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Q6CU71 (GUAA_KLULA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GMP synthase [glutamine-hydrolyzing]
EC=6.3.5.2
Alternative name(s):
GMP synthetase
Glutamine amidotransferase
Gene names
Name:GUA1
Ordered Locus Names:KLLA0C07172g
OrganismKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]
Taxonomic identifier284590 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces

Protein attributes

Sequence length524 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate.

Pathway

Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Contains 1 glutamine amidotransferase type-1 domain.

Contains 1 GMPS ATP-PPase (ATP pyrophosphatase) domain.

Ontologies

Keywords
   Biological processGMP biosynthesis
Purine biosynthesis
   Cellular componentCytoplasm
   DomainGlutamine amidotransferase
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processGMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

glutamine metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

GMP synthase (glutamine-hydrolyzing) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 524524GMP synthase [glutamine-hydrolyzing]
PRO_0000286151

Regions

Domain12 – 201190Glutamine amidotransferase type-1
Domain202 – 399198GMPS ATP-PPase
Nucleotide binding230 – 2367ATP By similarity

Sites

Active site881For GATase activity By similarity
Active site1751For GATase activity By similarity
Active site1771For GATase activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6CU71 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 0E7C87D904FE3FE5

FASTA52458,555
        10         20         30         40         50         60 
MSPVEVSNVF DTILVLDFGS QYSHLITRRL REFNVYAEML PCTQKIADLH WKPKGVILSG 

        70         80         90        100        110        120 
GPYSVYEKDA PHVDKAIFDL GVPILGICYG LQEIAWINNT EVGRGEKREY GPATLRVEDK 

       130        140        150        160        170        180 
SCPLFANVDH STVWMSHHDK VHNLPAGFKI TATSENSPFC GIANEDKQIY GIQFHPEVTH 

       190        200        210        220        230        240 
STQGKTLLRN FAVDICKASQ SWNMENFIDT EINRIRELVG PDAEVIGAVS GGVDSTVAAK 

       250        260        270        280        290        300 
LMDRAIGDRF HAIMVDNGVL RLNEAATVKK TLGEGLGINL TVVDASDEFL DKLKGVTDPE 

       310        320        330        340        350        360 
KKRKIIGNTF IHVFEREAAK IQPKNGKEIE FLLQGTLYPD VIESISFKGP SQTIKTHHNV 

       370        380        390        400        410        420 
GGLLENMKLK LIEPLRELFK DEVRELGELL GISHELVWRH PFPGPGIAIR VLGEVTREQV 

       430        440        450        460        470        480 
AIARKADYIY IEEIRKAGLY NNISQAFACL LPVKSVGVMG DQRTYEQVIA LRAIETTDFM 

       490        500        510        520 
TADWYPFEHS FLKKVASRIV NEVDGVARVT YDITSKPPAT VEWE

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR382123 Genomic DNA. Translation: CAH01369.1.
RefSeqXP_452518.1. XM_452518.1.

3D structure databases

HSSPHSSP built from PDB template 1GPM based on UniProtKB P04079.
ProteinModelPortalQ6CU71.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ6CU71.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2892690.
GenomeReviewsGene locus KLLA0C07172g in contig CR382123_GR.
KEGGkla:KLLA0C07172g.

Phylogenomic databases

eggNOGfuNOG07551.
HOGENOMHBG391775.
OMADGRTYEY.
OrthoDBEOG4WWVST.

Family and domain databases

InterProIPR017926. GATASE_1.
IPR001674. GMP_synth_C.
IPR004739. GMP_synth_N.
IPR022955. GMP_synthase.
IPR022310. NAD/GMP_synthase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
Gene3DG3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KOK01951.
PfamPF00117. GATase. 1 hit.
PF00958. GMP_synt_C. 1 hit.
PF02540. NAD_synthase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00884. GuaA_Cterm. 1 hit.
TIGR00888. GuaA_Nterm. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
PS51553. GMPS_ATP_PPASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGUAA_KLULA
AccessionPrimary (citable) accession number: Q6CU71
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: August 16, 2004
Last modified: January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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