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Protein

Glutamate decarboxylase

Gene

KLLA0C14432g

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Ordered Locus Names:KLLA0C14432gImported
ORF Names:KLLA0_C14432gImported
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)Imported
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
ProteomesiUP000000598 Componenti: Chromosome C

Interactioni

Protein-protein interaction databases

STRINGi28985.Q6CT93.

Structurei

3D structure databases

ProteinModelPortaliQ6CT93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000070228.
InParanoidiQ6CT93.
KOiK01580.
OMAiNIRTEND.
OrthoDBiEOG7P2Z22.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 2 hits.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6CT93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHKEKDIEE SKRFFHHSTS GMEGNPDGFG LLPDGSKLES VKDTRIDKFA
60 70 80 90 100
VPKKGLHSEH VYNLVKNELK LDGNPVLNLA SFVNTFTDQF AQKLIDENLN
110 120 130 140 150
KNLADNDEYP QLIHMNERCI SMLAKLWQSD TDRDTPLGCA TTGSSEAIML
160 170 180 190 200
GGLAMKRQWE KKMRAANKST EKPNIIMSSA CQVALEKFAR YFDVECRLVP
210 220 230 240 250
VDTEHGYHLN PNKLWDYVNE NTIGIFVILG TTYTGHLENI EQVAEVLEHI
260 270 280 290 300
EAQHPDWSNK DIPIHVDGAS GGFIVPFAFT EAQMESYGLG RWGFNHPRVV
310 320 330 340 350
SINTSGHKFG LTTPGLGWIV WKNDEYLLPE LRFKLKYLGG IEETFNLNFS
360 370 380 390 400
RPGFQVIHQY YNLLTLGQQG YYEKFNQSIF VARAFAWKLL QDPDMRDVFE
410 420 430 440 450
VVSCLHENLD NSSIAESLDD YWKNPHDYKP GIPLCAFKLS EKFKSEHPEI
460 470 480 490 500
PQSIISTLLR QKGWIIPNYP LPESTDGSDK KEVLRVVFRI EMKLDMALLL
510 520 530 540 550
VQDVFEVVQK LLKSYEYLNI RTENDNHAVF KVLSTLSNAD VSELEHELTD
560
SQKEKEQHIK KNYRGTC
Length:567
Mass (Da):64,941
Last modified:August 15, 2004 - v1
Checksum:i51AAC074CB3AE3E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382123 Genomic DNA. Translation: CAH01697.1.
RefSeqiXP_452846.1. XM_452846.1.

Genome annotation databases

GeneIDi2892276.
KEGGikla:KLLA0C14432g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382123 Genomic DNA. Translation: CAH01697.1.
RefSeqiXP_452846.1. XM_452846.1.

3D structure databases

ProteinModelPortaliQ6CT93.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi28985.Q6CT93.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2892276.
KEGGikla:KLLA0C14432g.

Phylogenomic databases

HOGENOMiHOG000070228.
InParanoidiQ6CT93.
KOiK01580.
OMAiNIRTEND.
OrthoDBiEOG7P2Z22.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 2 hits.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome evolution in yeasts."
    Genolevures
    Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
    , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
    Nature 430:35-44(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37Imported.

Entry informationi

Entry nameiQ6CT93_KLULA
AccessioniPrimary (citable) accession number: Q6CT93
Entry historyi
Integrated into UniProtKB/TrEMBL: August 15, 2004
Last sequence update: August 15, 2004
Last modified: February 3, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.