Q6CUI0 (NNT1_KLULA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative nicotinamide N-methyltransferase
EC=2.1.1.1

Gene names

Name:	NNT1
Ordered Locus Names:	KLLA0C04708g

Organism

Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]

Taxonomic identifier

284590 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces

Protein attributes

Sequence length	270 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Putative nicotinamide N-methyltransferase involved in rDNA silencing and in lifespan determination By similarity.
Catalytic activity	S-adenosyl-L-methionine + nicotinamide = S-adenosyl-L-homocysteine + 1-methylnicotinamide.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NNT1 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nicotinamide N-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 270	270	Putative nicotinamide N-methyltransferase		PRO_0000096897

Sequences

	Sequence		Length	Mass (Da)
	Q6CUI0 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 6552891554C89FA5	FASTA	270	30,879
	10 20 30 40 50 60 MSDIESLNGG DLFAEPSDFY KPPPEPHFAT YTRDDVPESS TSQQKDIKLR LVGSSPLWGH 70 80 90 100 110 120 LLWNAGIYTA KHMDSHPEEV QDKLVLELGA AGALPTIIAG LLGARKVVST DYPDADLISN 130 140 150 160 170 180 IQYNVDHNIY GGEELFKDEE KRSKQMANRK VVVEGYIWGN DYEPILKHLP QDQQKFDLII 190 200 210 220 230 240 LSDLVFNHTE HAKLFKTTKD LLRENGKALV VFSPHRPWLL ENDLAFFKDC EEFGLKSDLI 250 260 270 ELTHWKPMFD EDEETVEIRS SIYAYYLSHI

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR382123 Genomic DNA. Translation: CAH01260.1.
RefSeq	XP_452409.1. XM_452409.1.
3D structure databases
ProteinModelPortal	Q6CUI0.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6CUI0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2892340.
GenomeReviews	Gene locus KLLA0C04708g in contig CR382123_GR.
KEGG	kla:KLLA0C04708g.
Phylogenomic databases
eggNOG	fuNOG05731.
HOGENOM	HBG397955.
OMA	HLLWNAG.
OrthoDB	EOG4MKRRQ.
Family and domain databases
InterPro	IPR019410. Nicotinamide_N-MeTfrase_put. [Graphical view]
Pfam	PF10294. Methyltransf_16. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NNT1_KLULA

Accession

Primary (citable) accession number: Q6CUI0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	August 16, 2004
Last modified:	December 14, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program