Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q6CTX8 (PYRD2_KLULA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Short name=DHOD
Short name=DHODase
Short name=DHOdehase
EC=1.3.5.2
Alternative name(s):
Dihydroorotate oxidase
Gene names
Name:URA9
Ordered Locus Names:KLLA0C09240g
OrganismKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]
Taxonomic identifier284590 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces

Protein attributes

Sequence length445 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor By similarity.

Catalytic activity

(S)-dihydroorotate + a quinone = orotate + a quinol.

Cofactor

Binds 1 FMN per subunit By similarity.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.

Subcellular location

Mitochondrion inner membrane By similarity; Single-pass membrane protein Potential.

Miscellaneous

K.lactis has two isoforms of DHODase, a cytoplasmic isoform and a mitochondrial isoform.

Sequence similarities

Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 1616Mitochondrion Potential
Chain17 – 445429Dihydroorotate dehydrogenase (quinone), mitochondrial
PRO_0000029893

Regions

Transmembrane39 – 5618Helical; Potential
Nucleotide binding124 – 1285FMN By similarity
Nucleotide binding407 – 4082FMN By similarity
Region173 – 1775Substrate binding By similarity
Region251 – 2566Substrate binding By similarity
Region331 – 3322Substrate binding By similarity

Sites

Active site2541Nucleophile By similarity
Binding site1281Substrate By similarity
Binding site1481FMN By similarity
Binding site2211FMN By similarity
Binding site2511FMN By similarity
Binding site3021FMN By similarity
Binding site3301FMN; via carbonyl oxygen By similarity
Binding site3561FMN; via amide nitrogen By similarity
Binding site3861FMN; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6CTX8 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 74F746F6773A3492

FASTA44548,071
        10         20         30         40         50         60 
MNSGFPRILS KKLFTLNQSQ FFVKNGMVPL KAGISGPKLL KYTVGIAIGS FAGFYFSNSR 

        70         80         90        100        110        120 
SAFHEYVLCP MLRLVTPDAE DGHKLGIWFL KNGLAPRLWF DNDDKVLNVN IFGKKLTNPI 

       130        140        150        160        170        180 
GCAAGLDKNG DAIDGILSGG FGYIEIGSVT PLPQPGNPRP RFFRLPLDDA VINRYGFNSS 

       190        200        210        220        230        240 
GHDTVVNTLQ SRITSFINSY MFKDNSVENL SLYKDKLLGV NLGKNKTGDE VQDYLKGVES 

       250        260        270        280        290        300 
FQKYADVLVI NVSSPNTPGL RSLQKESILT DLLTQVVAKR DSLVTSGNAL GAKTHKPPVL 

       310        320        330        340        350        360 
VKVAPDLVEE EIKSIAEAAK KSKVDGIIIS NTTIQRPTTL ITEDSDLVSQ AGGLSGKPLK 

       370        380        390        400        410        420 
PLALKALKTM AKYTKGSGLV LVGCGGISSG ADAIEFAKAG ASMVELYTAY AYKGPGLIAK 

       430        440 
IKDETTELLK KENKTWSEII GEDIK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR382123 Genomic DNA. Translation: CAH01462.1.
RefSeqXP_452611.1. XM_452611.1.

3D structure databases

ProteinModelPortalQ6CTX8.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ6CTX8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2891871.
GenomeReviewsGene locus KLLA0C09240g in contig CR382123_GR.
KEGGkla:KLLA0C09240g.

Phylogenomic databases

eggNOGfuNOG05791.
HOGENOMHBG351027.
OMAAALNRMG.
OrthoDBEOG4NS6M1.

Family and domain databases

InterProIPR013785. Aldolase_TIM.
IPR012135. Dihydroorotate_DH_1_2.
IPR005719. Dihydroorotate_DH_2.
IPR001295. Dihydroorotate_DH_CS.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK00226.
PfamPF01180. DHO_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR01036. PyrD_sub2. 1 hit.
PROSITEPS00911. DHODEHASE_1. 1 hit.
PS00912. DHODEHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRD2_KLULA
AccessionPrimary (citable) accession number: Q6CTX8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: August 16, 2004
Last modified: December 14, 2011
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents