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Q6CT57

- RIFK_KLULA

UniProt

Q6CT57 - RIFK_KLULA

Protein

Riboflavin kinase

Gene

FMN1

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.By similarity

    Catalytic activityi

    ATP + riboflavin = ADP + FMN.

    Cofactori

    Zinc or magnesium.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi41 – 411Magnesium or zincBy similarity
    Active sitei122 – 1221NucleophileBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. riboflavin kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. FMN biosynthetic process Source: UniProtKB-UniPathway
    2. riboflavin biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Flavoprotein, FMN, Magnesium, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00276; UER00406.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Riboflavin kinase (EC:2.7.1.26)
    Alternative name(s):
    Flavin mononucleotide kinase 1
    Gene namesi
    Name:FMN1
    Ordered Locus Names:KLLA0C15213g
    OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
    Taxonomic identifieri284590 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
    ProteomesiUP000000598: Chromosome C

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 185185Riboflavin kinasePRO_0000301842Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi28985.Q6CT57.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6CT57.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the flavokinase family.Curated

    Phylogenomic databases

    eggNOGiCOG0196.
    HOGENOMiHOG000260803.
    KOiK00861.
    OMAiLGWNPFY.
    OrthoDBiEOG7K3V05.

    Family and domain databases

    Gene3Di2.40.30.30. 1 hit.
    InterProiIPR023468. Riboflavin_kinase.
    IPR015865. Riboflavin_kinase_bac/euk.
    IPR023465. Riboflavin_kinase_domain.
    [Graphical view]
    PANTHERiPTHR22749. PTHR22749. 1 hit.
    PfamiPF01687. Flavokinase. 1 hit.
    [Graphical view]
    SMARTiSM00904. Flavokinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF82114. SSF82114. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q6CT57-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTRHCDVSIP DSPEPPFPIT TSFVDVIAGF GRGSAELGIP TANVPIDDLP    50
    KIVEQLDTGV YFGWCKVRMA KDRDTKVEQR PDGREVQYNN GTLLNDEDLA 100
    VLPVVLSVGW NPFYQNKNKT VELHIIHKFS DNFYGAQIKF NFLGYIRPEL 150
    DYTTKDALIA DIHTDIEIAK EKLQLPGYRK LKDTL 185
    Length:185
    Mass (Da):20,939
    Last modified:August 16, 2004 - v1
    Checksum:i6ECE5B40481696DA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382123 Genomic DNA. Translation: CAH01733.1.
    RefSeqiXP_452882.1. XM_452882.1.

    Genome annotation databases

    GeneIDi2891986.
    KEGGikla:KLLA0C15213g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382123 Genomic DNA. Translation: CAH01733.1 .
    RefSeqi XP_452882.1. XM_452882.1.

    3D structure databases

    ProteinModelPortali Q6CT57.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 28985.Q6CT57.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2891986.
    KEGGi kla:KLLA0C15213g.

    Phylogenomic databases

    eggNOGi COG0196.
    HOGENOMi HOG000260803.
    KOi K00861.
    OMAi LGWNPFY.
    OrthoDBi EOG7K3V05.

    Enzyme and pathway databases

    UniPathwayi UPA00276 ; UER00406 .

    Family and domain databases

    Gene3Di 2.40.30.30. 1 hit.
    InterProi IPR023468. Riboflavin_kinase.
    IPR015865. Riboflavin_kinase_bac/euk.
    IPR023465. Riboflavin_kinase_domain.
    [Graphical view ]
    PANTHERi PTHR22749. PTHR22749. 1 hit.
    Pfami PF01687. Flavokinase. 1 hit.
    [Graphical view ]
    SMARTi SM00904. Flavokinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF82114. SSF82114. 2 hits.
    ProtoNeti Search...

    Entry informationi

    Entry nameiRIFK_KLULA
    AccessioniPrimary (citable) accession number: Q6CT57
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3