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Protein

Glucokinase-1

Gene

GLK1

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Glukokinase specific for aldohexoses. Phosphorylates glucose and mannose, but not fructose.1 Publication

Catalytic activityi

ATP + D-glucose = ADP + D-glucose 6-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei101 – 1011ATPSequence Analysis

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi466 – 4716ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glucokinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glucokinase-1 (EC:2.7.1.2)
Alternative name(s):
Glucose kinase 1
Short name:
GLK-1
Gene namesi
Name:GLK1
Ordered Locus Names:KLLA0C01155g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
ProteomesiUP000000598: Chromosome C

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 481481Glucokinase-1PRO_0000364088Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi28985.Q6CUZ3.

Structurei

3D structure databases

ProteinModelPortaliQ6CUZ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 217212Hexokinase type-1Add
BLAST
Domaini228 – 479252Hexokinase type-2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni146 – 17227Glucose-bindingSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the hexokinase family.Curated
Contains 1 hexokinase type-1 domain.Curated
Contains 1 hexokinase type-2 domain.Curated

Phylogenomic databases

eggNOGiCOG5026.
HOGENOMiHOG000162670.
InParanoidiQ6CUZ3.
KOiK00844.
OMAiLENHETE.
OrthoDBiEOG79SF68.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6CUZ3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDPKLTKAV DSICDQFIVT KSKISQLTEY FIDCMEKGLE PCESDISQNK
60 70 80 90 100
GLPMIPTFVT DKPSGQEHGV TMLAADLGGT NFRVCSVELL GNHEFKIEQE
110 120 130 140 150
KSKIPTFFFQ DDHHVTSKDL FQHMALITHQ FLTKHHKDVI QDYKWKMGFT
160 170 180 190 200
FSYPVDQTSL SSGKLIRWTK GFKIGDTVGQ DVVQLFQQEL NDIGLSNVHV
210 220 230 240 250
VALTNDTTGT LLARCYASSD AARAINEPVI GCIFGTGTNG CYMEKLENIH
260 270 280 290 300
KLDPASREEL LSQGKTHMCI NTEWGSFDNE LNHLPTTSYD IKIDQQFSTN
310 320 330 340 350
PGFHLFEKRV SGLYLGEILR NILLDLEKQE LFDLKESVLK NNPFILTTET
360 370 380 390 400
LSHIEIDTVE NDLQDTRDAL LKAADLETTF EERVLIQKLV RAISRRAAFL
410 420 430 440 450
AAVPIAAILI KTNALNQSYH CQVEVGCDGS VVEHYPGFRS MMRHALALSP
460 470 480
IGPEGERDVH LRISKDGSGV GAALCALHAN Y
Length:481
Mass (Da):53,757
Last modified:August 16, 2004 - v1
Checksum:i3894D9AA9FD5BEF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382123 Genomic DNA. Translation: CAH01097.1.
RefSeqiXP_452246.1. XM_452246.1.

Genome annotation databases

GeneIDi2892353.
KEGGikla:KLLA0C01155g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382123 Genomic DNA. Translation: CAH01097.1.
RefSeqiXP_452246.1. XM_452246.1.

3D structure databases

ProteinModelPortaliQ6CUZ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi28985.Q6CUZ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2892353.
KEGGikla:KLLA0C01155g.

Phylogenomic databases

eggNOGiCOG5026.
HOGENOMiHOG000162670.
InParanoidiQ6CUZ3.
KOiK00844.
OMAiLENHETE.
OrthoDBiEOG79SF68.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome evolution in yeasts."
    Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
    , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
    Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37.
  2. "Identification and characterization of a novel glucose-phosphorylating enzyme in Kluyveromyces lactis."
    Kettner K., Mueller E.-C., Otto A., Roedel G., Breunig K.D., Kriegel T.M.
    FEMS Yeast Res. 7:683-692(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiHXKG_KLULA
AccessioniPrimary (citable) accession number: Q6CUZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: August 16, 2004
Last modified: January 7, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.