Reviewed, UniProtKB/Swiss-Prot Q6CSX2 (ATG1_KLULA)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein kinase ATG1
    EC=2.7.11.1
Alternative name(s):
    Autophagy-related protein 1

Gene names

Name:	ATG1
Ordered Locus Names:	KLLA0C17160g

Organism

Kluyveromyces lactis (Yeast) (Candida sphaerica) [Complete proteome]

Taxonomic identifier

28985 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces

Protein attributes

Sequence length	831 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Serine/threonine protein kinase probably involved in the cytoplasm to vacuole transport (Cvt) and in autophagy, where it may be required for the formation of autophagosomes By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Autophagy Protein transport Transport
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 831	831	Serine/threonine-protein kinase ATG1		PRO_0000085647
Regions
	Domain	21 – 321	301	Protein kinase
	Nucleotide binding	27 – 35	9	ATP By similarity
Sites
	Active site	168	1	Proton acceptor By similarity
	Binding site	50	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6CSX2-1 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: E9C29F1492D9A489	FASTA	831	94,026
	10 20 30 40 50 60 MSSESHDKVV AKAIRLPTEN YSVEKEIGKG SFAVVYKGLS LRDGRNIAIK AVSRSKLKNK 70 80 90 100 110 120 KLLENLEVEI AILKKIKHPH IVGLIDCERT SSDFYLIMEY CALGDLTFFI KKRKNLVLKH 130 140 150 160 170 180 PLIKTVFEHY PPPSTEHNGL NRVLVVNYLQ QLSSALKFLR SKNLVHRDIK PQNLLLCTPL 190 200 210 220 230 240 LDYNDPKTFH ELGFVGIYNL PILKIADFGF ARFLPNTSLA ETLCGSPLYM APEILNYQKY 250 260 270 280 290 300 NAKADLWSVG TVLYEMCCGR PPFKASNHLE LFQKIKKAND EITVPSNCYI EPKLFNLIRG 310 320 330 340 350 360 LLTFDPDSRM GFTDFFNNEV VTEDLTRYEQ SYEPDLESKS KDVAESNMFV SEYLVKPLKQ 370 380 390 400 410 420 QESAHIPPTQ TDENTSVQTG VRRTSGKERL ATNHPPHQQI HPEDNSQNPE QSYQSASQKR 430 440 450 460 470 480 LKSSYNDLIL EKEYVVVEKK TVEVNSLADD FANNGPITNN QGAQVIKPLR YRTSSSSDAS 490 500 510 520 530 540 GGRRASLVER RLSISSLSPS NALSKALGLA SVRLFGYQHN TKATSSPPQQ TLLNPQIFQE 550 560 570 580 590 600 LTENAVLRAD HKLNPFSEQM LDSNITPAVE SLAAKAFVMY SFAEMKFSQI LPTPPSSTDY 610 620 630 640 650 660 DPLSDKRLSN GSCAIEDEED LDQGRPPSNQ TLTSATTKIS SATNVDTQIP APELKKLCTE 670 680 690 700 710 720 SLLLYLKALT ILAASMKLTS KWWYENESKN CTLKLNILVQ WIRDRFNECL DKAEFLRLKL 730 740 750 760 770 780 HAINTSPNSQ WSDDDPVIFV EKLIYDRALD ISRNAARMEM ESGNYNTCEL AYATSLWMLE 790 800 810 820 830 ILLDENFQFN EVYDDEYASN ITSLDESDKE MIKKYISSIA NRLKALKSKM V

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NRRL Y-1140 / WM37.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR382123 Genomic DNA. Translation: CAH01818.1.
RefSeq	XP_452967.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q6CSX2.
Genome annotation databases
GeneID	2892164.
GenomeReviews	Gene locus KLLA0C17160g in contig CR382123_GR.
KEGG	kla:KLLA0C17160g.
Phylogenomic databases
HOGENOM	Q6CSX2.
OMA	KYNAKAD.
Enzyme and pathway databases
BRENDA	2.7.11.1. 74088.
Family and domain databases
InterPro	IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATG1_KLULA

Accession

Primary (citable) accession number: Q6CSX2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	August 16, 2004
Last modified:	November 3, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)