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Protein

Acyl-CoA desaturase

Gene

KLLA0_C05566g

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Stearyl-CoA desaturase that utilizes O2 and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.UniRule annotation

Catalytic activityi

Stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O.UniRule annotation

Cofactori

Fe2+UniRule annotationNote: Expected to bind 2 Fe2+ ions per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
Biological processElectron transportUniRule annotation, Fatty acid biosynthesisUniRule annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Transport
LigandHemeUniRule annotationSAAS annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA desaturaseUniRule annotation (EC:1.14.19.1UniRule annotation)
Gene namesi
ORF Names:KLLA0_C05566gImported
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)Imported
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
Proteomesi
  • UP000000598 Componenti: Chromosome C

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei80 – 99HelicalSequence analysisAdd BLAST20
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi284590.XP_452447.1.

Structurei

3D structure databases

ProteinModelPortaliQ6CUE2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini379 – 457Cytochrome b5 heme-bindingInterPro annotationAdd BLAST79

Sequence similaritiesi

Belongs to the fatty acid desaturase type 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0537. Eukaryota.
KOG1600. Eukaryota.
COG1398. LUCA.
COG5274. LUCA.
HOGENOMiHOG000270353.
InParanoidiQ6CUE2.
KOiK00507.
OMAiFNGGVYF.
OrthoDBiEOG092C2CE8.

Family and domain databases

CDDicd03505. Delta9-FADS-like. 1 hit.
Gene3Di3.10.120.10. 1 hit.
InterProiView protein in InterPro
IPR009160. Acyl-CoA_deSatase_haem/ster-bd.
IPR015876. Acyl-CoA_DS.
IPR001199. Cyt_B5-like_heme/steroid-bd.
IPR018506. Cyt_B5_heme-BS.
IPR005804. FA_desaturase_dom.
IPR001522. FADS-1_CS.
PANTHERiPTHR11351. PTHR11351. 1 hit.
PfamiView protein in Pfam
PF00173. Cyt-b5. 1 hit.
PF00487. FA_desaturase. 1 hit.
PIRSFiPIRSF000345. OLE1. 1 hit.
PRINTSiPR00075. FACDDSATRASE.
SMARTiView protein in SMART
SM01117. Cyt-b5. 1 hit.
SUPFAMiSSF55856. SSF55856. 1 hit.
PROSITEiView protein in PROSITE
PS00191. CYTOCHROME_B5_1. 1 hit.
PS50255. CYTOCHROME_B5_2. 1 hit.
PS00476. FATTY_ACID_DESATUR_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6CUE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQVDLVNAN VLAAGANKKS VRVVNGLGSL MGSKQMADVD FENDSNMDYL
60 70 80 90 100
LEQDKKEKEK YKNKRHISEL PWTLNNWHLH LNWLNLILVV AIPLYGVYMA
110 120 130 140 150
LSGRVPLRHE ILIFSMIYYC IGGISITGGY HRLWAHRAYS AHWPLRLFFA
160 170 180 190 200
VFGAASVEGS IKWWSHSHRI HHRYTDTVRD PYDARRGLWY SHMGWMLLQP
210 220 230 240 250
NPKHRARADI ADLTDDWIVR WQHRNYIPLM LFSAFILPAL FCHYMWNDFW
260 270 280 290 300
GGLIYGGVLR VCAIQQATFC INSLAHYLGD QPFDDRRTPR DNWITALVTF
310 320 330 340 350
GEGYHNFHHE FPTDYRNAIK WYQYDPTKVL IYLTSLFGLS YDLKKFSQNA
360 370 380 390 400
IQQGLVQQQQ KKLDRTRSKL NWGSPLSKLP VWDKDEFMEK LKSNNGLVVI
410 420 430 440 450
SGIVHDVSGY ITEHPGGETL IQASLGKDAT KAFNGGVYLH SNAAHNILAT
460 470
MRIAVVKDNV DQAAKFAARR GEVYEKK
Length:477
Mass (Da):55,001
Last modified:August 16, 2004 - v1
Checksum:i4ED05C42279A2384
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382123 Genomic DNA. Translation: CAH01298.1.
RefSeqiXP_452447.1. XM_452447.1.

Genome annotation databases

EnsemblFungiiCAH01298; CAH01298; KLLA0_C05566g.
GeneIDi2892035.
KEGGikla:KLLA0C05566g.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ6CUE2_KLULA
AccessioniPrimary (citable) accession number: Q6CUE2
Entry historyiIntegrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: June 7, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported