaseUniRule annotation (EC:1.14.99.29UniRule annotation)
    Short name:
    DOHHUniRule annotation
    Alternative name(s):
    Deoxyhypusine dioxygenaseUniRule annotation
    Deoxyhypusine monooxygenaseUniRule annotation
    Gene namesi
    Name:LIA1UniRule annotation
    Ordered Locus Names:KLLA0B14080g
    OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
    Taxonomic identifieri284590 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
    ProteomesiUP000000598: Chromosome B

    Subcellular locationi

    Cytoplasm UniRule annotation. Nucleus UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 322322Deoxyhypusine hydroxylasePRO_0000283667Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi28985.Q6CV81.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6CV81.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati76 – 10227HEAT-like PBS-type 1Add
    BLAST
    Repeati109 – 13527HEAT-like PBS-type 2Add
    BLAST
    Repeati267 – 29327HEAT-like PBS-type 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the deoxyhypusine hydroxylase family.UniRule annotation
    Contains 3 HEAT-like PBS-type repeats.UniRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG1413.
    HOGENOMiHOG000248665.
    KOiK06072.
    OMAiRESCQVA.
    OrthoDBiEOG7QC85Z.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    HAMAPiMF_03101. Deoxyhypusine_hydroxylase.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR027517. Deoxyhypusine_hydroxylase.
    IPR021133. HEAT_type_2.
    IPR004155. PBS_lyase_HEAT.
    [Graphical view]
    SMARTiSM00567. EZ_HEAT. 5 hits.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    PROSITEiPS50077. HEAT_REPEAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6CV81-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTNFEKHFE VDVDNCSLEQ LRDILVNNSG KAPLANRFRA LFNLKGHAEE    50
    FASKPEDALK ATQYLAEAFG DESELLKHEV AYVLGQTKNM AGAPLLRDVL 100
    ADDKQQCMVR HEAAEALGAL NDVDSLDILE KYFKEDPLLE IRQTCELAID 150
    RIKWETSEEG RREALQESLY SSIDPAPPFS LEKDYKIQEL KDILNDQNRP 200
    LFERYRAMFR LRDIGNDEAC LALASGFDDP SALFKHEIAY VFGQICNPVV 250
    VPHLKEVLAR PEEAPMVRHE AAEALGSIAT DDVLPVLKEH LKDSDSVVRE 300
    SAIVALDMYE YENSNDLEYA PV 322
    Length:322
    Mass (Da):36,359
    Last modified:August 16, 2004 - v1
    Checksum:iF0D713105D85C20D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382122 Genomic DNA. Translation: CAH02551.1.
    RefSeqiXP_452158.1. XM_452158.1.

    Genome annotation databases

    GeneIDi2897036.
    KEGGikla:KLLA0B14080g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382122 Genomic DNA. Translation: CAH02551.1 .
    RefSeqi XP_452158.1. XM_452158.1.

    3D structure databases

    ProteinModelPortali Q6CV81.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 28985.Q6CV81.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2897036.
    KEGGi kla:KLLA0B14080g.

    Phylogenomic databases

    eggNOGi COG1413.
    HOGENOMi HOG000248665.
    KOi K06072.
    OMAi RESCQVA.
    OrthoDBi EOG7QC85Z.

    Enzyme and pathway databases

    UniPathwayi UPA00354 .

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    HAMAPi MF_03101. Deoxyhypusine_hydroxylase.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR027517. Deoxyhypusine_hydroxylase.
    IPR021133. HEAT_type_2.
    IPR004155. PBS_lyase_HEAT.
    [Graphical view ]
    SMARTi SM00567. EZ_HEAT. 5 hits.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    PROSITEi PS50077. HEAT_REPEAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiDOHH_KLULA
    AccessioniPrimary (citable) accession number: Q6CV81
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3