Q6CT57 (RIFK_KLULA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Riboflavin kinase
EC=2.7.1.26

Alternative name(s):
Flavin mononucleotide kinase 1

Gene names

Name:	FMN1
Ordered Locus Names:	KLLA0C15213g

Organism

Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]

Taxonomic identifier

284590 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces › Kluyveromyces lactis

Protein attributes

Sequence length	185 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme By similarity.
Catalytic activity	ATP + riboflavin = ADP + FMN.
Cofactor	Zinc or magnesium By similarity.
Pathway	Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.
Sequence similarities	Belongs to the flavokinase family.

Ontologies

Keywords
Ligand	ATP-binding FMN Magnesium Metal-binding Nucleotide-binding Zinc
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	FMN biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway riboflavin biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW riboflavin kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 185	185	Riboflavin kinase		PRO_0000301842
Sites
	Active site	122	1	Nucleophile By similarity
	Metal binding	41	1	Magnesium or zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6CT57 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 6ECE5B40481696DA	FASTA	185	20,939
	10 20 30 40 50 60 MTRHCDVSIP DSPEPPFPIT TSFVDVIAGF GRGSAELGIP TANVPIDDLP KIVEQLDTGV 70 80 90 100 110 120 YFGWCKVRMA KDRDTKVEQR PDGREVQYNN GTLLNDEDLA VLPVVLSVGW NPFYQNKNKT 130 140 150 160 170 180 VELHIIHKFS DNFYGAQIKF NFLGYIRPEL DYTTKDALIA DIHTDIEIAK EKLQLPGYRK LKDTL

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR382123 Genomic DNA. Translation: CAH01733.1.
RefSeq	XP_452882.1. XM_452882.1.
3D structure databases
HSSP	HSSP built from PDB template 1N08 based on UniProtKB O74866.
ProteinModelPortal	Q6CT57.
ModBase	Search...
Protein-protein interaction databases
STRING	28985.Q6CT57.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2891986.
KEGG	kla:KLLA0C15213g.
Phylogenomic databases
eggNOG	COG0196.
HOGENOM	HOG000260803.
KO	K00861.
OMA	IRPELDY.
OrthoDB	EOG4BCHXC.
Enzyme and pathway databases
UniPathway	UPA00276; UER00406.
Family and domain databases
Gene3D	2.40.30.30. 1 hit.
InterPro	IPR023468. Riboflavin_kinase. IPR015865. Riboflavin_kinase_bac/euk. IPR023465. Riboflavin_kinase_domain. [Graphical view]
PANTHER	PTHR22749. PTHR22749. 1 hit.
Pfam	PF01687. Flavokinase. 1 hit. [Graphical view]
SMART	SM00904. Flavokinase. 1 hit. [Graphical view]
SUPFAM	SSF82114. Riboflavin_kinase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RIFK_KLULA

Accession

Primary (citable) accession number: Q6CT57

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	August 16, 2004
Last modified:	May 1, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program