Reviewed, UniProtKB/Swiss-Prot Q6CUI0 (NNT1_KLULA)

Names and origin

Protein names

Recommended name:
    Putative nicotinamide N-methyltransferase
    EC=2.1.1.1

Gene names

Name:	NNT1
Ordered Locus Names:	KLLA0C04708g

Organism

Kluyveromyces lactis (Yeast) (Candida sphaerica) [Complete proteome]

Taxonomic identifier

28985 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces

Protein attributes

Sequence length	270 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Putative nicotinamide N-methyltransferase involved in rDNA silencing and in lifespan determination By similarity.
Catalytic activity	S-adenosyl-L-methionine + nicotinamide = S-adenosyl-L-homocysteine + 1-methylnicotinamide.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NNT1 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nicotinamide N-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 270	270	Putative nicotinamide N-methyltransferase		PRO_0000096897

Sequences

	Sequence		Length	Mass (Da)
	Q6CUI0-1 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 6552891554C89FA5	FASTA	270	30,879
	10 20 30 40 50 60 MSDIESLNGG DLFAEPSDFY KPPPEPHFAT YTRDDVPESS TSQQKDIKLR LVGSSPLWGH 70 80 90 100 110 120 LLWNAGIYTA KHMDSHPEEV QDKLVLELGA AGALPTIIAG LLGARKVVST DYPDADLISN 130 140 150 160 170 180 IQYNVDHNIY GGEELFKDEE KRSKQMANRK VVVEGYIWGN DYEPILKHLP QDQQKFDLII 190 200 210 220 230 240 LSDLVFNHTE HAKLFKTTKD LLRENGKALV VFSPHRPWLL ENDLAFFKDC EEFGLKSDLI 250 260 270 ELTHWKPMFD EDEETVEIRS SIYAYYLSHI

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NRRL Y-1140 / WM37.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR382123 Genomic DNA. Translation: CAH01260.1.
RefSeq	XP_452409.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q6CUI0.
Genome annotation databases
GeneID	2892340.
GenomeReviews	Gene locus KLLA0C04708g in contig CR382123_GR.
KEGG	kla:KLLA0C04708g.
Phylogenomic databases
HOGENOM	Q6CUI0.
OMA	VVFSPHR.
Enzyme and pathway databases
BRENDA	2.1.1.1. 74088.
Family and domain databases
InterPro	IPR019410. Methyltransferase-16_put. [Graphical view]
Pfam	PF10294. Methyltransf_16. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NNT1_KLULA

Accession

Primary (citable) accession number: Q6CUI0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	August 16, 2004
Last modified:	November 3, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)