Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q6CUZ3 (HXKG_KLULA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucokinase-1

EC=2.7.1.2
Alternative name(s):
Glucose kinase 1
Short name=GLK-1
Gene names
Name:GLK1
Ordered Locus Names:KLLA0C01155g
OrganismKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]
Taxonomic identifier284590 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces

Protein attributes

Sequence length481 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Glukokinase specific for aldohexoses. Phosphorylates glucose and mannose, but not fructose. Ref.2

Catalytic activity

ATP + D-glucose = ADP + D-glucose 6-phosphate.

Sequence similarities

Belongs to the hexokinase family.

Contains 1 hexokinase type-1 domain.

Contains 1 hexokinase type-2 domain.

Ontologies

Keywords
   Biological processGlycolysis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glucokinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 481481Glucokinase-1
PRO_0000364088

Regions

Domain6 – 217212Hexokinase type-1
Domain228 – 479252Hexokinase type-2
Nucleotide binding466 – 4716ATP Potential
Region146 – 17227Glucose-binding Potential

Sites

Binding site1011ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q6CUZ3 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 3894D9AA9FD5BEF5

FASTA48153,757
        10         20         30         40         50         60 
MSDPKLTKAV DSICDQFIVT KSKISQLTEY FIDCMEKGLE PCESDISQNK GLPMIPTFVT 

        70         80         90        100        110        120 
DKPSGQEHGV TMLAADLGGT NFRVCSVELL GNHEFKIEQE KSKIPTFFFQ DDHHVTSKDL 

       130        140        150        160        170        180 
FQHMALITHQ FLTKHHKDVI QDYKWKMGFT FSYPVDQTSL SSGKLIRWTK GFKIGDTVGQ 

       190        200        210        220        230        240 
DVVQLFQQEL NDIGLSNVHV VALTNDTTGT LLARCYASSD AARAINEPVI GCIFGTGTNG 

       250        260        270        280        290        300 
CYMEKLENIH KLDPASREEL LSQGKTHMCI NTEWGSFDNE LNHLPTTSYD IKIDQQFSTN 

       310        320        330        340        350        360 
PGFHLFEKRV SGLYLGEILR NILLDLEKQE LFDLKESVLK NNPFILTTET LSHIEIDTVE 

       370        380        390        400        410        420 
NDLQDTRDAL LKAADLETTF EERVLIQKLV RAISRRAAFL AAVPIAAILI KTNALNQSYH 

       430        440        450        460        470        480 
CQVEVGCDGS VVEHYPGFRS MMRHALALSP IGPEGERDVH LRISKDGSGV GAALCALHAN 


Y 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382123 Genomic DNA. Translation: CAH01097.1.
RefSeqXP_452246.1. XM_452246.1.

3D structure databases

ProteinModelPortalQ6CUZ3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING28985.Q6CUZ3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2892353.
KEGGkla:KLLA0C01155g.

Phylogenomic databases

eggNOGCOG5026.
HOGENOMHOG000162670.
KOK00844.
OMAQIMDELG.
OrthoDBEOG79SF68.

Family and domain databases

InterProIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERPTHR19443. PTHR19443. 1 hit.
PfamPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSPR00475. HEXOKINASE.
PROSITEPS00378. HEXOKINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHXKG_KLULA
AccessionPrimary (citable) accession number: Q6CUZ3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: August 16, 2004
Last modified: April 16, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families