Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glucokinase-1

Gene

GLK1

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Glukokinase specific for aldohexoses. Phosphorylates glucose and mannose, but not fructose.1 Publication

Catalytic activityi

ATP + D-glucose = ADP + D-glucose 6-phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei101ATPSequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi466 – 471ATPSequence analysis6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glucokinase-1 (EC:2.7.1.2)
Alternative name(s):
Glucose kinase 1
Short name:
GLK-1
Gene namesi
Name:GLK1
Ordered Locus Names:KLLA0C01155g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
Proteomesi
  • UP000000598 Componenti: Chromosome C

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003640881 – 481Glucokinase-1Add BLAST481

Interactioni

Protein-protein interaction databases

STRINGi284590.XP_452246.1.

Structurei

3D structure databases

ProteinModelPortaliQ6CUZ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 477HexokinasePROSITE-ProRule annotationAdd BLAST474

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni64 – 204Hexokinase small subdomainPROSITE-ProRule annotationAdd BLAST141
Regioni146 – 172Glucose-bindingSequence analysisAdd BLAST27
Regioni205 – 466Hexokinase large subdomainPROSITE-ProRule annotationAdd BLAST262

Sequence similaritiesi

Belongs to the hexokinase family.PROSITE-ProRule annotationCurated
Contains 1 hexokinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1369. Eukaryota.
COG5026. LUCA.
HOGENOMiHOG000162670.
InParanoidiQ6CUZ3.
KOiK00844.
OMAiVIINTEC.
OrthoDBiEOG092C2JW4.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PROSITEiPS00378. HEXOKINASE_1. 1 hit.
PS51748. HEXOKINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6CUZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDPKLTKAV DSICDQFIVT KSKISQLTEY FIDCMEKGLE PCESDISQNK
60 70 80 90 100
GLPMIPTFVT DKPSGQEHGV TMLAADLGGT NFRVCSVELL GNHEFKIEQE
110 120 130 140 150
KSKIPTFFFQ DDHHVTSKDL FQHMALITHQ FLTKHHKDVI QDYKWKMGFT
160 170 180 190 200
FSYPVDQTSL SSGKLIRWTK GFKIGDTVGQ DVVQLFQQEL NDIGLSNVHV
210 220 230 240 250
VALTNDTTGT LLARCYASSD AARAINEPVI GCIFGTGTNG CYMEKLENIH
260 270 280 290 300
KLDPASREEL LSQGKTHMCI NTEWGSFDNE LNHLPTTSYD IKIDQQFSTN
310 320 330 340 350
PGFHLFEKRV SGLYLGEILR NILLDLEKQE LFDLKESVLK NNPFILTTET
360 370 380 390 400
LSHIEIDTVE NDLQDTRDAL LKAADLETTF EERVLIQKLV RAISRRAAFL
410 420 430 440 450
AAVPIAAILI KTNALNQSYH CQVEVGCDGS VVEHYPGFRS MMRHALALSP
460 470 480
IGPEGERDVH LRISKDGSGV GAALCALHAN Y
Length:481
Mass (Da):53,757
Last modified:August 16, 2004 - v1
Checksum:i3894D9AA9FD5BEF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382123 Genomic DNA. Translation: CAH01097.1.
RefSeqiXP_452246.1. XM_452246.1.

Genome annotation databases

EnsemblFungiiCAH01097; CAH01097; KLLA0_C01155g.
GeneIDi2892353.
KEGGikla:KLLA0C01155g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382123 Genomic DNA. Translation: CAH01097.1.
RefSeqiXP_452246.1. XM_452246.1.

3D structure databases

ProteinModelPortaliQ6CUZ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi284590.XP_452246.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAH01097; CAH01097; KLLA0_C01155g.
GeneIDi2892353.
KEGGikla:KLLA0C01155g.

Phylogenomic databases

eggNOGiKOG1369. Eukaryota.
COG5026. LUCA.
HOGENOMiHOG000162670.
InParanoidiQ6CUZ3.
KOiK00844.
OMAiVIINTEC.
OrthoDBiEOG092C2JW4.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PROSITEiPS00378. HEXOKINASE_1. 1 hit.
PS51748. HEXOKINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHXKG_KLULA
AccessioniPrimary (citable) accession number: Q6CUZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: August 16, 2004
Last modified: September 7, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.