Reviewed,
UniProtKB/Swiss-Prot Q6CTX8 (PYRD2_KLULA)
Last modified
February 9, 2010.
Version 53.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Dihydroorotate dehydrogenase, mitochondrial Short name=DHOdehase Short name=DHODase Short name=DHOD EC=1.3.5.2 Alternative name(s): Dihydroorotate oxidase | ||||
| Gene names |
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| Organism | Kluyveromyces lactis (Yeast) (Candida sphaerica) [Complete proteome] | ||||
| Taxonomic identifier | 28985 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces |
Protein attributes
| Sequence length | 445 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | (S)-dihydroorotate + a quinone = orotate + a quinol. |
| Cofactor | Binds 1 FMN per subunit By similarity. |
| Pathway | |
| Subcellular location | Mitochondrion inner membrane By similarity; Single-pass membrane protein Potential. |
| Miscellaneous | K.lactis has two isoforms of DHODase, a cytoplasmic isoform and a mitochondrial isoform. |
| Sequence similarities | Belongs to the dihydroorotate dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Pyrimidine biosynthesis |
| Cellular component | Membrane Mitochondrion Mitochondrion inner membrane |
| Domain | Transit peptide Transmembrane |
| Ligand | FMN Flavoprotein |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | 'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro UMP biosynthetic processInferred from electronic annotation. Source: InterPro oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial inner membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | dihydroorotate oxidase activity Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. Souciet J.-L.Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NRRL Y-1140 / WM37. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CR382123 Genomic DNA. Translation: CAH01462.1. |
| RefSeq | XP_452611.1. |
3D structure databases | |
| SMR | Q6CTX8. Positions 62-445. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q6CTX8. |
Genome annotation databases | |
| GeneID | 2891871. |
| GenomeReviews | Gene locus KLLA0C09240g in contig CR382123_GR. |
| KEGG | kla:KLLA0C09240g. |
Phylogenomic databases | |
| eggNOG | fuNOG05791. |
| HOGENOM | HBG351027. |
| OMA | AALNRMG. |
| OrthoDB | EOG9CNS7M. |
| PhylomeDB | Q6CTX8. |
Enzyme and pathway databases | |
| BRENDA | 1.3.3.1. 74088. |
Family and domain databases | |
| InterPro | IPR013785. Aldolase_TIM. IPR012135. Dihydroorotate_DH_1_2. IPR005719. Dihydroorotate_DH_2. IPR001295. Dihydroorotate_DH_CS. [Graphical view] |
| Gene3D | G3DSA:3.20.20.70. Aldolase_TIM. 1 hit. |
| Pfam | PF01180. DHO_dh. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01036. pyrD_sub2. 1 hit. |
| PROSITE | PS00911. DHODEHASE_1. 1 hit. PS00912. DHODEHASE_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PYRD2_KLULA | ||||||||
| Accession | Primary (citable) accession number: Q6CTX8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


